DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K92E and Pi4kb

DIOPT Version :9

Sequence 1:	NP_001262770.1	Gene:	Pi3K92E / 42446	FlyBaseID:	FBgn0015279	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	NP_001280644.1	Gene:	Pi4kb / 107650	MGIID:	1334433	Length:	816	Species:	Mus musculus

Alignment Length:	665	Identity:	150/665 - (22%)
Similarity:	243/665 - (36%)	Gaps:	188/665 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   479 YADDIQSVEVFHPLGT----------IEPNPRKEECALVDLTFLSSGTGTVRYPSEEVVLQYAAD 533
            |:.|:......|..||          ::|..||.|     |..||....|...||:....:..:|
Mouse   219 YSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRE-----LPTLSPAPDTGLSPSKRTHQRSKSD 278

  Fly   534 R----EQVNRLQRQLAGPEKPIKELKELMANYTGLDKIYE---------------MVDQDRNAIW 579
            .    ...:.|:|..:.| |...|.:||.::...:|..:.               |....|.|..
Mouse   279 ATASISLSSNLKRTASNP-KVENEDEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATL 342

  Fly   580 ERRNDILRELPEELSILLHCVYWKERDDVADMWYLLKQWPLISIERSLELLDYAYPDPAVRRFAI 644
            ..:....:.|..|||:|.|.:       .|.:|                     .|........:
Mouse   343 PTKEQKTQRLISELSLLNHKL-------PARVW---------------------LPTAGFDHHVV 379

  Fly   645 RCLH----FLKDEDLLLYLLQLVQAIKHESYLESDLVVFLLERALRN---------------QRI 690
            |..|    .|..:|...||: .|:.::.|::..:.:...:.|..:|:               ||.
Mouse   380 RVPHTQAVVLNSKDKAPYLI-YVEVLECENFDTTSVPARIPENRIRSTRSVENLPECGITHEQRA 443

  Fly   691 GHYF----------FWHLR--SEMQTPSMQTRFGLLLEVYLKGCKHHVAPLRKQLHVLEKLKQGS 743
            |.:.          .|.:.  .|:|..        |.||:...|              :.:.|.|
Mouse   444 GSFSTVPNYDNDDEAWSVDDIGELQVE--------LPEVHTNSC--------------DNISQFS 486

  Fly   744 L--IAKKGSKEKVKTMLQD---------------FLRDQRN-SAVFQNIQNPLNPSFRCSGVTPD 790
            :  |..:.|||.|.....|               |.||..: |||  .::.|.....|
Mouse   487 VDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAV--ALKEPWQEKVR------- 542

  Fly   791 RCKVMDSKMR--------PLWVVFENADVNASDVHIIFKNGDDLRQDMLTLQMLRVMDQLWKRDG 847
                   ::|        |.|.:          :.:|.|.||||||::|..|:|:.:..:|:::.
Mouse   543 -------RIREGSPYGHLPNWRL----------LSVIVKCGDDLRQELLAFQVLKQLQSIWEQER 590

  Fly   848 MDFRMNIYNCISMEKSLGMIEVVRHAETIANIQKEKGMFSATSPFKKGSLLSW-LKEHNK-PADK 910
            :...:..|..:.:....||||.|.:|.:|..::|:..:          |||.: |:||.. ..:.
Mouse   591 VPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQL----------SLLDYFLQEHGSYTTEA 645

  Fly   911 LNKAINEFTLSCAGYCVATYVLGVADRHSDNIMVKRNGQLFHIDFGHILGHFKEKLGVRRERVPF 975
            ...|...|..||||||:..|:|.|.|||:.||::...|.:.|||||.||......||.  |...|
Mouse   646 FLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGF--ETSAF 708

  Fly   976 VLTHDFVYVINKGFNDRESKEFCHFQELCERAFLVLRKHGCLILSLFSMM-ISTGLPELSSEKDL 1039
            .||.:||.|:. |.|   ...|.:::.|..:..:..|||...::.:..:| ..:.||.......:
Mouse   709 KLTTEFVDVMG-GLN---GDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTI 769

  Fly  1040 DYLRETLVLDYTEEK 1054
            ..|:|...:..|||:
Mouse   770 RNLKERFHMSMTEEQ 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K92E	NP_001262770.1	PI3K_p85B	56..132	CDD:295322
		PI3K_rbd	200..307	CDD:197540
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	12/47 (26%)
		PI3Ka_I	552..723	CDD:238444	35/216 (16%)
		PI3Kc_I	727..1084	CDD:270709	94/357 (26%)
Pi4kb	NP_001280644.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		Interaction with ACBD3. /evidence=ECO:0000250\|UniProtKB:Q9UBF8	2..68
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	101..120
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..318		18/73 (25%)
		PI4Kc_III_beta	529..816	CDD:270712	83/298 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810