Protein Alignment Srp72 and srpa-72

DIOPT Version :10

• Sequence 1: NP_650898.1
• Gene: Srp72 / 42439
• FlyBaseID: FBgn0038810
• Length: 650
• Species: Drosophila melanogaster
• Sequence 2: NP_494366.2
• Gene: srpa-72 / 173625
• WormBaseID: WBGene00017245
• Length: 635
• Species: Caenorhabditis elegans
• Alignment Length: 652
• Identity: 206/652 - (31%)
• Similarity: 336/652 - (51%)
• Gaps: 60/652 - (9%)

  Fly    18 DVNKFGNNQEFDKAVKAVNRILGVAPDDPTALHCKVVCLVQLSKFEEAYKFIEK---NRLSSLFF 79
            |:::...:.::.||:.:.|:::...|.:..|..||:|..:|||::.:|.:.|.|   :::..:.|
 Worm    15 DISRADTSGDYQKALTSANKLIRKYPKETFAFKCKLVAQIQLSQYADALELIRKTPAHQMGHVGF 79

  Fly    80 EKAYCEYQLNKQQQALK---TIDDAGLQPLPPNLKELRTQVLYRLERYDECLDSYRDIIKNTSDE 141
            ||||..|:.::..:|:|   |.|...::.|     ||:.||.|:.|.|.:..|.|..::||.||:
 Worm    80 EKAYIHYRQDELDEAIKELNTCDKDDVKAL-----ELKAQVFYKQENYQQAYDIYLYLLKNHSDD 139

  Fly   142 YEEERRTNLSAVAANLAVDQTKEVPEVPEDTYEQYFNSACIQANRQKYAEAERKLRTSEKLC--- 203
            .:|.||.|..||.|.|.....|:.....||:|.|.:|.||::...:|..:|...|..:.|.|
 Worm   140 SDELRRANFLAVQARLEAQGVKQAVAETEDSYSQLYNRACVEIEAEKLPQALESLEKALKTCRKS 204

  Fly   204 LEDECASEEEIIEEVDVIRVQLAYVLQLQGKTKEASSIYADCLRHKPKDAALVAVASNNLVVVNK 268
            .|||...|:||.||:|.||||.|||||..|:..||.:||.........|:::.|..:||:...:.
 Worm   205 FEDEDREEDEIEEELDSIRVQKAYVLQRMGQKAEALAIYEKVQAANHPDSSVKATITNNIPAASS 269

  Fly   269 DQNVFDSKKKIRAALADACESRLTSRQKQVIALNNCLLALYTNAGDQVQQLSQKLAQTYPQVEFE 333
            |..:.:|:|:.:||| ...:::||.||:..:.|||.|:.|.:|..:..::..::|...:...: :
 Worm   270 DFALPESRKRFKAAL-QIDQTKLTRRQRLTLMLNNALVLLLSNQREPCKRALEELVAKFGSSK-D 332

  Fly   334 ALLIRCTQLAKDRKHKEAIEQLQKFAAAHKSHEFVSKFAIIQLQLLQGNRKDAIETLLSLGEAKY 398
            ..||..|...|....:.|::.|       ...:.....|.:.:.|..|...:|:..:..| ....
 Worm   333 VALIEATLHFKMGDAEAALKVL-------AGSDLEQSLARLHVLLNAGRLPEAVGAIRDL-PISG 389

  Fly   399 KPGVVSALVSLYLGTDNKTAASALLKSAVDWYKKNEVSSG------DLSDMWRQAAEFHLRGGAS 457
            |.|..|.|.|..:..|::..|...|.:|..  .||:....      ||.::.:|      ||  :
 Worm   390 KLGASSLLTSTLIAADSRDEAVKELVAAST--AKNQTPEALKSILEDLVEVEQQ------RG--N 444

  Fly   458 ETAASS-LEELLKLNPNDTKVLAQLVIAYAQFQPKRALELSRKL-PKLETLTTASEIDALEAANW 520
            ||||:. ||:|::..|.|.::..:||.||::..||:|..||.|| |  ||:.....:|.||.::|
 Worm   445 ETAATKHLEKLVEKFPEDLQLQCRLVGAYSKTDPKKAESLSAKLFP--ETMEVDVNVDELEDSDW 507

  Fly   521 VMSAKAAKKTANTKVEPSPST-----PLEKKKNRNRKRKGKLPKNYNAEVAPDPERWLPKYERTG 580
            ::..:..::....|   ||.|     ..:.|....||||.:||||||:.|.||||||||:.||:.
 Worm   508 ILYGEKYRQKKEAK---SPQTAEIAATRKLKIATKRKRKIRLPKNYNSAVTPDPERWLPRQERST 569

  Fly   581 FRKKRGGARGKDVIKGSQGMASGAAD-QYDMSSRVNLTKNSPATPVYQETAPGPRQQHRKGGHKK 644
            :::||.. |.:::.:|:||.:|...: :|     |..:.||| .|:....|.|||||......:|
 Worm   570 YKRKRKN-REREIGRGTQGSSSANPNVEY-----VTASPNSP-RPLPGPVAEGPRQQRPNFQKQK 627

  Fly   645 KK 646
            ||
 Worm   628 KK 629

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Srp72	NP_650898.1	Spy	36..>347	CDD:443119	105/319 (33%)
		TPR repeat	45..71	CDD:276809	9/25 (36%)
		SRP_TPR_like	52..155	CDD:435703	38/108 (35%)
		TPR repeat	75..101	CDD:276809	10/28 (36%)
		LapB	<321..515	CDD:442196	52/201 (26%)
		SRP72	534..579	CDD:462494	25/49 (51%)
srpa-72	NP_494366.2	LapB	<23..199	CDD:442196	57/180 (32%)
		PEP_TPR_lipo	<60..480	CDD:274350	133/444 (30%)
		TPR repeat	105..166	CDD:276809	23/65 (35%)
		TPR repeat	171..199	CDD:276809	8/27 (30%)
		SRP72	516..568	CDD:462494	25/54 (46%)