DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pus1 and PUS1

DIOPT Version :9

Sequence 1:	NP_001163664.1	Gene:	Pus1 / 42440	FlyBaseID:	FBgn0038811	Length:	442	Species:	Drosophila melanogaster
Sequence 2:	NP_079491.2	Gene:	PUS1 / 80324	HGNCID:	15508	Length:	427	Species:	Homo sapiens

Alignment Length:	385	Identity:	172/385 - (44%)
Similarity:	238/385 - (61%)	Gaps:	32/385 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 WVDWKEQDEKDAANGVKRAPFDPADRIK--RKKSAILLSYCGANYYGMQRNPG---MQTIEEELF 132
            |.|.:...:|..:.|      |...|.|  ::|..:|::|.|..|:|||||.|   .:|||::|.
Human    59 WEDGEHPAKKLKSGG------DEERREKPPKRKIVLLMAYSGKGYHGMQRNVGSSQFKTIEDDLV 117

  Fly   133 KAMLKHKWITEDSFEQIQISCFQRAARTDKGVSAARQVCSVK--LPEELDLEAFNADLPQQIRLF 195
            .|:::...|.|:..|.::...|||.||||||||||.||.|:|  |.::: ||..|:.||..||:.
Human   118 SALVRSGCIPENHGEDMRKMSFQRCARTDKGVSAAGQVVSLKVWLIDDI-LEKINSHLPSHIRIL 181

  Fly   196 GVERVTKGFNAKDQCNARTYTYTLPTVAFAPFEEKVDDVHDTFRISPELLQKVKETLKLYEGTKN 260
            |::|||.|||:|::|:||||.|.|||.|||..:..|.|  :|:|:|.|.||:|...|..|:||.|
Human   182 GLKRVTGGFNSKNRCDARTYCYLLPTFAFAHKDRDVQD--ETYRLSAETLQQVNRLLACYKGTHN 244

  Fly   261 FHNFTSKKSFLDPSSKRFIMSFTSSEPFRSPQDIEFVTLKVKGQSFMLHQIRKMVGLAIAIVRGN 325
            ||||||:|...|||:.|:|:.....||| ..:.:||..::|||||||:|||||||||.:|||:|.
Human   245 FHNFTSQKGPQDPSACRYILEMYCEEPF-VREGLEFAVIRVKGQSFMMHQIRKMVGLVVAIVKGY 308

  Fly   326 TTAATLERALTEERLDLPMAPGLGLVLDTVHYERYNDRYGKDGIHNPLTWQAQEAQVQEFIEREI 390
            ...:.|||:...|::|:|.||||||||:.||:|:||.|:|.||:|.||.|..:|.:|..|.|..|
Human   309 APESVLERSWGTEKVDVPKAPGLGLVLERVHFEKYNQRFGNDGLHEPLDWAQEEGKVAAFKEEHI 373

  Fly   391 FSQIYKTEAEQRNMLDWIGTLHYHSYDTRTEDA-------PPP--SSEDKKVKGGDDDND 441
            :..|..||.::|:|..|:.||..|::......|       |.|  .||      ||.|.|
Human   374 YPTIIGTERDERSMAQWLSTLPIHNFSATALTAGGTGAKVPSPLEGSE------GDGDTD 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pus1	NP_001163664.1	TruA	102..362	CDD:223179	133/264 (50%)
Pus1	NP_001163664.1	PseudoU_synth_PUS1_PUS2	106..357	CDD:211335	129/255 (51%)
PUS1	NP_079491.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..83		7/29 (24%)
		TruA	84..363	CDD:223179	142/282 (50%)
		PseudoU_synth_PUS1_PUS2	88..340	CDD:211335	129/255 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	407..427		7/25 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147958
Domainoid	1	1.000	131	1.000	Domainoid score	I5185
eggNOG	1	0.900	-	-		E1_COG0101
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5931
Inparanoid	1	1.050	304	1.000	Inparanoid score	I2665
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54496
OrthoDB	1	1.010	-	-		D319574at33208
OrthoFinder	1	1.000	-	-		FOG0002248
OrthoInspector	1	1.000	-	-		oto91816
orthoMCL	1	0.900	-	-		OOG6_101974
Panther	1	1.100	-	-	LDO	PTHR11142
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4457
SonicParanoid	1	1.000	-	-		X1684
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800