DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K92E and pik3c2b

DIOPT Version :9

Sequence 1:	NP_001262770.1	Gene:	Pi3K92E / 42446	FlyBaseID:	FBgn0015279	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	XP_031752708.1	Gene:	pik3c2b / 100489532	-ID:	-	Length:	598	Species:	Xenopus tropicalis

Alignment Length:	510	Identity:	202/510 - (39%)
Similarity:	294/510 - (57%)	Gaps:	30/510 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   586 LRELPEELSILLHCVYWKERDDVADMWYLLKQWPLISIERSLELLDYAYPDPAVRRFAIRCLHFL 650
            ||.||.:   |.....| :...:.|:..||.||..::...:|.||...|||..||..|.:.:..:
Frog    15 LRSLPLQ---LFRAPGW-QWACLPDISALLGQWTEMNHHDALRLLHARYPDQEVRDTAKQWIDSI 75

  Fly   651 KDEDLLLYLLQLVQAIKHESYLESDLVVFLLERALRNQRIGHYFFWHLRSEMQTPSMQTRFGLLL 715
            .|.:||.||.|||||:|:|.||:|.||.|||:||:.:.||.|||||.|:..::......|:..||
Frog    76 SDAELLEYLPQLVQALKYECYLDSPLVRFLLKRAICDLRITHYFFWLLKDCLKDSQFSIRYQYLL 140

  Fly   716 EVYLKGCKHHVAPLRKQ-------LHVLEKLKQGSLIAKKGSKEKVKTMLQDFLRDQRNSAVFQN 773
            ...|..|.   ..||::       ::.|.||.|.   .::|:....:.:|::.|.:.:.   |.|
Frog   141 AALLCCCG---KGLREEFDHQCWLVNTLSKLAQK---VREGAPSSRRAILREGLEEVKR---FFN 196

  Fly   774 IQN----PLNPSFRCSGVTPDRCKVMDSKMRPLWVVFENADVNASDVHIIFKNGDDLRQDMLTLQ 834
            :..    |||||....|:.|:.|...:|...||.:.|:|.|....::.||||.||||||||||||
Frog   197 VNGSCRLPLNPSLLVKGIVPEECSHFNSNAVPLKLTFQNVDTLGGNIQIIFKCGDDLRQDMLTLQ 261

  Fly   835 MLRVMDQLWKRDGMDFRMNIYNCISMEKSLGMIEVVRHAETIANIQKEKGMFSATSPFKKGSLLS 899
            |:|:|:::|.::|:|.:|.|:.|.|..:..||:|::..|||:..||.|.|:   |..|....|..
Frog   262 MIRIMNKIWVQEGLDMQMVIFRCFSTGRGRGMVEMIPSAETLRKIQAEHGV---TGSFMDRPLAD 323

  Fly   900 WLKEHNKPADKLNKAINEFTLSCAGYCVATYVLGVADRHSDNIMVKRNGQLFHIDFGHILGHFKE 964
            ||::||...::..||:..|..||||.||||||||:.|||:||||:|.:|.:||||||..|||.:.
Frog   324 WLQKHNPTVNEYEKAVVNFIYSCAGCCVATYVLGICDRHNDNIMLKTSGHMFHIDFGRFLGHAQM 388

  Fly   965 KLGVRRERVPFVLTHDFVYVINKGFNDRESKEFCHFQELCERAFLVLRKHGCLILSLFSMMISTG 1029
            ...::|:|.|||.|.|..||||.|  |:.|..|..|.:||.:|:.::|||..|.|:|..:|:|.|
Frog   389 FGNIKRDRAPFVFTSDMAYVINGG--DKPSSRFQDFVDLCCQAYNLIRKHTHLFLNLLGLMLSCG 451

  Fly  1030 LPELSSEKDLDYLRETLVLDYTEEKAREHFRAKFSEALANSWKTSLNWASHNFSK 1084
            :||||..:||.|:.:.|....:|..|..:| .:..|:...|..|.||:..||.::
Frog   452 IPELSDLRDLKYVYDALRPQDSESDAATYF-TRLIESSLGSVATKLNFFIHNLAQ 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K92E	NP_001262770.1	PI3K_p85B	56..132	CDD:295322
		PI3K_rbd	200..307	CDD:197540
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075
		PI3Ka_I	552..723	CDD:238444	54/136 (40%)
		PI3Kc_I	727..1084	CDD:270709	147/367 (40%)
pik3c2b	XP_031752708.1	PI3Ka	11..146	CDD:412275	54/134 (40%)
		PKc_like	152..505	CDD:419665	146/364 (40%)
		PX_domain	534..>593	CDD:413376
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010