DRSC/TRiP Functional Genomics Resources

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Protein Alignment Srp72 and Srp72

DIOPT Version :10

Sequence 1:NP_650898.1 Gene:Srp72 / 42439 FlyBaseID:FBgn0038810 Length:650 Species:Drosophila melanogaster
Sequence 2:NP_079967.1 Gene:Srp72 / 66661 MGIID:1333795 Length:671 Species:Mus musculus


Alignment Length:667 Identity:270/667 - (40%)
Similarity:407/667 - (61%) Gaps:38/667 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 IKAAYADVNKFGNNQEFDKAVKAVNRILGVAPDDPTALHCKVVCLVQLSKFEEAYKFIEKNRL-- 74
            :.|.:::||::|.|.:|.:|:|.||:||.:..||.||||||||||:|...|:||...|..:..  
Mouse    11 VPALWSEVNRYGQNSDFTRALKTVNKILQINKDDVTALHCKVVCLIQNGSFKEALNVINTHTKVL 75

  Fly    75 --SSLFFEKAYCEYQLNKQQQALKTIDDAGLQPLPPNLKELRTQVLYRLERYDECLDSYRDIIKN 137
              :||.||||||||:||:.:.|||||:.|..|  ...||||..|||||||||||||..|||:::|
Mouse    76 ANNSLSFEKAYCEYRLNRIENALKTIESATQQ--TDKLKELYGQVLYRLERYDECLAVYRDLVRN 138

  Fly   138 TSDEYEEERRTNLSAVAANLAVDQTKEVPE---VPEDTYEQYFNSACIQANRQKYAEAERKLRTS 199
            :.|:|:|||:||||||.|..: :..|.|||   :.|.|:|..:|:||....:.:..:|.:.|:.:
Mouse   139 SQDDYDEERKTNLSAVVAAQS-NWEKVVPENLGLQEGTHELCYNAACALIGQGQLTQAMKILQKA 202

  Fly   200 EKLC----LEDECASEEEIIEEVDVIRVQLAYVLQLQGKTKEASSIYADCLRHKPKDAALVAVAS 260
            |.||    .||...:||:...|:.:|..|:||::||||:|:||..:|...::.||.|.||:||.:
Mouse   203 EDLCRRSFSEDSDGAEEDPQAELAIIHGQMAYIMQLQGRTEEALQLYNQIIKLKPTDVALLAVIA 267

  Fly   261 NNLVVVNKDQNVFDSKKKIRAALADACESRLTSRQKQVIALNNCLLALYTNAGDQVQQLSQKLAQ 325
            ||::.:||||||||||||::...|:..|.:|:.||.|.|..|..|||:|||..:|.::::..|..
Mouse   268 NNIITINKDQNVFDSKKKVKLTNAEGVEFKLSKRQLQAIEFNKALLAMYTNQAEQCRKIAASLQS 332

  Fly   326 TYPQVEFEALLIRCTQLAKDRKHKEAIEQLQKFAAAHKSHEFVSKFAIIQLQLLQGNRKDAIETL 390
            ..|:. ...:||:..||.::::|.:|||.||:|:..|..:....|..:.||::.|||...|...|
Mouse   333 QSPEY-LLPVLIQAAQLCREKQHTKAIELLQEFSDQHPENAAEIKLTMAQLKISQGNISKACLIL 396

  Fly   391 LSLGEAKYKPGVVSALVSLYLGTDNKTAASALLKSAVDWYKKNEVSSGDLSDMWRQAAEFHLRGG 455
            .|:.|.::|||:|||||::|...::..:|..:...|:.||:.::..|.....:.|:||.|.|:.|
Mouse   397 RSIEELRHKPGMVSALVTMYSHEEDIDSAIEVFTQAIQWYQSHQPKSPAHLSLIREAANFKLKYG 461

  Fly   456 ASETAASSLEELLKLNPNDTKVLAQLVIAYAQFQPKRALELSRKLPKLETLTTASEIDALE---A 517
            ..:.|.|.||:|.|.|..|...||||:.||:...|::|..||:.||..::::...:::|||   .
Mouse   462 RKKEAVSDLEQLWKQNSKDIHTLAQLISAYSLVDPEKAKALSKHLPSSDSMSLKVDVEALENSPG 526

  Fly   518 ANWVMSAKAAKKTANTKVEPSPSTPLEKKKNRNRKRKGKLPKNYNAEVAPDPERWLPKYERTGFR 582
            |.::.. |..|.|.:.:.:......|:|||   :|:||||||||:.:|.||||||||..||:.:|
Mouse   527 ATYIRK-KGGKVTGDNQPKEQGQGDLKKKK---KKKKGKLPKNYDPKVTPDPERWLPMRERSYYR 587

  Fly   583 KKRGGARGKDVIKGSQGMASGAADQYDMSSRVNLTKNSP-----AT----------PVYQETAPG 632
            .::.|.:...:.||:||..:||:.:.|.|..|:....||     ||          |.:|:.|..
Mouse   588 GRKKGKKKDQIGKGTQGATAGASSELDASKAVSSPPTSPRPGSAATISSSASNIVPPRHQKPAGA 652

  Fly   633 PRQQHRKGGHKKKKGGR 649
            |..: :|...||||||:
Mouse   653 PATK-KKQQQKKKKGGK 668

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Srp72NP_650898.1 Spy 36..>347 CDD:443119 146/321 (45%)
TPR repeat 45..71 CDD:276809 16/25 (64%)
SRP_TPR_like 52..155 CDD:435703 61/106 (58%)
TPR repeat 75..101 CDD:276809 17/25 (68%)
LapB <321..515 CDD:442196 64/193 (33%)
SRP72 534..579 CDD:462494 23/44 (52%)
Srp72NP_079967.1 TPR repeat 44..74 CDD:276809 16/33 (48%)
SRP_TPR_like 51..154 CDD:435703 61/106 (58%)
TPR repeat 79..104 CDD:276809 15/24 (63%)
TPR repeat 176..204 CDD:276809 8/31 (26%)
LapB 180..473 CDD:442196 110/296 (37%)
TPR repeat 209..255 CDD:276809 19/45 (42%)
PPR repeat 341..367 CDD:276811 9/25 (36%)
PPR repeat 378..402 CDD:276811 10/23 (43%)
SRP72 532..584 CDD:462494 25/51 (49%)

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