DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K92E and pik3cg

DIOPT Version :9

Sequence 1:	NP_001262770.1	Gene:	Pi3K92E / 42446	FlyBaseID:	FBgn0015279	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	XP_012814080.1	Gene:	pik3cg / 100158519	XenbaseID:	XB-GENE-1011009	Length:	1126	Species:	Xenopus tropicalis

Alignment Length:	1002	Identity:	336/1002 - (33%)
Similarity:	525/1002 - (52%)	Gaps:	114/1002 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 ELTKMVNGMIG-TTFDHNRTHGSPEIDDFRLYMTQ----TCDNIELERSAYTWQQRLLYEHPLRL 198
            |..|.:|.:|| ...|.:..|      |..|..|:    |...|||.|.    ..||....|...
Frog   165 EYQKTLNYLIGYDVTDVSNVH------DDELEFTRRRLVTPRMIELSRR----DARLYSMDPWVT 219

  Fly   199 ANSTKMPELIRERHPTRTFLIVVKNENDQSTFTLSVNEQDTPFSLTESTLQKM--NRSQMKMNDR 261
            ..|  :||.:.:|..:.:..|::  ....::.|:.|:..|||..:..|...||  .:|.:.:::.
Frog   220 CKS--LPEYLCQRIISNSIFIII--HKGMTSHTIRVSIDDTPDVILHSFFTKMAKKKSLLDISEE 280

  Fly   262 TS--DYILKVSGRDEYLLGDYPLIQFLYIQEMLSDSAVPNVVLQ-------SVYRLESY------ 311
            .|  |::|:|.|||||::|:.|:..|.:|::.:.:....::||:       ...:.|.:
Frog   281 NSELDFVLRVCGRDEYIIGNAPIKDFHWIRQCIKNGQEIHLVLEKPPDPLMDEVQKEQWPLVDDC 345

  Fly   312 --INHHNEQAMVTKRPLPKKRTVHLHKSISSLWDMGNYFQLTLHSISNVNFDKTRALKVGVHVCL 374
              :..::||..:..:...|..|:       ||||....|::.:..|......|...|...|...:
Frog   346 TGVTGYHEQLTIEGKDHEKIFTI-------SLWDCNRKFRVKIIGIDIPVLPKNTELIAFVEANI 403

  Fly   375 YHGDKKLCAQRSTDSPNGNF-DTFLFNDLVMDFDIQMRNLPRMTRLCIVIFEVTKMSRSKKS-SN 437
            .||.:.|..:|:|..|   | :..|:|.. ::|||::::||:...|.:.||.....:.|.|| ..
Frog   404 QHGQQVLSQRRTTCKP---FTEEVLWNSW-LEFDIKIKDLPKGALLNLQIFCGKAPTASNKSIVQ 464

  Fly   438 NKDIALKDVPYNKNPLAWVNTTIFDHKDILRTGRHTLYTWTY-----------ADDIQSVEVFHP 491
            :.:....|.......|.:||..:.||:.:||.|.:.|:.|..           ||.:.|.
Frog   465 SPESTASDSKCKNQLLYYVNLLLIDHRFLLRQGEYVLHMWKIPGKGEEQGSINADKLTSA----- 524

  Fly   492 LGTIEPNPRKEECALVDLTFLSSGTGTVRYPSEEVVLQYAADR---EQVNRLQRQLAGPEKPIKE 553
                 .||.||....:.:: |......|..|..::|.....:|   |..|:|:          |:
Frog   525 -----TNPDKETSMAISIS-LDKYCHPVALPKHKLVCDPELERPRTEMPNQLR----------KQ 573

  Fly   554 LKELMANYTGLDKIYEMVDQDRNAIWERRNDILRELPEELSILLHCVYWKERDDVADMWYLLKQ- 617
            |:|::|.    |.::.:..:|:..:|..|::|::. ||....||..|.|.:::.||..:.||.:
Frog   574 LEEIIAT----DPLHPLTPEDKELLWHFRSEIVKH-PEAYPKLLSSVKWGQQEMVAKTYQLLSKR 633

  Fly   618 --WPLISIE--RSLELLDYAYPDPAVRRFAIRCLHFLKDEDLLLYLLQLVQAIKHESYLESDLVV 678
              |...|::  .:::|||..:.|..||..|::.|..|:|:|:|.||||||||:|.|.|.:|.|..
Frog   634 EAWDDCSLDVGLTIQLLDCNFSDENVRAMAVQKLESLQDDDVLHYLLQLVQAVKFEPYHDSALSR 698

  Fly   679 FLLERALRNQRIGHYFFWHLRSEM-QTPSMQTRFGLLLEVYLKGC-KHHVAPLRKQLHVLEKLKQ 741
            |||:|||:::||||:.||.||||: |:...|.||.::||.||:|| |..:....:|:.|.|.|.:
Frog   699 FLLKRALQSKRIGHFLFWFLRSEIAQSMHYQQRFAVILEAYLRGCGKAMLDDFTRQVQVTEILHK 763

  Fly   742 GSLIAKKGSKEK------VKTMLQDFLRDQRNSAVFQNIQN----PLNPSFRCSGVTPDRCKVMD 796
            .::..|..|.||      |.|.|:..|...:||.:...:.:    |.:|..|...:..::||||.
Frog   764 VTMEIKSVSAEKYDVTSQVITQLRQKLEKLQNSKLPDKLPDSFRVPYDPGLRAGSLVVEKCKVMA 828

  Fly   797 SKMRPLWVVFENADVNA---SDVHIIFKNGDDLRQDMLTLQMLRVMDQLWKRDGMDFRMNIYNCI 858
            ||.:|||:.|:.:|..|   ..:.||||:|||||||||.||:||:|..:|:.:.:|..:..|.||
Frog   829 SKKKPLWLEFKCSDTTALSNETIGIIFKHGDDLRQDMLILQILRIMGSIWEAESLDLCLLPYGCI 893

  Fly   859 SMEKSLGMIEVVRHAETIANIQKEKGMFSATSPFKKGSLLSWLKEHNKPADKLNKAINEFTLSCA 923
            |....:||||:|:.|.|||.||  :.....|..||...|..||||.....:|.:.|:..|..|||
Frog   894 STGNKIGMIEIVKDATTIAQIQ--QSTVGNTGAFKDEVLSQWLKEKCPIEEKFSAAVERFVYSCA 956

  Fly   924 GYCVATYVLGVADRHSDNIMVKRNGQLFHIDFGHILGHFKEKLGVRRERVPFVLTHDFVYVINKG 988
            ||||||:|||:.|||:|||||..:|.|||||||||||::|..||:.:||||||||.||:||:...
Frog   957 GYCVATFVLGIGDRHNDNIMVTESGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLYVMGTS 1021

  Fly   989 FNDRESKEFCHFQELCERAFLVLRKHGCLILSLFSMMISTGLPELSSEKDLDYLRETLVLDYTEE 1053
             ..:.|:.|..||::|.:|:|.||.|..|::.|||||:.||:|:|:|::|::|:|::|.:...||
Frog  1022 -GKKTSQYFNKFQDVCVKAYLALRHHTNLMIILFSMMLMTGMPQLTSKEDIEYIRDSLTVGKNEE 1085

  Fly  1054 KAREHFRAKFSEALANSWKTSLNWASH 1080
            .|::||..:........|....||..|
Frog  1086 SAKKHFLDQIEVCRDKGWTVQFNWFLH 1112

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K92E	NP_001262770.1	PI3K_p85B	56..132	CDD:295322
		PI3K_rbd	200..307	CDD:197540	29/117 (25%)
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	48/190 (25%)
		PI3Ka_I	552..723	CDD:238444	72/177 (41%)
		PI3Kc_I	727..1084	CDD:270709	156/367 (43%)
pik3cg	XP_012814080.1	PI3K_rbd	221..328	CDD:413336	29/110 (26%)
		C2_PI3K_class_I_gamma	366..546	CDD:176044	49/201 (24%)
		PI3Ka_I	568..744	CDD:238444	73/190 (38%)
		PI3Kc_IB_gamma	748..1118	CDD:270627	156/368 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10048
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X531
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.110