DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K92E and pik3cb

DIOPT Version :9

Sequence 1:	NP_001262770.1	Gene:	Pi3K92E / 42446	FlyBaseID:	FBgn0015279	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	XP_005157523.1	Gene:	pik3cb / 100002263	ZFINID:	ZDB-GENE-030131-1904	Length:	1080	Species:	Danio rerio

Alignment Length:	1100	Identity:	414/1100 - (37%)
Similarity:	632/1100 - (57%)	Gaps:	73/1100 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 PPCMRFSVNLWKNEMLNWVDLIC---LLPNGFLLELRVNPANTIQVIKVEMVNQAKQMPLGYVIK 88
            ||.....::||....|:..|.:.   |||.|..:::.|...:|||.||:.:..:|:..||..::.
Zfish     2 PPAKTDQLDLWAESGLDGDDQVMVDFLLPTGIYIQMEVPRESTIQHIKLLLWKEAQTYPLFSLLG 66

  Fly    89 EACEYQVYGISTFNI-EPYTDETKRLSEVQPYFGILSLGERTDTTSFSSDYELTKMVNGMIGTTF 152
            |...:....::...: |...|||:||.:|:|:..:|.|..|   ....::..|...:..:||...
Zfish    67 EMEGHMFECVNQAAVHEELEDETRRLCDVRPFLPVLKLITR---NCGRAERLLDSKIGVLIGKGL 128

  Fly   153 DHNRTHGSPEIDDFRLYMTQTCDNIELERSAYTWQQRLLYEHPLRLANSTKMPELIRERHPTRTF 217
            .........|:.|||..|.:..:....:....:|.|.|...:..:| :::.:..|| ||| ....
Zfish   129 HELDALQDQEVKDFRSKMKRISEEKMQQMQMMSWGQWLRSSYSPQL-DTSSLDNLI-ERH-EGII 190

  Fly   218 LIVVKNENDQSTFTLSVNEQDTPFSLTESTLQKMNRSQMKMND--RTSDYILKVSGRDEYLLGDY 280
            .|.:..:..|.|.:|.|:...|...:.:..|:|...:.....|  ..|:|:|:||.|.|:|..||
Zfish   191 KITMHYDQSQDTASLKVSLNCTVSEVMDHALKKWQTTHGPEEDIGARSNYVLRVSDRLEFLFEDY 255

  Fly   281 PLIQFLYIQEMLSDSAVPNV------VLQSVYRLE-----SYINHHNEQAMVTKRP----LPKKR 330
            ||||:.||:..||....|::      :::|::..|     |.:      |..|..|    .||||
Zfish   256 PLIQYKYIRACLSTGENPHLTVVHFDIVKSMFEKEIATVGSVL------ARKTSNPPLPLPPKKR 314

  Fly   331 TVHLHKSISS-----------LWDMGNYFQLTLHSISNVNFDKTRALKVGVHVCLYHGDKKLCAQ 384
            ...:..|..|           :|.:.:.|::.|...:.||.:.  |.|:.|...|:||.:.|| :
Zfish   315 QTTVRTSSMSASQLPQQLHTCVWKVHSLFRINLVKANKVNAED--AAKIQVRAGLFHGTELLC-K 376

  Fly   385 RSTDSPNGNFDTFLFNDLVMDFDIQMRNLPRMTRLCIVIFEV---TKMSRSKKSSN-NKDIALKD 445
            .:..:.:.:....::|. .::|||.:.:||||.|||..|:.|   .|..||.|::: ||...::.
Zfish   377 TAVSNESSSRSEHVWNK-TLEFDIPVCDLPRMARLCFAIYAVMDKVKKQRSTKNTHLNKYQTIRK 440

  Fly   446 VPYNKNPLAWVNTTIFDHKDILRTGRHTLYTW-TYADDIQSVEVFHPLGTIEPNPRKEECALVDL 509
            ......|:|||||.:||::..|:||...|:.| ::.|:::  |:.:|:|||:.||..|....:.:
Zfish   441 AGKVHYPIAWVNTMVFDYRGQLKTGDIILHCWSSFPDELE--EMLNPIGTIQTNPYTENATELHI 503

  Fly   510 TFLSSGTGTVRYPSEEVVLQYAADREQVNRLQRQLAGPEKPIKELKELMANYTGLDKIYEMVDQD 574
            :|....|..|.:|:.:.:|:.||:....:.......|.:|...||||:|..    |.:.::.:.:
Zfish   504 SFPEYSTQPVVFPAFDKILEKAAEIAGASDSMSMGRGGKKFYIELKEIMER----DPLSQLCENE 564

  Fly   575 RNAIWERRNDILRELPEELSILLHCVYWKERDDVADMWYLLKQWPLISIERSLELLDYAYPDPAV 639
            ::.||..|.|.....|:.|..||..|.|.:.:|:|.:..||:.||.:|...:|||||:.|||..|
Zfish   565 KDLIWTLRYDCRENFPQSLPKLLLSVKWSKHEDMAQLQALLQIWPKLSPRDALELLDFNYPDQYV 629

  Fly   640 RRFAIRCLHFLKDEDLLLYLLQLVQAIKHESYLESDLVVFLLERALRNQRIGHYFFWHLRSEMQT 704
            |.||:.||..:.|::||.|||||||.:::|.|.:..|..||||||..:::|||:.||||||||..
Zfish   630 REFAVSCLKDMSDDELLQYLLQLVQVLRYEPYYDCSLSRFLLERAQTSRKIGHFLFWHLRSEMYM 694

  Fly   705 PSMQTRFGLLLEVYLKGCKHHVAPLRKQLHVLEKLKQGSLIAKKGS-KEKVKTMLQDFLRDQRNS 768
            |::...|.|:||.|.:||..|:..|:||:..|.|||..:.:.|.|: |.|.|   |..|::...|
Zfish   695 PAVSVHFALILEAYCRGCIPHIEVLKKQVEALNKLKAVNELIKLGTIKTKTK---QAHLKEAMMS 756

  Fly   769 AVFQ--------NIQNPLNPSFRCSGVTPDRCKVMDSKMRPLWVVFENADVNASDVHIIFKNGDD 825
            .:.|        ::.:||||:...:||:.::||.|||||:|||:|:.|..:....|.||||||||
Zfish   757 CLRQTGFIETLSDLHSPLNPNILLAGVSVEKCKYMDSKMKPLWIVYNNKLLGGETVGIIFKNGDD 821

  Fly   826 LRQDMLTLQMLRVMDQLWKRDGMDFRMNIYNCISMEKSLGMIEVVRHAETIANIQKEKGMFSATS 890
            |||||||||:|::||.|||...:|.|:..|.|::.....|:||||..|:|||||||.....:|.:
Zfish   822 LRQDMLTLQILKLMDLLWKEANLDLRIVPYGCLATGDHSGLIEVVSSADTIANIQKTSSNMAAAA 886

  Fly   891 PFKKGSLLSWLKEHNKPADKLNKAINEFTLSCAGYCVATYVLGVADRHSDNIMVKRNGQLFHIDF 955
            .|.|.:||:|||:.|. .|.|:|||.|||||||||||||||||:.|||||||||:..||||||||
Zfish   887 AFNKDALLNWLKDKNS-GDALDKAIEEFTLSCAGYCVATYVLGIGDRHSDNIMVRSTGQLFHIDF 950

  Fly   956 GHILGHFKEKLGVRRERVPFVLTHDFVYVINKGFNDRESKEFCHFQELCERAFLVLRKHGCLILS 1020
            |||||:||.|.|::||||||:|||||::||.:| ....:::|.:|::.||.|:::|||:|.|.::
Zfish   951 GHILGNFKSKFGIKRERVPFILTHDFIHVIQEG-KTGNTEKFGNFRQYCEEAYMILRKNGNLFIT 1014

  Fly  1021 LFSMMISTGLPELSSEKDLDYLRETLVLDYTEEKAREHFRAKFSEALANSWKTSLNWASH 1080
            ||::|::.|||||:|.||:.||:::|.|..|:|:|.:.||.||.|||..||.|.:||.:|
Zfish  1015 LFALMLTAGLPELTSVKDIQYLKDSLALGKTDEEALKQFRQKFDEALRESWTTKVNWMAH 1074

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K92E	NP_001262770.1	PI3K_p85B	56..132	CDD:295322	21/76 (28%)
		PI3K_rbd	200..307	CDD:197540	34/114 (30%)
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	56/193 (29%)
		PI3Ka_I	552..723	CDD:238444	74/170 (44%)
		PI3Kc_I	727..1084	CDD:270709	186/362 (51%)
pik3cb	XP_005157523.1	PI3K_p85B	35..110	CDD:280372	21/77 (27%)
		PI3K_rbd	176..281	CDD:295323	33/106 (31%)
		C2_PI3K_class_I_beta_delta	334..511	CDD:176075	55/182 (30%)
		PI3Ka	548..713	CDD:294194	73/168 (43%)
		PKc_like	716..1077	CDD:304357	186/363 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579752
Domainoid	1	1.000	274	1.000	Domainoid score	I1738
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	716	1.000	Inparanoid score	I624
OMA	1	1.010	-	-		QHG57536
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	1	1.000	-	-		FOG0001201
OrthoInspector	1	1.000	-	-		otm25525
orthoMCL	1	0.900	-	-		OOG6_100986
Panther	1	1.100	-	-	O	PTHR10048
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X531
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.810