DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pus1 and pus2

DIOPT Version :9

Sequence 1:	NP_001163664.1	Gene:	Pus1 / 42440	FlyBaseID:	FBgn0038811	Length:	442	Species:	Drosophila melanogaster
Sequence 2:	NP_596485.1	Gene:	pus2 / 2541236	PomBaseID:	SPBC887.11	Length:	451	Species:	Schizosaccharomyces pombe

Alignment Length:	439	Identity:	105/439 - (23%)
Similarity:	182/439 - (41%)	Gaps:	104/439 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 KEQDEKDAANGVKRAPFDPADRIKRKKSA------ILLSYCGANYYGMQRNPGMQTIEEELFKAM 135
            |.|.|...|..::.......::|:..|.:      |||.|.|..|:|:|.|..::|||.::...:
pombe     8 KNQQEHIPAEDLETPKLPKREKIEGTKESNKVRIIILLGYSGYGYHGIQINNPLKTIEGDVVAVL 72

  Fly   136 LKHKWITEDSFEQIQISCFQRAARTDKGVSAARQVCSVKL--PEELDLEAFNADLPQ----QIRL 194
            .|..::..::.:...: |..|||||||||...|.:.|:.|  .:.||:.....:|.:    |||:
pombe    73 KKLGYLKTNNIDAEHL-CIARAARTDKGVHTLRNLISLNLFVDKPLDISLLKTELNEALCSQIRV 136

  Fly   195 FGVERVTKGFNAKDQCNARTYTYTLPTVAFAP--------------------------------- 226
            :.|....|.||.:..|.:|||.|.:|:.|..|
pombe   137 WSVFPAPKYFNPRISCESRTYEYLIPSFALLPPKPSCPLFKKMQKNLSRKLDNELERNLVYSMND 201

  Fly   227 ----------FEEKVDDVHDT-------------------------------------------- 237
                      .::::.::.||
pombe   202 LISFWNTVKLKQKEIQEMFDTNKDAFTNPFKGMFYEKPIPAGIVIPPQAKLKKALKQAEYYCYMN 266

  Fly   238 FRISPELLQKVKETLKLYEGTKNFHNFTSKKSFLDPSSKRFIMSFTSSEPFRSPQDIEFVTLKVK 302
            :||..:.|:.:::.||.|||..||||||.......||:.|||.|.|...|| ..::.|::.:.:|
pombe   267 YRIKEDRLKVLQQLLKKYEGRHNFHNFTVTDDSTSPSNYRFIESVTCGTPF-VYENWEWIPVTIK 330

  Fly   303 GQSFMLHQIRKMVGLAIAIVRGNTTAATLERALTEE-RLDLPMAPGLGLVLDTVHYERYNDRYGK 366
            |.||||:|||||:...:.|:|.......:::|.... .:::..:||..|:|..:.:..|||.. .
pombe   331 GNSFMLNQIRKMMAHVLMIIRSCAPTGLIDKAFDPNITMNISKSPGHVLLLKDIKFSSYNDSV-T 394

  Fly   367 DGIHNPLTWQAQEAQVQEFIEREIFSQIYKTEAEQRNMLDWIGTLHYHS 415
            ||:.. :.:...|..:.....:.|:..|.|.|.:::....::..:..|:
pombe   395 DGLEK-IQFDCFEEDILSLKIKTIYPDIIKLEQKEKLFFSFLSYIDQHT 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pus1	NP_001163664.1	TruA	102..362	CDD:223179	90/359 (25%)
Pus1	NP_001163664.1	PseudoU_synth_PUS1_PUS2	106..357	CDD:211335	88/344 (26%)
pus2	NP_596485.1	TruA	40..408	CDD:223179	94/371 (25%)
pus2	NP_596485.1	PseudoU_synth_PUS1_PUS2	43..386	CDD:211335	88/344 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	76	1.000	Domainoid score	I2447
eggNOG	1	0.900	-	-		E1_COG0101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54496
OrthoFinder	1	1.000	-	-		FOG0002248
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101974
Panther	1	1.100	-	-	O	PTHR11142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1684
TreeFam	1	0.960	-	-
	9	8.780