Protein Alignment Srp72 and SRP72

DIOPT Version :10

• Sequence 1: NP_650898.1
• Gene: Srp72 / 42439
• FlyBaseID: FBgn0038810
• Length: 650
• Species: Drosophila melanogaster
• Sequence 2: NP_015114.2
• Gene: SRP72 / 855891
• SGDID: S000006131
• Length: 640
• Species: Saccharomyces cerevisiae
• Alignment Length: 696
• Identity: 165/696 - (23%)
• Similarity: 285/696 - (40%)
• Gaps: 144/696 - (20%)

  Fly    24 NNQEFDKAVKAVNRILGVAPDDPTAL--HCKVVCLVQLSKFEEAYKFIEK-----NRLSSLF-FE 80
            :..|..:..:...::|....::|..:  .| :|.::|..|:::|..:::|     ::....| .|
Yeast    18 SQDEHSQVEQTCVKLLDSGCENPADVFRRC-LVAVIQQDKYQKALHYLKKFKHIDDKYGRKFALE 81

  Fly    81 KAYCEYQLNKQQQ------ALKTID-DAGLQPLPPNLK---ELRTQVLYRLERYDECLDSYRDII 135
            |.|..|:||...:      |:.|.| |..|:....:|:   .:|.|..|:...|.|....|:.:.
Yeast    82 KLYIFYKLNMPDEFNTLYTAIITDDLDTVLKKDIESLRGILHVRAQYCYKNGLYQEAFKIYQHLA 146

  Fly   136 KNTSDEYEEERRTNLS-------AVAANLAVDQTKEVPEVPEDTYEQYFNSACIQANRQKYAEAE 193
            .:  :|.:::.:..||       :||..| ::::..|..:.|.:|:..||.:.|.|:..||   :
Yeast   147 SH--NEKDQDSQIELSCNERVPLSVATEL-MNRSPLVTPMDESSYDLLFNESFIMASVGKY---D 205

  Fly   194 RKLRTSEKLCLEDECASEEEIIEEVDVIRVQLAYVLQLQGKTKEASSIYADCLRHKPKDAALVAV 258
            :.:...||..   :.|:.|....:::.|::||::|||:.|||.::..|....|:....|:....:
Yeast   206 KAIELLEKAL---QGATNEGYQNDINTIKLQLSFVLQMVGKTAQSKEILKGLLQELKADSPFSLI 267

  Fly   259 ASNNLVVVNKDQNVFDSKKKIRAALADACESRLTSRQKQVIALNNCLLALYTNAGDQVQQLSQKL 323
            ..|||       |.|....|...      ...|..|:..|..||...|..:|:......|.:...
Yeast   268 CQNNL-------NAFVDFSKYNT------NFNLLLRELNVEKLNTFNLQTFTHEQWSNIQRNVLF 319

  Fly   324 AQTYPQVEF---EALLIRCTQLAKDRKHKEAIEQ--LQKF-AAAHKSHEFVSKFAI--------- 373
            .:.:..|:.   |:||.|...     |:.:.::.  |:.: ..|.|.:...:|..:
Yeast   320 LRLFNNVKIHSQESLLSRTFD-----KYSKLVDNVTLESYKTQAKKLYHHTTKTILSGTDGSTIG 379

  Fly   374 -----IQLQLLQGNRKDAIETLLSLGE-----------AKYKPG---VVSALVSLYLGTDNKTAA 419
                 |||.:::...::||.    :||           .|:...   |...|..||.......:.
Yeast   380 ILLLTIQLLIIEKEWENAIR----IGELFLNESWKSSFEKFNDSQAIVCYILFELYKIKGRNNSK 440

  Fly   420 SALLKSAVDWYKKNEVS---SGDLSD---MWRQAA-EFHLRGGASETAASSLEELLKLNPNDTKV 477
            |.|||      |...|.   ||.:.:   .|:... |....|.|.|:.| .|.|:...:..|..|
Yeast   441 SVLLK------KLGSVRVQLSGKIQENIPFWKHVGFELLSMGNAKESKA-LLREISNFSKGDADV 498

  Fly   478 LAQLVIAYAQFQPKRALELSR--KLPKLETLTTASEIDALEAANWVMSAKAAKKTANTKVEPSPS 540
            |...|::.......:.::|.|  .:.||..|    .:..||:     |||.:|.||.:||:  ..
Yeast   499 LVDRVVSSDSLDIAQGIDLVRDIDIDKLIQL----GVKPLES-----SAKRSKNTAVSKVQ--KR 552

  Fly   541 TPLEKKKNRNRKRKGKLPKNYNAEVAPDPERWLPKYERTGFR--KKRGGARGKDVIKGSQGMASG 603
            ..||.||.|..||..|..:..:....||||||||..:|:.:|  ||:.||      |.:||   |
Yeast   553 KVLELKKKRKIKRLEKFLQGRDTSKLPDPERWLPLRDRSTYRPKKKQQGA------KQTQG---G 608

  Fly   604 AADQYDMSSRVNLTKNSPATPVYQETAPGPRQQHRKGGHKKKKGGR 649
            |.::          |:..|..:.::..|...::     .|.||.||
Yeast   609 AMNK----------KSEQALDISKKGKPTVNKK-----PKNKKKGR 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Srp72	NP_650898.1	Spy	36..>347	CDD:443119	77/338 (23%)
		TPR repeat	45..71	CDD:276809	6/27 (22%)
		SRP_TPR_like	52..155	CDD:435703	28/125 (22%)
		TPR repeat	75..101	CDD:276809	10/33 (30%)
		LapB	<321..515	CDD:442196	47/236 (20%)
		SRP72	534..579	CDD:462494	18/44 (41%)
SRP72	NP_015114.2	LapB	52..>256	CDD:442196	52/212 (25%)
		SRP72	<574..591	CDD:462494	8/16 (50%)