DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pus1 and pus-1

DIOPT Version :9

Sequence 1:	NP_001163664.1	Gene:	Pus1 / 42440	FlyBaseID:	FBgn0038811	Length:	442	Species:	Drosophila melanogaster
Sequence 2:	NP_507242.1	Gene:	pus-1 / 180123	WormBaseID:	WBGene00004248	Length:	415	Species:	Caenorhabditis elegans

Alignment Length:	402	Identity:	155/402 - (38%)
Similarity:	223/402 - (55%)	Gaps:	57/402 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 KELEGEAVKDANRIKRTLKRKKWVDWKEQDEKDAANGVKRAPFDPADRIKRKKSAILLSYCGANY 115
            |.:|.:.|...|.::                   :.||.:.|..|  |:|:.|.|:||.|.|..|
Worm     3 KTVEEQTVDKLNHVQ-------------------SGGVHKEPKKP--RVKQAKYAMLLGYQGKKY 46

  Fly   116 YGMQRNPGMQTIEEELFKAMLKHKWITEDSFEQIQISCFQRAARTDKGVSAARQVCSVKLP-EEL 179
            ||||....:.|||.:|.:||....|||....|:.....||||||||:.||||||:|.::|| ::.
Worm    47 YGMQLQKDLPTIESKLLEAMETAGWITTAQKEKPFDFFFQRAARTDRAVSAARQMCGMQLPRDDA 111

  Fly   180 DLEA-----FNADLPQQIRLFGVERVTKGFNAKDQCNARTYTYTLPTVAFAPFEEKVDDVHDTFR 239
            ..:|     .|..||..||:||:.|.|..|:.:.||:.|||:||.|:..||   :..:..:.:||
Worm   112 KYQAEGAGILNNILPADIRVFGMRRTTNFFHPQKQCDHRTYSYTCPSFVFA---KPTELTNSSFR 173

  Fly   240 ISPELLQKVKETLKLYEGTKNFHNFTSKKSFLDPSSKRFIMSFTSSEPFR-----SPQDIEFVTL 299
            :|||.|.:|...|.:|.||.||.|:|:|:::.|.||.|:|:||...|||.     ..:|:|||.:
Worm   174 LSPETLAEVNSILSIYLGTHNFFNYTAKRAYDDMSSNRYIISFECKEPFLFRDDFRKEDVEFVQI 238

  Fly   300 KVKGQSFMLHQIRKMVGLAIAIVRGNTTAATLERALTEERLDLPMAPGLGLVLDTVHYERYNDRY 364
            .:|||||:|||||||||:.|.::|.....::::|:...:|:|:||||||||:|:..||:.|:.:.
Worm   239 VIKGQSFVLHQIRKMVGMVITVIRELHLKSSIQRSFEGQRMDIPMAPGLGLLLERTHYDSYDRKN 303

  Fly   365 GKDGIHNPLT-WQAQEAQVQEFIEREI----FSQIYK----TEAEQRNMLDWIGTLHYHSYDTRT 420
            .|.  |.||| |       .|.||:||    |..|.|    ||...:.||.|:..|.:|.:....
Worm   304 SKS--HEPLTDW-------GEIIEKEIERTKFELITKDMIETELLTQGMLKWLADLVHHDFTANA 359

  Fly   421 EDAPPPSSEDKK 432
            |...|    :||
Worm   360 EAEEP----EKK 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pus1	NP_001163664.1	TruA	102..362	CDD:223179	120/270 (44%)
Pus1	NP_001163664.1	PseudoU_synth_PUS1_PUS2	106..357	CDD:211335	115/261 (44%)
pus-1	NP_507242.1	PseudoU_synth_PUS1_PUS2	37..296	CDD:211335	115/261 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159908
Domainoid	1	1.000	121	1.000	Domainoid score	I3530
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5931
Inparanoid	1	1.050	251	1.000	Inparanoid score	I1998
Isobase	1	0.950	-	0	Normalized mean entropy	S2250
OMA	1	1.010	-	-		QHG54496
OrthoDB	1	1.010	-	-		D319574at33208
OrthoFinder	1	1.000	-	-		FOG0002248
OrthoInspector	1	1.000	-	-		oto20306
orthoMCL	1	0.900	-	-		OOG6_101974
Panther	1	1.100	-	-	LDO	PTHR11142
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4457
SonicParanoid	1	1.000	-	-		X1684
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.890