DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TFAM and TOX

DIOPT Version :9

Sequence 1:	NP_732527.1	Gene:	TFAM / 42433	FlyBaseID:	FBgn0038805	Length:	284	Species:	Drosophila melanogaster
Sequence 2:	NP_055544.1	Gene:	TOX / 9760	HGNCID:	18988	Length:	526	Species:	Homo sapiens

Alignment Length:	139	Identity:	32/139 - (23%)
Similarity:	64/139 - (46%)	Gaps:	15/139 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 DPSRANDTDHRPLTPPRPLAAASISNTPAVPSKTLEEQLGLPPRPKKPLTPYFRFMREQRPKLKA 98
            |.|:.|..:.||        |:.:...|..|.|..::.   |..|:||::.|..|.|:.:..:|.
Human   228 DTSKINGGEKRP--------ASDMGKKPKTPKKKKKKD---PNEPQKPVSAYALFFRDTQAAIKG 281

  Fly    99 ANPQITTVEVVRQLSKNWSDADAQLKERLQAEFKRDQQIYVEERTKYDATLTEEQRAEIKQLK-- 161
            .||..|..||.:.::..|.....:.|:..:.:.:..::.|:::...|.|:|..:..:|...:|
Human   282 QNPNATFGEVSKIVASMWDGLGEEQKQVYKKKTEAAKKEYLKQLAAYRASLVSKSYSEPVDVKTS 346

  Fly   162 --QDLVDAK 168
              ..|:::|
Human   347 QPPQLINSK 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TFAM	NP_732527.1	HMGB-UBF_HMG-box	78..142	CDD:238686	15/63 (24%)
TFAM	NP_732527.1	HMGB-UBF_HMG-box	183..247	CDD:238686
TOX	NP_055544.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	138..178
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	192..264		11/46 (24%)
		Nuclear localization signal. /evidence=ECO:0000255	237..256		6/26 (23%)
		NHP6B	<257..>360	CDD:227935	23/102 (23%)
		HMG-box	261..>310	CDD:238037	14/48 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5648
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810