DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pus1 and Pus1

DIOPT Version :9

Sequence 1:	NP_001163664.1	Gene:	Pus1 / 42440	FlyBaseID:	FBgn0038811	Length:	442	Species:	Drosophila melanogaster
Sequence 2:	NP_001020732.1	Gene:	Pus1 / 56361	MGIID:	1929237	Length:	441	Species:	Mus musculus

Alignment Length:	404	Identity:	172/404 - (42%)
Similarity:	247/404 - (61%)	Gaps:	46/404 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 RKKWVDWKEQDEKDAANGVKRA-PFDPADRIKRKKSAILLSYCGANYYGMQRNPG---MQTIEEE 130
            |..|| |:|.:.  .|..||.. ..:|..::.::|..:|::|.|..|:|||||.|   .:|||::
Mouse    50 RGGWV-WEETEH--PAKRVKGGEDEEPPRKLPKRKIVLLMAYSGKGYHGMQRNLGSSQFRTIEDD 111

  Fly   131 LFKAMLKHKWITEDSFEQIQISCFQRAARTDK------------------GVSAARQVCSVK--L 175
            |..|:::...|.|:....::...|||.|||||                  |||||.||.|:|  |
Mouse   112 LVSALVQAGCIPENHGTDMRKMSFQRCARTDKPLRTSACFCLYTGFLFHWGVSAAGQVVSLKVWL 176

  Fly   176 PEELDLEAFNADLPQQIRLFGVERVTKGFNAKDQCNARTYTYTLPTVAFAPFEEKVDDVHDTFRI 240
            .::: |:..|:.||..||:.|::|||.|||:|::|:||||.|.|||.|||..:..|.|  :::|:
Mouse   177 IDDI-LDKINSHLPSHIRILGLKRVTGGFNSKNKCDARTYCYMLPTFAFAHKDRDVQD--ESYRL 238

  Fly   241 SPELLQKVKETLKLYEGTKNFHNFTSKKSFLDPSSKRFIMSFTSSEPFRSPQDIEFVTLKVKGQS 305
            |.|.||:|...|..|:||.|||||||:|...:||::|:|:.....||| ..:.:||..:||||||
Mouse   239 SAETLQQVNRLLACYKGTHNFHNFTSQKGPREPSARRYILEMYCEEPF-VREGLEFAVIKVKGQS 302

  Fly   306 FMLHQIRKMVGLAIAIVRGNTTAATLERALTEERLDLPMAPGLGLVLDTVHYERYNDRYGKDGIH 370
            ||:|||||||||.:|||:|....:.|||:..||::|:|.||||||||:.||:|:||.|:|.||:|
Mouse   303 FMMHQIRKMVGLVVAIVKGYAPESVLERSWGEEKVDVPKAPGLGLVLERVHFEKYNQRFGGDGLH 367

  Fly   371 NPLTWQAQEAQVQEFIEREIFSQIYKTEAEQRNMLDWIGTLHYHSY--------DTRTEDAPPPS 427
            .||.|..:|.:|..|.|:.|:..|..||.::|:|..|:.||..|::        ||   .|..||
Mouse   368 EPLDWTQEEGKVTAFKEQYIYPTIVSTERDERSMAQWLNTLPIHNFSGTALGAADT---GAKVPS 429

  Fly   428 SEDKKVKGGDDDND 441
            |    ::|.:.|.|
Mouse   430 S----LEGSEGDGD 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pus1	NP_001163664.1	TruA	102..362	CDD:223179	131/282 (46%)
Pus1	NP_001163664.1	PseudoU_synth_PUS1_PUS2	106..357	CDD:211335	127/273 (47%)
Pus1	NP_001020732.1	TruA	80..377	CDD:223179	146/319 (46%)
Pus1	NP_001020732.1	PseudoU_synth_PUS1_PUS2	84..354	CDD:211335	137/292 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838045
Domainoid	1	1.000	129	1.000	Domainoid score	I5255
eggNOG	1	0.900	-	-		E1_COG0101
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5931
Inparanoid	1	1.050	306	1.000	Inparanoid score	I2609
Isobase	1	0.950	-	0	Normalized mean entropy	S2250
OMA	1	1.010	-	-		QHG54496
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002248
OrthoInspector	1	1.000	-	-		oto95394
orthoMCL	1	0.900	-	-		OOG6_101974
Panther	1	1.100	-	-	LDO	PTHR11142
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4457
SonicParanoid	1	1.000	-	-		X1684
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740