DRSC/TRiP Functional Genomics Resources

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Protein Alignment Srp72 and SRP72

DIOPT Version :10

Sequence 1:NP_650898.1 Gene:Srp72 / 42439 FlyBaseID:FBgn0038810 Length:650 Species:Drosophila melanogaster
Sequence 2:NP_008878.3 Gene:SRP72 / 6731 HGNCID:11303 Length:671 Species:Homo sapiens


Alignment Length:666 Identity:271/666 - (40%)
Similarity:407/666 - (61%) Gaps:36/666 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 IKAAYADVNKFGNNQEFDKAVKAVNRILGVAPDDPTALHCKVVCLVQLSKFEEAYKFIEKNRL-- 74
            :.|.:::||::|.|.:|.:|:|.||:||.:..||.||||||||||:|...|:||...|..:..  
Human    11 VPALWSEVNRYGQNGDFTRALKTVNKILQINKDDVTALHCKVVCLIQNGSFKEALNVINTHTKVL 75

  Fly    75 --SSLFFEKAYCEYQLNKQQQALKTIDDAGLQPLPPNLKELRTQVLYRLERYDECLDSYRDIIKN 137
              :||.||||||||:||:.:.|||||:.|..|  ...||||..|||||||||||||..|||:::|
Human    76 ANNSLSFEKAYCEYRLNRIENALKTIESANQQ--TDKLKELYGQVLYRLERYDECLAVYRDLVRN 138

  Fly   138 TSDEYEEERRTNLSAVAANLAVDQTKEVPE---VPEDTYEQYFNSACIQANRQKYAEAERKLRTS 199
            :.|:|:|||:||||||.|..: :..|.|||   :.|.|:|..:|:||....:.:..:|.:.|:.:
Human   139 SQDDYDEERKTNLSAVVAAQS-NWEKVVPENLGLQEGTHELCYNTACALIGQGQLNQAMKILQKA 202

  Fly   200 EKLC----LEDECASEEEIIEEVDVIRVQLAYVLQLQGKTKEASSIYADCLRHKPKDAALVAVAS 260
            |.||    .||...:||:...|:.:|..|:||:|||||:|:||..:|...::.||.|..|:||.:
Human   203 EDLCRRSLSEDTDGTEEDPQAELAIIHGQMAYILQLQGRTEEALQLYNQIIKLKPTDVGLLAVIA 267

  Fly   261 NNLVVVNKDQNVFDSKKKIRAALADACESRLTSRQKQVIALNNCLLALYTNAGDQVQQLSQKLAQ 325
            ||::.:||||||||||||::...|:..|.:|:.:|.|.|..|..|||:|||..:|.:::|..|..
Human   268 NNIITINKDQNVFDSKKKVKLTNAEGVEFKLSKKQLQAIEFNKALLAMYTNQAEQCRKISASLQS 332

  Fly   326 TYPQVEFEALLIRCTQLAKDRKHKEAIEQLQKFAAAHKSHEFVSKFAIIQLQLLQGNRKDAIETL 390
            ..|: ....:||:..||.::::|.:|||.||:|:..|..:....|..:.||::.|||...|...|
Human   333 QSPE-HLLPVLIQAAQLCREKQHTKAIELLQEFSDQHPENAAEIKLTMAQLKISQGNISKACLIL 396

  Fly   391 LSLGEAKYKPGVVSALVSLYLGTDNKTAASALLKSAVDWYKKNEVSSGDLSDMWRQAAEFHLRGG 455
            .|:.|.|:|||:|||||::|...::..:|..:...|:.||:.::..|.....:.|:||.|.|:.|
Human   397 RSIEELKHKPGMVSALVTMYSHEEDIDSAIEVFTQAIQWYQNHQPKSPAHLSLIREAANFKLKYG 461

  Fly   456 ASETAASSLEELLKLNPNDTKVLAQLVIAYAQFQPKRALELSRKLPKLETLTTASEIDALE--AA 518
            ..:.|.|.|::|.|.||.|...||||:.||:...|::|..||:.||..::::...:::|||  |.
Human   462 RKKEAISDLQQLWKQNPKDIHTLAQLISAYSLVDPEKAKALSKHLPSSDSMSLKVDVEALENSAG 526

  Fly   519 NWVMSAKAAKKTANTKVEPSPSTPLEKKKNRNRKRKGKLPKNYNAEVAPDPERWLPKYERTGFRK 583
            ...:..|..|.|.:::.:......|:|||   :|:||||||||:.:|.||||||||..||:.:|.
Human   527 ATYIRKKGGKVTGDSQPKEQGQGDLKKKK---KKKKGKLPKNYDPKVTPDPERWLPMRERSYYRG 588

  Fly   584 KRGGARGKDVIKGSQGMASGAADQYDMSSRVNLTKNSP-----AT----------PVYQETAPGP 633
            ::.|.:...:.||:||..:||:.:.|.|..|:....||     ||          |.:|:.|..|
Human   589 RKKGKKKDQIGKGTQGATAGASSELDASKTVSSPPTSPRPGSAATVSASTSNIIPPRHQKPAGAP 653

  Fly   634 RQQHRKGGHKKKKGGR 649
            ..: :|...||||||:
Human   654 ATK-KKQQQKKKKGGK 668

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Srp72NP_650898.1 Spy 36..>347 CDD:443119 146/321 (45%)
TPR repeat 45..71 CDD:276809 16/25 (64%)
SRP_TPR_like 52..155 CDD:435703 61/106 (58%)
TPR repeat 75..101 CDD:276809 17/25 (68%)
LapB <321..515 CDD:442196 65/193 (34%)
SRP72 534..579 CDD:462494 23/44 (52%)
SRP72NP_008878.3 Required for interaction with SRP68. /evidence=ECO:0000269|PubMed:16672232, ECO:0000269|PubMed:28369529 9..163 81/154 (53%)
LapB 21..322 CDD:442196 144/303 (48%)
TPR repeat 44..74 CDD:276809 16/29 (55%)
TPR repeat 79..104 CDD:276809 17/24 (71%)
TPR repeat 114..137 CDD:276809 17/22 (77%)
TPR repeat 176..204 CDD:276809 6/27 (22%)
LapB 180..502 CDD:442196 122/322 (38%)
TPR repeat 209..255 CDD:276809 18/45 (40%)
TPR 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339 226..259 15/32 (47%)
TPR repeat 371..404 CDD:276809 10/32 (31%)
Required for the interaction with the SRP68/7SL RNA complex. /evidence=ECO:0000250|UniProtKB:P33731 379..509 50/129 (39%)
TPR repeat 409..434 CDD:276809 8/24 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 532..671 53/141 (38%)
SRP72 532..584 CDD:462494 26/54 (48%)
RNA-binding. /evidence=ECO:0000269|PubMed:21073748 545..617 33/74 (45%)

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