Protein Alignment Pi3K92E and Pik3c2g

DIOPT Version :10

• Sequence 1: NP_650902.1
• Gene: Pi3K92E / 42446
• FlyBaseID: FBgn0015279
• Length: 1088
• Species: Drosophila melanogaster
• Sequence 2: NP_446375.2
• Gene: Pik3c2g / 116720
• RGDID: 620231
• Length: 1505
• Species: Rattus norvegicus
• Alignment Length: 1185
• Identity: 293/1185 - (24%)
• Similarity: 473/1185 - (39%)
• Gaps: 297/1185 - (25%)

  Fly    89 EACEYQV-------YGISTFNIEPYTDETKRLSEVQPYFGILSLGERTDTTSFSSDYELTKMVNG 146
            |.|.|.|       :..|.::::...|..::.|      |...|.|  .:..||.|..|.:....
  Rat   162 EHCNYYVELENNIPHHYSPYSMDSIPDSEEKGS------GDADLVE--PSLVFSKDSFLPRASEN 218

  Fly   147 MIGTTFDHNRTHGSP-EI----DDFRLYMTQTCDNIELERSAY-----------------TWQQR 189
            |   :.:.....|.| ||    ......:...|:|:...|..|                 .:..|
  Rat   219 M---SVESTEPIGCPLEIVEAPQGSNKSLASFCNNVTKIRGLYHASDTNSNSGKIWAITTAYPSR 280

  Fly   190 LLYEHPLRLANSTKMPELIRERHPTRTFLIVVKNENDQSTFTLSVNEQDTPFSLTESTLQKMNRS 254
            |..:...|:..||.....:....|...:|:   .:.......|..|||.:|
  Rat   281 LFADTQFRVKISTDNSAQLLLLKPPANYLV---KDLIAEILLLCANEQLSP-------------- 328

  Fly   255 QMKMNDRTSDYILKVSGRDEYL-----LGDYPLIQ-----------------------------F 285
                    .:|:|.:.|.:|:|     ||.:.:.|                             .
  Rat   329 --------KEYLLSICGSEEFLQTDHCLGSHKIFQKSKSVIQLHLQRSRDTPGKLSRKRDDDRSR 385

  Fly   286 LYIQEMLSDSAVPNVVLQSVYRLESYINHHNEQAMVTKRPLPKKRTVHLHKSISSLWDMGNY--- 347
            :::.::|..:.:..:..|.:..:....|.|.|..:.|:..:.:       |.:||::..|.:
  Rat   386 VHLNQLLEFTHIWKISRQCLSTVMKSYNLHVEHLLKTQEDVEE-------KPLSSMFSCGRHPPQ 443

  Fly   348 -----------------------------FQLTL---------HS---------ISNVNFDKTRA 365
                                         .:|||         |.         |.||..:.:|:
  Rat   444 PHGNDIIEDVRNICSVLGCIETKQVSDAVKELTLILQRPSQNFHQNSETSKKGFIENVTSELSRS 508

  Fly   366 L---------------------------KVGVH------VCLYH--------------------- 376
            |                           ..|:|      ||..|
  Rat   509 LHQLVDVYCSSFCTDFRPARAPGGVSRDHAGLHSHLSFTVCSLHNVPETWAHSYKAFSFSCWLTY 573

  Fly   377 GDKKLCAQRSTDS-PNGNFDTFLFN-DLVMDFDIQMRNLPRMTRLCIVIFEVTKMSRSKKSSNNK 439
            ..||||..:|..| |.....:|..| :.:::|.:::::|||.:.|.|.:|.:...:.|
  Rat   574 AGKKLCQVKSCRSLPVTKSFSFSVNWNEIINFPLEIKSLPRESMLVIKLFGIDSATHS------- 631

  Fly   440 DIALKDVPYNKNPLAWVNTTIFDHKDILRTGRHTLYTWTYADDIQSVEVFHPLG------TIEPN 498
                      .|.|||....:|..:.                        .|||      |::..
  Rat   632 ----------ANLLAWTCLPLFPKEK------------------------SPLGSRLLSMTLQSE 662

  Fly   499 PRKEECA--LVDLTFLSSGTGTVRYPSEEVVLQYAADREQVNRLQRQLAGPEKPIKELKELMANY 561
            |..|..|  :.|.:..:..|..:.:|:  ...:|.....:.||...| ..|.:.:|.:..|....
  Rat   663 PPIEMMAPGVWDGSQPTPLTLQIDFPA--ATWEYVKPETEENRTDHQ-EPPRECLKHIARLSQKQ 724

  Fly   562 TGLDKIYEMVDQDRNAIWERR---NDILRELPEELSILLHCVYWKERDDVADMWYLLKQWPLISI 623
            :.|    .:..:.|..:|..|   |:....||   .:|.....|.| ..|::|..:|::|.....
  Rat   725 SPL----LLSVEKRRYLWFYRFYCNNENSSLP---LVLGSAPGWDE-GTVSEMHAVLRRWTFSHP 781

  Fly   624 ERSLELLDYAYPDPAVRRFAIRCLHFLKDEDLLLYLLQLVQAIKHESYLESDLVVFLLERALRNQ 688
            ..:|.||...:||..:|..|::.|..|..::||..|.|||||:|.|..|||.||..||.|:|::.
  Rat   782 LEALGLLTSRFPDQDIREVAVQQLDNLLTDELLDCLPQLVQAVKFEWSLESPLVELLLHRSLQSI 846

  Fly   689 RIGHYFFWHLRSEMQTPSMQTRFGLLLEVYLKGCKHH--VAPLRKQLHVL-------EKLKQGSL 744
            |:.|..||.||........::.:..||.. |:.|...  :..|.|:..::       ||:|....
  Rat   847 RVAHRLFWLLRDAQGEDYFKSWYQELLAA-LQFCAGEALIEELSKEQKLVKLLGDIGEKVKSAGD 910

  Fly   745 IAKKGSKEKVKTMLQDFLRDQRNSAVFQNIQNPLNPSFRCSGVTPDRCKVMDSKMRPLWVVFENA 809
            ..:|...:|....|::|.:|      .:....||||:....|:..|.|....|...||.:.|.||
  Rat   911 AQRKDVLKKEIGSLEEFFKD------IKTCHLPLNPALCVKGIDRDACSYFTSNALPLKITFINA 969

  Fly   810 DVNASDVHIIFKNGDDLRQDMLTLQMLRVMDQLWKRDGMDFRMNIYNCISMEKSLGMIEVVRHAE 874
            :....::.:|||.|||||||||.||:::|||.:|.::|:|.:|.||.|::..|:.|.||:|..|.
  Rat   970 NPMGKNISVIFKAGDDLRQDMLVLQIIQVMDNVWLQEGLDMQMIIYGCLATGKAQGFIEMVPDAV 1034

  Fly   875 TIANIQKEKGMFSATSPFKKGSLLSWLKEHNKPADKLNKAINEFTLSCAGYCVATYVLGVADRHS 939
            |:|.|....|:.   .|.|:.::..|..:||...:...||:..|..||||:||.|::|||.|||:
  Rat  1035 TLAKIHLHSGLI---GPLKENTIKKWFSQHNHLKEDYEKALRNFFYSCAGWCVVTFILGVCDRHN 1096

  Fly   940 DNIMVKRNGQLFHIDFGHILGHFKEKLGVRRERVPFVLTHDFVYVINKGFNDRESKEFCHFQELC 1004
            ||||:.::|.:||||||..|||.:...|::|:|.||:.|.:..|.|.:|  .:.::.|..|.|||
  Rat  1097 DNIMLTKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEMEYFITEG--GKNTQHFQDFVELC 1159

  Fly  1005 ERAFLVLRKHGCLILSLFSMMISTGLPELSSEKDLDYLRETLVLDYTEEKAREHFRAKFSEALAN 1069
            .||:.::|||..|:|||..||:..|||||...:||.|:.:.|....|:.:|..||..|..::| .
  Rat  1160 CRAYNIVRKHSQLLLSLLEMMLHAGLPELRGIEDLKYVHDNLRPQDTDLEATSHFTTKIKQSL-E 1223

  Fly  1070 SWKTSLNWASHNFSK 1084
            .:...||...|..::
  Rat  1224 CFPVKLNNLIHTLAQ 1238

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K92E	NP_650902.1	PI3K_p85B	56..132	CDD:470589	10/49 (20%)
		PI3K_rbd	200..307	CDD:197540	19/140 (14%)
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	47/291 (16%)
		PI3Ka_I	552..723	CDD:238444	53/173 (31%)
		PI3Kc_I	727..1084	CDD:270709	135/363 (37%)
Pik3c2g	NP_446375.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..32
		C2A_PI3K_class_II	535..697	CDD:175979	38/204 (19%)
		PI3Ka	712..879	CDD:412275	53/175 (30%)
		Protein Kinases, catalytic domain	886..1238	CDD:473864	135/363 (37%)
		G-loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	954..960		1/5 (20%)
		Catalytic loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	1090..1098		5/7 (71%)
		Activation loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	1109..1135		13/25 (52%)
		PX_domain	1267..1367	CDD:470617
		C2	1389..1501	CDD:472691