Protein Alignment Srp72 and Srp72

DIOPT Version :10

• Sequence 1: NP_650898.1
• Gene: Srp72 / 42439
• FlyBaseID: FBgn0038810
• Length: 650
• Species: Drosophila melanogaster
• Sequence 2: XP_321122.5
• Gene: Srp72 / 1281184
• VectorBaseID: AGAMI1_009568
• Length: 696
• Species: Anopheles gambiae
• Alignment Length: 699
• Identity: 384/699 - (54%)
• Similarity: 494/699 - (70%)
• Gaps: 57/699 - (8%)

  Fly     1 MSKDANPKEALIKAAYADVNKFGNNQEFDKAVKAVNRILGVAPDDPTALHCKVVCLVQLSKFEEA 65
            ||| :..|||.|:..|.::||:.::.::|||:||.|:|:|:...:..|..||:.||:|..|||||
Mosquito     1 MSK-SETKEATIRQLYTELNKYCSSADYDKALKAANKIIGLDATEWKAAKCKLACLIQNGKFEEA 64

  Fly    66 YKFIEK-NRLSSLFFEKAYCEYQLNKQQQALKTIDDAGLQP-----------LPPNLKELRTQVL 118
            .||||: ..:....|||||.||:||:.:.|.:||.  .:.|           |.||||||..|:|
Mosquito    65 IKFIERGTSIPDTTFEKAYSEYRLNRAEDAFRTIQ--AVAPGGGGGADQWAGLAPNLKELLAQIL 127

  Fly   119 YRLERYDECLDSYRDIIKNTSDEYEEERRTNLSAVAANLAV------DQTKEVPEVPEDTYEQYF 177
            |||||:|||.:.||:|||||.|:|::|||||:||||||..:      .|:.....:||||||..:
Mosquito   128 YRLERFDECFELYRNIIKNTHDDYDDERRTNMSAVAANQCIVGSGGKQQSAAATNLPEDTYELTY 192

  Fly   178 NSACIQANRQKYAEAERKLRTSEKLC---LEDECASEEEIIEEVDVIRVQLAYVLQLQGKTKEAS 239
            |:||..|.|::|.|||||||||||:|   ||::.||||:||:|:.:|:|||||.||:||:.||||
Mosquito   193 NAACALAGRREYGEAERKLRTSEKMCRDSLEEDGASEEDIIDEITIIKVQLAYCLQMQGRVKEAS 257

  Fly   240 SIYADCLRHKPKDAALVAVASNNLVVVNKDQNVFDSKKKIRAALADACESRLTSRQKQVIALNNC 304
            ::|||.||||..|.||.||.||||||:|:|||||||:||::.|.::..:.:|||||::.||.|||
Mosquito   258 ALYADALRHKTNDVALTAVVSNNLVVINRDQNVFDSRKKMKVATSEQADQKLTSRQRKTIAFNNC 322

  Fly   305 LLALYTNAGDQVQQLSQKLAQTYPQVEFEALLIRCTQLAKDRKHKEAIEQLQKFA---AAHKSHE 366
            ||| |..:..:...|:.:||..:|.:||::||:|.:|||:|:|::||:|.|:.:|   .|.::.|
Mosquito   323 LLA-YFASPSECGLLASRLANAHPDLEFQSLLVRVSQLARDKKYREAVELLEAYAQRLPAGRTTE 386

  Fly   367 FVS-KFAIIQLQLLQGNRKDAIETLLSLGEAKYKPGVVSALVSLYLGTDNKTAASALLKSAVDWY 430
            .:. :|||:||||:.||||.|||||.|||||:|:||||||||:|:||.|||.|||.:|||||:||
Mosquito   387 LLQVRFAIVQLQLVAGNRKAAIETLESLGEARYQPGVVSALVTLHLGLDNKQAASEILKSAVEWY 451

  Fly   431 KKNE---VSSGDLSDMWRQAAEFHLRGGASETAASSLEELLKLNPNDTKVLAQLVIAYAQFQPKR 492
            |:.:   :|..||||||||||.||||||..||||.||||||:.:|||.|:|||||||||||.|||
Mosquito   452 KRQKSATISDSDLSDMWRQAASFHLRGGEPETAAKSLEELLRTHPNDMKLLAQLVIAYAQFDPKR 516

  Fly   493 ALELSRKLPKLETLTTASEIDALEAANWVMSAKAAKKTANTKV---------EPSPSTPLEK--- 545
            |.:.|::||.||||||.||||||||.||:|.|||.|:..|...         .|...||..:
Mosquito   517 AQQASKRLPALETLTTVSEIDALEATNWMMIAKAVKRKPNQPAGGGRTTGDQSPGAGTPSAEQQQ 581

  Fly   546 ---KKNRNRKRKGKLPKNYNAEVAPDPERWLPKYERTGFRKKRGGARGKDVIKGSQGMASGAADQ 607
               :|.:.:||||||||||...|.||||||||:|||||:|||| ..|.|::||||||.|||.|||
Mosquito   582 QAARKQKRKKRKGKLPKNYIIGVLPDPERWLPRYERTGYRKKR-DRRVKEIIKGSQGTASGQADQ 645

  Fly   608 YDMSSRVNLTKNSPATP----VYQ-----ETAPGPRQQHRKGGHKKKKG 647
            :|||...|.||||||||    |.|     ..|...||..||..||||||
Mosquito   646 FDMSKAYNQTKNSPATPGSGGVTQLEQNAAAAAATRQLPRKSQHKKKKG 694

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Srp72	NP_650898.1	Spy	36..>347	CDD:443119	172/331 (52%)
		TPR repeat	45..71	CDD:276809	14/25 (56%)
		SRP_TPR_like	52..155	CDD:435703	60/114 (53%)
		TPR repeat	75..101	CDD:276809	12/25 (48%)
		LapB	<321..515	CDD:442196	126/200 (63%)
		SRP72	534..579	CDD:462494	25/59 (42%)
Srp72	XP_321122.5	None