Protein Alignment CG15923 and TMEM67

DIOPT Version :10

• Sequence 1: NP_001262769.1
• Gene: CG15923 / 42443
• FlyBaseID: FBgn0038814
• Length: 984
• Species: Drosophila melanogaster
• Sequence 2: NP_714915.3
• Gene: TMEM67 / 91147
• HGNCID: 28396
• Length: 995
• Species: Homo sapiens
• Alignment Length: 1057
• Identity: 261/1057 - (24%)
• Similarity: 448/1057 - (42%)
• Gaps: 237/1057 - (22%)

  Fly    47 TFRFQNPTQCLKNEFYNLNLFDCVPCN---------------------EVAGGDGVQGKLQPDKF 90
            :|.||.|.:|..|::::::...||||.                     ...||..:..|..|:..
Human    40 SFPFQQPEKCDNNQYFDISALSCVPCGANQRQDARGTSCVCLPGFQMISNNGGPAIICKKCPENM 104

  Fly    91 ---------------------TCKCPAGHLSIYERG-----KTWPTCDEICTPDRS--------- 120
                                 .|.||.||: :.||.     .:..|| |:|..:.:
Human   105 KGVTEDGWNCISCPSDLTAEGKCHCPIGHI-LVERDINGTLLSQATC-ELCDGNENSFMVVNALG 167

  Fly   121 DNCTSVWLPQPRPTNQCSYRYLNSTAAFASQLPVHPLISGIILTHTN--PMSRAGDCHSCDMTHN 183
            |.|.           :|...::|::.:.|...| :.|..|:..:.|.  |:.|....
Human   168 DRCV-----------RCEPTFVNTSRSCACSEP-NILTGGLCFSSTGNFPLRRISAA-------- 212

  Fly   184 FRYQDFCLASTLLRPYVHYNAFWQATTTPDSSAPSRFGELKFVAFFCLTLRNDTACQQLANLCV- 247
             ||.:..::.|         :.|.|.....|:|.            |....|.|:||.|.|:||
Human   213 -RYGEVGMSLT---------SEWFAKYLQSSAAA------------CWVYANLTSCQALGNMCVM 255

  Fly   248 -LSHFSLEKHSPCSAFLLTQVSDVVMKYAHSGEQVRSLQPFLFY--KKGRATKELLSKTLQLP-- 307
             ::.:.......|..|.....:...:...||....|...|:|||  :.|.| .::||.| .||
Human   256 NMNSYDFATFDACGLFQFIFENTAGLSTVHSISFWRQNLPWLFYGDQLGLA-PQVLSST-SLPTN 318

  Fly   308 -------DRKELRLFSTTFGLDGGLKRWGAFHPEMLNMCQQKAPSLRVALPKRES-EVSCQLTLE 364
                   ...:|:..:.::.:.|...:|......:|.:|......|..|.....: :.:|::.:.
Human   319 FSFKGENQNTKLKFVAASYDIRGNFLKWQTLEGGVLQLCPDTETRLNAAYSFGTTYQQNCEIPIS 383

  Fly   365 R-LIDLANQRHNAEFLTVFLNFS--SNWQYLLHQLPVLIETLTPE----NQRPQQEEWQLVKRFQ 422
            : |||..    ...|..|:|.::  :..||:| .:|||...|...    ||.....:|.|.:|..
Human   384 KILIDFP----TPIFYDVYLEYTDENQHQYIL-AVPVLNLNLQHNKIFVNQDSNSGKWLLTRRIF 443

  Fly   423 LISA-SPRDSHLHQTMPRYEDAHKLQQYYSLRYVEDIEIRYTLDKDQPDRVG----LPLIRLRYR 482
            |:.| |.|::.| .|.||.           :|....|.:...|   .|:.:.    .|||.:.|.
Human   444 LVDAVSGRENDL-GTQPRV-----------IRVATQISLSVHL---VPNTINGNIYPPLITIAYS 493

  Fly   483 HIEMGSGNISLSQLYPFTLRISYDQVKRGWDWLILEVALPLLLLLAFAAAVFRLQNLRRRRKADL 547
            .|::...|   ||....:..::| ::..|...:..::||.:|..||..|::.:....:||..:.:
Human   494 DIDIKDAN---SQSVKVSFSVTY-EMDHGEAHVQTDIALGVLGGLAVLASLLKTAGWKRRIGSPM 554

  Fly   548 CQMSSLMEFLLQLAGNVAYALLATT-------LLLLLLQASNSRLLKI---------LLNTAFVL 596
            ..:.::::||:..||::|......|       |:....|.|.|.||.:         .:..||.|
Human   555 IDLQTVVKFLVYYAGDLANVFFIITVGTGLYWLIFFKAQKSVSVLLPMPIQEERFVTYVGCAFAL 619

  Fly   597 QFLFLGIHLWRSSQLELFLIDWERPR----SSCEGQRLNLDSSSLCSSVRTFVAESSVSAWRVLF 657
            :.|.....|.....:::|.||||||:    .:.||:          ..||:  |...||.||..|
Human   620 KALQFLHKLISQITIDVFFIDWERPKGKVLKAVEGE----------GGVRS--ATVPVSIWRTYF 672

  Fly   658 TANAWIRLSVTQKYSTLGQV-----FVVIAGYQFLERFTKG--------------DIFLRCCLIA 703
            .||.|..:...:|.::|.||     |:.:.|::.|......              ...||..:.|
Human   673 VANEWNEIQTVRKINSLFQVLTVLFFLEVVGFKNLALMDSSSSLSRNPPSYIAPYSCILRYAVSA 737

  Fly   704 AAYLLTYLLQI----IGHQLFIANPLQKFIDLCSLANISLFSLTEPGFGYYIHGRSPHGFADTDM 764
            |.:|...::|:    :.::.||.:.:::|:||||::|||:|.|:...|||||||||.||.|||:|
Human   738 ALWLAIGIIQVVFFAVFYERFIEDKIRQFVDLCSMSNISVFLLSHKCFGYYIHGRSVHGHADTNM 802

  Fly   765 SSMILQLQR-TQTMCGRRGLLMDSDKQAYVILPPRNLHIYLERLLLPFQRSLTGTLSQTMLYQKD 828
            ..|.:.|:| .:.:|.:|||:.::|.|.:.|.....:..:.:|            :.:|::.:..
Human   803 EEMNMNLKREAENLCSQRGLVPNTDGQTFEIAISNQMRQHYDR------------IHETLIRKNG 855

  Fly   829 ---IVPSIDGQMERTSIAYASVNRFFCAFIDHAIKDMDYIIKEKSFVEQLLNCEIDNYITENRGT 890
               ::.|.....|::..||..:|:|..:||||..|:|||.||:|..:|::|..|....:  .:..
Human   856 PARLLSSSASTFEQSIKAYHMMNKFLGSFIDHVHKEMDYFIKDKLLLERILGMEFMEPM--EKSI 918

  Fly   891 FYIDDSFSFSRVLLLGNHLHIFVLELLLVLSIFLMTSNLLIAAAGACALNILLRQVFRHWVR--- 952
            ||.|:.:|||.||..||...:.:.:||....:.|...|.::|:    .|..|.:::|| ::|
Human   919 FYNDEGYSFSSVLYYGNEATLLIFDLLFFCVVDLACQNFILAS----FLTYLQQEIFR-YIRNTV 978

  Fly   953 --RNISRKTLIDERFLL 967
              :|::.|||:|:|||:
Human   979 GQKNLASKTLVDQRFLI 995

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15923	NP_001262769.1	Meckelin	230..967	CDD:462892	217/814 (27%)
TMEM67	NP_714915.3	Cysteine-rich. /evidence=ECO:0000269|PubMed:34731008	37..280		54/283 (19%)
		Meckelin	167..995	CDD:462892	235/926 (25%)