DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5412 and OVCA2

DIOPT Version :9

Sequence 1:	NP_650895.1	Gene:	CG5412 / 42434	FlyBaseID:	FBgn0038806	Length:	279	Species:	Drosophila melanogaster
Sequence 2:	NP_543012.1	Gene:	OVCA2 / 124641	HGNCID:	24203	Length:	227	Species:	Homo sapiens

Alignment Length:	225	Identity:	81/225 - (36%)
Similarity:	118/225 - (52%)	Gaps:	16/225 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 VRVLCLHGYRQNGEAFKNKLGSFRKFANKYAEFVFITAPHV---------AKALESAAEPVPEQR 86
            :|||||.|:||:...|:.|.|:.||.....||.|.::.||.         |::...:..|..:.|
Human     7 LRVLCLAGFRQSERGFREKTGALRKALRGRAELVCLSGPHPVPDPPGPEGARSDFGSCPPEEQPR 71

  Fly    87 SWWANKDDGS-FKGTNKGGPAFGFQESLRCVEEAWRTQGPFQGLLGFSQGACFVGLICGLAKKKL 150
            .||.::.:.. |....:.....|.:|||..|.:|....|||.|||||||||....|:|.|.:...
Human    72 GWWFSEQEADVFSALEEPAVCRGLEESLGMVAQALNRLGPFDGLLGFSQGAALAALVCALGQAGD 136

  Fly   151 TSI-RPEFAVLASGFL-SGSLVHMSAYEEAISIPTLHIYGQTDEIIPKEMSESLAARFKNAEVLE 213
            ... .|.|.:|.|||. .|.....|..:..:|:|:||::|.||::||.:.|..||::|..|..|.
Human   137 PRFPLPRFILLVSGFCPRGIGFKESILQRPLSLPSLHVFGDTDKVIPSQESVQLASQFPGAITLT 201

  Fly   214 HSGGHYFPATAQQKQTFINFFQDRLQEYLE 243
            |||||:.||.|.|:|.::.|    |.::.|
Human   202 HSGGHFIPAAAPQRQAYLKF----LDQFAE 227

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5412	NP_650895.1	FSH1	28..230	CDD:281892	78/210 (37%)
CG5412	NP_650895.1	MhpC	<177..244	CDD:223669	28/67 (42%)
OVCA2	NP_543012.1	FSH1	5..218	CDD:309182	78/210 (37%)
OVCA2	NP_543012.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	44..68		4/23 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151374
Domainoid	1	1.000	137	1.000	Domainoid score	I4912
eggNOG	1	0.900	-	-		E1_KOG2551
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6086
Inparanoid	1	1.050	141	1.000	Inparanoid score	I4492
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53056
OrthoDB	1	1.010	-	-		D1190789at2759
OrthoFinder	1	1.000	-	-		FOG0002782
OrthoInspector	1	1.000	-	-		oto89021
orthoMCL	1	0.900	-	-		OOG6_102370
Panther	1	1.100	-	-	LDO	PTHR48070
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R361
SonicParanoid	1	1.000	-	-		X2182
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800