Protein Alignment Septin2 and SEPTIN8

DIOPT Version :10

• Sequence 1: NP_524417.1
• Gene: Septin2 / 42438
• FlyBaseID: FBgn0014029
• Length: 419
• Species: Drosophila melanogaster
• Sequence 2: NP_001092281.1
• Gene: SEPTIN8 / 23176
• HGNCID: 16511
• Length: 483
• Species: Homo sapiens
• Alignment Length: 426
• Identity: 283/426 - (66%)
• Similarity: 337/426 - (79%)
• Gaps: 9/426 - (2%)

  Fly     2 SVEVDFVDKKEVHLRTLKQSGHVGFDSLPDQLVNKSVQNGFVFNVMCIGETGLGKSTLMDTLFNT 66
            :.:::.....|...|:|...|||||||||||||:|||..||.||::|:||||:||||||:|||||
Human     3 ATDLERFSNAEPEPRSLSLGGHVGFDSLPDQLVSKSVTQGFSFNILCVGETGIGKSTLMNTLFNT 67

  Fly    67 SFESTPSPHTLPSVKLKAHTYELQESNVRLKLTICDTVGYGDQINKDDSFKAVVDYIDAQFENYL 131
            :||:..:.|....|:|:..||:||||||:|||||.|.||:|||||||:|::.:||||||||||||
Human    68 TFETEEASHHEACVRLRPQTYDLQESNVQLKLTIVDAVGFGDQINKDESYRPIVDYIDAQFENYL 132

  Fly   132 QEELKIKRSLVTCHDSRIHICLYFICPTGHGLKSLDLVCMKKLDSKVNIIPVIAKADTISKVELQ 196
            ||||||:|||...||:|||:|||||.||||.|||||||.||||||||||||:|||||||||.||.
Human   133 QEELKIRRSLFDYHDTRIHVCLYFITPTGHSLKSLDLVTMKKLDSKVNIIPIIAKADTISKSELH 197

  Fly   197 RFKAKIIQELNANGVHIYQFPTDDETVAETNTSMNSHIPFAVVGSTEFIKVGNKLIRARQYPWGT 261
            :||.||:.||.:|||.|||||||||.|||.|..||:|:|||||||||.:||||||:||||||||.
Human   198 KFKIKIMGELVSNGVQIYQFPTDDEAVAEINAVMNAHLPFAVVGSTEEVKVGNKLVRARQYPWGV 262

  Fly   262 VQVENETHCDFVKLREMLIRTNMEDMREKTHTRHYELYRQKRLEQMGFSDVDSDNKPISFQQTFE 326
            ||||||.|||||||||||||.||||:||:||:|||||||:.:||:|||.|.|.|::|.|.|:|:|
Human   263 VQVENENHCDFVKLREMLIRVNMEDLREQTHSRHYELYRRCKLEEMGFQDSDGDSQPFSLQETYE 327

  Fly   327 AKRSNHLAELQSKEEEVRQMFVQRVKEKEAELKESEKDLHAKFEKLKRDHAEEKRKLEESRKALE 391
            |||...|:|||.||||:|||||.:|||.|.||||.|::||.|||.|||.|.|||||:||.|:.||
Human   328 AKRKEFLSELQRKEEEMRQMFVNKVKETELELKEKERELHEKFEHLKRVHQEEKRKVEEKRRELE 392

  Fly   392 EDYLDFQRRKQQL---------ATAHHTLTLGKSKK 418
            |:...|.|||..:         ||:...|...|.||
Human   393 EETNAFNRRKAAVEALQSQALHATSQQPLRKDKDKK 428

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Septin2	NP_524417.1	CDC_Septin	40..308	CDD:206649	198/267 (74%)
		PTZ00121	<285..393	CDD:173412	70/107 (65%)
SEPTIN8	NP_001092281.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..22		3/18 (17%)
		CDC_Septin	41..309	CDD:206649	198/267 (74%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01056	51..58		5/6 (83%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01056	103..106		1/2 (50%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01056	186..189		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	411..443		6/18 (33%)