DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pus1 and pus1

DIOPT Version :9

Sequence 1:	NP_001163664.1	Gene:	Pus1 / 42440	FlyBaseID:	FBgn0038811	Length:	442	Species:	Drosophila melanogaster
Sequence 2:	NP_588446.1	Gene:	pus1 / 2539082	PomBaseID:	SPCC126.03	Length:	534	Species:	Schizosaccharomyces pombe

Alignment Length:	530	Identity:	142/530 - (26%)
Similarity:	212/530 - (40%)	Gaps:	164/530 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 KRTLKRKKWVDWKEQDEKDA----ANGVKRAPFDP-----ADRIKRKKSAILLSYCGANYYGMQR 120
            |||        |...|.::|    .|.:......|     .::..::|.|.|:.|||:.|:|||.
pombe     6 KRT--------WYNGDRREAKRNRPNSIYNGEGRPENLVVGEKKPKRKVACLVGYCGSGYHGMQL 62

  Fly   121 NPGMQTIEEELFKAMLKHKWITEDSFEQIQISCFQRAARTDKGVSAARQVCSVKL--PEELDLEA 183
            ||..:|||.:||.|.:|...::..:.:..:.....|||||||||.||..|.|:||  .:|..:|.
pombe    63 NPPSKTIEGDLFDAFVKAGAVSSYNADDPKKVALARAARTDKGVHAAGNVISLKLIMEDEKLIEK 127

  Fly   184 FNADLPQQIRLFGVERVTKGFNAKDQCNARTYTYTLPTVAFAP---------------------- 226
            .|..||..|||:.|.|....||.:..|.:|.|.|.:||.||.|
pombe   128 VNEHLPPSIRLWDVIRTINSFNPRTYCESRIYEYMVPTYAFVPPKPSSILGNCIMKNSPMPAEPI 192

  Fly   227 -------------FEE------------------------------------------------- 229
                         :||
pombe   193 NKENINQLSRSLFYEEGKEFWDDYDIAAKEILSLYEQDPEGFVNPYSKRGAAALANSENNKGSEA 257

  Fly   230 ----------------------KVDDVHD--------------------------TFRISPELLQ 246
                                  |.|.|.|                          .:|||.:.|.
pombe   258 GVSAKTNPDMDSDSSAIVNEFLKPDSVEDESAGSKIDPSYRLERALKHIEVLKLKNYRISADRLS 322

  Fly   247 KVKETLKLYEGTKNFHNFTSKKSFLDPSSKRFIMSFTSSEPFRSPQDIEFVTLKVKGQSFMLHQI 311
            .::|||..|.|..||||||..::|...:|.|.|.|||:|:||.. .|.|:::.||.|||||||||
pombe   323 VIRETLNQYVGVHNFHNFTVGQAFHQKNSNRVIRSFTASDPFMI-GDTEWISCKVHGQSFMLHQI 386

  Fly   312 RKMVGLAIAIVRGNTTAATLERALTEERLDLPMAPGLGLVLDTVHYERYNDRYGKDGIHNPLTWQ 376
            |||:.|||.:||.......::.|..:.::::|..||.||:|::..::.||:....:...:|:.:.
pombe   387 RKMIALAILVVRTGCPVERIQDAFKKTKINIPKGPGFGLLLESPFFKGYNEHKAPENNRDPIDFT 451

  Fly   377 AQEAQVQEFIEREIFSQIYKTEAEQR---NMLDWIGTLHYHSYDTR-------TEDAPPPSSEDK 431
            ..|.::..|....|:.:|:..||.::   ..|.:|.:  |:..|..       ||.....||:..
pombe   452 KYEQKITAFKHAHIYDKIFLEEARKQVFHCFLSFIDS--YNEEDFSYLSDIGITEKTQEVSSKLP 514

  Fly   432 KVKGGDDDND 441
            .|...|::.|
pombe   515 DVLSSDEEED 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pus1	NP_001163664.1	TruA	102..362	CDD:223179	115/393 (29%)
Pus1	NP_001163664.1	PseudoU_synth_PUS1_PUS2	106..357	CDD:211335	112/384 (29%)
pus1	NP_588446.1	TruA	44..454	CDD:223179	117/410 (29%)
		PseudoU_synth_PUS1_PUS2	48..432	CDD:211335	112/384 (29%)
		Glycosyltransferase_GTB_type	<404..>503	CDD:299143	20/100 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	93	1.000	Domainoid score	I1990
eggNOG	1	0.900	-	-		E1_COG0101
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5931
Inparanoid	1	1.050	225	1.000	Inparanoid score	I886
OMA	1	1.010	-	-		QHG54496
OrthoFinder	1	1.000	-	-		FOG0002248
OrthoInspector	1	1.000	-	-		otm47418
orthoMCL	1	0.900	-	-		OOG6_101974
Panther	1	1.100	-	-	LDO	PTHR11142
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4457
SonicParanoid	1	1.000	-	-		X1684
TreeFam	1	0.960	-	-
	14	13.860