DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi3K92E and Pik3c2g

DIOPT Version :9

Sequence 1:NP_001262770.1 Gene:Pi3K92E / 42446 FlyBaseID:FBgn0015279 Length:1088 Species:Drosophila melanogaster
Sequence 2:NP_446375.1 Gene:Pik3c2g / 116720 RGDID:620231 Length:1505 Species:Rattus norvegicus


Alignment Length:1186 Identity:295/1186 - (24%)
Similarity:475/1186 - (40%) Gaps:299/1186 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    89 EACEYQV-------YGISTFNIEPYTDETKRLSEVQPYFGILSLGERTDTTSFSSDYELTKMVNG 146
            |.|.|.|       :..|.::::...|..::.|      |...|.|  .:..||.|..|.:....
  Rat   162 EHCNYYVEPENNVPHHYSPYSMDSIPDSEEKGS------GDADLVE--PSLVFSKDSFLPRASEN 218

  Fly   147 MIGTTFDHNRTHGSP-EI----DDFRLYMTQTCDNIELERSAY-----------------TWQQR 189
            |   :.:.....|.| ||    ......:...|:|:...|..|                 .:..|
  Rat   219 M---SVESTEPIGCPLEIVEAPQGSNKSLASFCNNVTKIRGLYHASDTNSNSGKIWAITTAYPSR 280

  Fly   190 LLYEHPLRLANSTKMPELIRERHPTRTFLIVVKNENDQSTFTLSVNEQDTPFSLTESTLQKMNRS 254
            |..:...|:..||.....:....|...:|:   .:.......|..|||.:|              
  Rat   281 LFADTQFRVKISTDNSAQLLLLKPPANYLV---KDLIAEILLLCANEQLSP-------------- 328

  Fly   255 QMKMNDRTSDYILKVSGRDEYL-----LGDYPLIQ-----------------------------F 285
                    .:|:|.:.|.:|:|     ||.:.:.|                             .
  Rat   329 --------KEYLLSICGSEEFLQTDHCLGSHKIFQKSKSVIQLHLQRSRDTPGKLSRKRDDDRSR 385

  Fly   286 LYIQEMLSDSAVPNVVLQSVYRLESYINHHNEQAMVTKRPLPKKRTVHLHKSISSLWDMGNY--- 347
            :::.::|..:.:..:..|.:..:....|.|.|..:.|:..:.:       |.:||::..|.:   
  Rat   386 VHLNQLLEFTHIWKISRQCLSTVMKSYNLHVEHLLKTQEDVEE-------KPLSSMFSCGRHPPQ 443

  Fly   348 -----------------------------FQLTL---------HS---------ISNVNFDKTRA 365
                                         .:|||         |.         |.||..:.:|:
  Rat   444 PHGNDIIEDVRNICSVLGCIETKQVSDAVKELTLILQRPSQNFHQNSETSKKGFIENVTSELSRS 508

  Fly   366 L---------------------------KVGVH------VCLYH--------------------- 376
            |                           ..|:|      ||..|                     
  Rat   509 LHQLVDVYCSSFCTDFRPARAPGGVSRDHAGLHSHLSFTVCSLHNVPETWAHSYKAFSFSCWLTY 573

  Fly   377 GDKKLCAQRSTDS-PNGNFDTFLFN-DLVMDFDIQMRNLPRMTRLCIVIFEVTKMSRSKKSSNNK 439
            ..||||..:|..| |.....:|..| :.:::|.:::::|||.:.|.|.:|.:...:.|       
  Rat   574 AGKKLCQVKSCRSLPVTKSFSFSVNWNEIINFPLEIKSLPRESMLVIKLFGIDSATHS------- 631

  Fly   440 DIALKDVPYNKNPLAWVNTTIFDHKDILRTGRHTLYTWTYADDIQSVEVFHPLG------TIEPN 498
                      .|.|||....:|..:.                        .|||      |::..
  Rat   632 ----------ANLLAWTCLPLFPKEK------------------------SPLGSRLLSMTLQSE 662

  Fly   499 PRKEECA--LVDLTFLSSGTGTVRYPSEEVVLQYAADREQVNRLQRQLAGPEKPIKELKELMANY 561
            |..|..|  :.|.:..:..|..:.:|:  ...:|.....:.||...|     :|.:|..:.:|..
  Rat   663 PPIEMMAPGVWDGSQPTPLTLQIDFPA--ATWEYVKPETEENRTDHQ-----EPPRECLKHIARL 720

  Fly   562 TGLDKIYEMVDQDRNAIWERR---NDILRELPEELSILLHCVYWKERDDVADMWYLLKQWPLISI 623
            :.......:..:.|..:|..|   |:....||   .:|.....|.| ..|::|..:|::|.....
  Rat   721 SQKQPPLLLSVEKRRYLWFYRFYCNNENSSLP---LVLGSAPGWDE-GTVSEMHAVLRRWTFSHP 781

  Fly   624 ERSLELLDYAYPDPAVRRFAIRCL-HFLKDEDLLLYLLQLVQAIKHESYLESDLVVFLLERALRN 687
            ..:|.||...:||..:|..|::.| :||.|| ||..|.|||||:|.|..|||.||..||.|:|::
  Rat   782 LEALGLLTSRFPDQDIREVAVQQLDNFLTDE-LLDCLPQLVQAVKFEWSLESPLVELLLHRSLQS 845

  Fly   688 QRIGHYFFWHLRSEMQTPSMQTRFGLLLEVYLKGCKHH--VAPLRKQLHVL-------EKLKQGS 743
            .|:.|..||.||........::.:..||.. |:.|...  :..|.|:..::       ||:|...
  Rat   846 IRVAHRLFWLLRDAQGEDYFKSWYQELLAA-LQFCAGEALIEELSKEQKLVKLLGDIGEKVKSAG 909

  Fly   744 LIAKKGSKEKVKTMLQDFLRDQRNSAVFQNIQNPLNPSFRCSGVTPDRCKVMDSKMRPLWVVFEN 808
            ...:|...:|....|::|.:|      .:....||||:....|:..|.|....|...||.:.|.|
  Rat   910 DAQRKDVLKKEIGSLEEFFKD------IKTCHLPLNPALCVKGIDRDACSYFTSNALPLKITFIN 968

  Fly   809 ADVNASDVHIIFKNGDDLRQDMLTLQMLRVMDQLWKRDGMDFRMNIYNCISMEKSLGMIEVVRHA 873
            |:....::.:|||.|||||||||.||:::|||.:|.::|:|.:|.||.|::..|:.|.||:|..|
  Rat   969 ANPMGKNISVIFKAGDDLRQDMLVLQIIQVMDNVWLQEGLDMQMIIYGCLATGKAQGFIEMVPDA 1033

  Fly   874 ETIANIQKEKGMFSATSPFKKGSLLSWLKEHNKPADKLNKAINEFTLSCAGYCVATYVLGVADRH 938
            .|:|.|....|:.   .|.|:.::..|..:||...:...||:..|..||||:||.|::|||.|||
  Rat  1034 VTLAKIHLHSGLI---GPLKENTIKKWFSQHNHLKEDYEKALRNFFYSCAGWCVVTFILGVCDRH 1095

  Fly   939 SDNIMVKRNGQLFHIDFGHILGHFKEKLGVRRERVPFVLTHDFVYVINKGFNDRESKEFCHFQEL 1003
            :||||:.::|.:||||||..|||.:...|::|:|.||:.|.:..|.|.:|  .:.::.|..|.||
  Rat  1096 NDNIMLTKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEMEYFITEG--GKNTQHFQDFVEL 1158

  Fly  1004 CERAFLVLRKHGCLILSLFSMMISTGLPELSSEKDLDYLRETLVLDYTEEKAREHFRAKFSEALA 1068
            |.||:.::|||..|:|||..||:..|||||...:||.|:.:.|....|:.:|..||..|..::| 
  Rat  1159 CCRAYNIVRKHSQLLLSLLEMMLHAGLPELRGIEDLKYVHDNLRPQDTDLEATSHFTTKIKQSL- 1222

  Fly  1069 NSWKTSLNWASHNFSK 1084
            ..:...||...|..::
  Rat  1223 ECFPVKLNNLIHTLAQ 1238

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi3K92ENP_001262770.1 PI3K_p85B 56..132 CDD:295322 10/49 (20%)
PI3K_rbd 200..307 CDD:197540 19/140 (14%)
C2_PI3K_class_I_beta_delta 339..517 CDD:176075 47/291 (16%)
PI3Ka_I 552..723 CDD:238444 55/174 (32%)
PI3Kc_I 727..1084 CDD:270709 135/363 (37%)
Pik3c2gNP_446375.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..32
PI3K_rbd <310..368 CDD:295323 13/82 (16%)
C2A_PI3K_class_II 535..697 CDD:175979 38/204 (19%)
PI3Ka 712..879 CDD:294194 55/172 (32%)
PKc_like 886..1238 CDD:304357 135/363 (37%)
PX_domain 1267..1367 CDD:295365
C2 1389..1501 CDD:301316
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166339938
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D204282at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.750

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