Protein Alignment Pi3K92E and pi4kb

DIOPT Version :9

• Sequence 1: NP_001262770.1
• Gene: Pi3K92E / 42446
• FlyBaseID: FBgn0015279
• Length: 1088
• Species: Drosophila melanogaster
• Sequence 2: NP_001096204.1
• Gene: pi4kb / 100124755
• XenbaseID: XB-GENE-997612
• Length: 806
• Species: Xenopus tropicalis
• Alignment Length: 881
• Identity: 189/881 - (21%)
• Similarity: 315/881 - (35%)
• Gaps: 271/881 - (30%)

  Fly   234 VNEQDTPFSLTESTLQKMNRSQMKMNDRTSDYILKVSGRDEYLLGDYPL-IQFLYIQEMLSDSAV 297
            :.|::.  ||.:....|..|.:.|.|.....::|::.   |..|.|..: |.:||      :|..
 Frog   105 ITEEEE--SLIDINSVKSARRRQKNNSAKQSWLLRLF---ECKLFDVSMAISYLY------NSKE 158

  Fly   298 PNVVLQSVYRLESYINHHNEQAMVTKRPLPKKRTVHLHKSISSLWDMGNYFQLTLHSISNVNFDK 362
            |.|        ::||                                ||  :|......:|:|..
 Frog   159 PGV--------QAYI--------------------------------GN--RLFCFRYEDVDFYL 181

  Fly   363 TRALKVGVHVCLYHGD--KKLCAQRSTDSPNGNFD-TFLFNDLVMDFDIQMRNLPRMTRLCIVIF 424
            .:.|.:.:|:....||  |.....|...|.|.:.. .:|......|..|..:...|.|:|..:|
 Frog   182 PQLLNMYIHMDEDVGDAIKPYVVHRCRQSINFSLQCAWLLGAYSSDMHISTQRHSRGTKLRKLI- 245

  Fly   425 EVTKMSRSKKSSNNKDIALKDVPYNKNPLAWV-NTTIFDHKDILRTGRHTLYTWTYADDIQSVEV 488
                :|...|.::.|    :::|    ||:.. :|.:...|   ||.:.     :.:|...|:.:
 Frog   246 ----LSDELKPAHKK----REIP----PLSLAPDTGLSPSK---RTHQR-----SKSDATVSISL 290

  Fly   489 FHPLGTIEPNPRKEECALVDLTFLSSGTGTVRYPSEEVVLQYAADREQVNRLQ---RQLAGPEKP 550
            ...|.....||:.|                    :::..::.|.:||.:..|.   ::||  ..|
 Frog   291 SSNLKRTSSNPKVE--------------------NDDEPVRLAPEREFIKSLMAIGKRLA--TLP 333

  Fly   551 IKELKELMANYTGLDKIYEMVDQDRNAIWERRNDILRELPEELSILLHCVYWKERDDVADMWYLL 615
            .||.|                              .:.|..|||:|.|.:       .|.:|
 Frog   334 TKEQK------------------------------TQRLISELSLLNHKL-------PARVW--- 358

  Fly   616 KQWPLISIERSLELLDYAYPDPAVRRFAIRCLH----FLKDEDLLLYLLQLVQAIKHESYLESDL 676
                              .|........:|..|    .|..:|...||: .|:.::.|::..|.:
 Frog   359 ------------------LPTAGFDHHVVRVPHTQAVVLNSKDKAPYLI-YVEVLECENFETSLV 404

  Fly   677 VVFLLERALRNQR---------IGHYFFWHLRSEMQTPSMQT--------------RFGLLL--- 715
            .|.:.|..:|:.|         |.|        |.:..|..|              ..|.|.
 Frog   405 PVRIPENRIRSTRSVENLPECGITH--------EQRASSFTTVPNYDNDDEAWSVDDIGELQVEL 461

  Fly   716 -EVYLKGCKHHVAPLRKQLHVLEKLKQGSL--IAKKGSKEKVKTMLQDFLR--DQRNSAVFQNIQ 775
             |::...|              :.:.|.|:  |..:.||:.|      |:.  |.|.....|...
 Frog   462 PELHTNSC--------------DNISQFSVDSITSQESKDPV------FIAAGDIRRRLSEQLAH 506

  Fly   776 NPLNPSFRCSGVTPDRCKVMD---SKMR-----------PLWVVFENADVNASDVHIIFKNGDDL 826
            .|  .:||.....|....:.:   .|:|           |.|.:          :.:|.|.||||
 Frog   507 TP--TTFRRDPEDPSAVALKEPWQEKVRRIREGSPYGHFPNWRL----------LSVIVKCGDDL 559

  Fly   827 RQDMLTLQMLRVMDQLWKRDGMDFRMNIYNCISMEKSLGMIEVVRHAETIANIQKEKGMFSATSP 891
            ||::|..|:|:.:..:|:.:.:...:..|..:.:....||||.|.:|.:|..::|:..:
 Frog   560 RQELLAYQVLKQLQSIWESERVPLWIRPYKILVISADSGMIEPVVNAVSIHQVKKQSQL------ 618

  Fly   892 FKKGSLLSW-LKEHNK-PADKLNKAINEFTLSCAGYCVATYVLGVADRHSDNIMVKRNGQLFHID 954
                |||.: |:||.. ..:....|...|..||||||:..|:|.|.|||:.||::...|.:.|||
 Frog   619 ----SLLDYFLQEHGSCTTEAFLTAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHID 679

  Fly   955 FGHILGHFKEKLGVRRERVPFVLTHDFVYVINKGFNDRESKEFCHFQELCERAFLVLRKHGCLIL 1019
            ||.||......||.  |...|.||.:||.|:. |.|   ...|.:::.|..:..:..|||...::
 Frog   680 FGFILSSSPRNLGF--ETSAFKLTSEFVDVMG-GLN---GDMFNYYKMLMLQGLIAARKHMDRVV 738

  Fly  1020 SLFSMM-ISTGLPELSSEKDLDYLRETLVLDYTEEK 1054
            .:..:| ..:.||.......:..|:|...::.|||:
 Frog   739 QIVEIMQQGSQLPCFHGSSTIRNLKERFHMNMTEEQ 774

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K92E	NP_001262770.1	PI3K_p85B	56..132	CDD:295322
		PI3K_rbd	200..307	CDD:197540	17/73 (23%)
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	36/181 (20%)
		PI3Ka_I	552..723	CDD:238444	33/201 (16%)
		PI3Kc_I	727..1084	CDD:270709	93/349 (27%)
pi4kb	NP_001096204.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	69..104
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	253..310		14/92 (15%)
		PI4Kc_III_beta	519..806	CDD:270712	79/282 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910