DRSC/TRiP Functional Genomics Resources

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Protein Alignment TFAM and Hmgb2

DIOPT Version :9

Sequence 1:NP_732527.1 Gene:TFAM / 42433 FlyBaseID:FBgn0038805 Length:284 Species:Drosophila melanogaster
Sequence 2:NP_001350372.1 Gene:Hmgb2 / 97165 MGIID:96157 Length:210 Species:Mus musculus


Alignment Length:194 Identity:48/194 - (24%)
Similarity:77/194 - (39%) Gaps:46/194 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    73 GLPPRPKKPLTPYFRFMREQRPKLKAANP--QITTVEVVRQLSKNWSDADAQLKERLQAEFKRDQ 135
            |.|.:|:..::.|..|::..|.:.|..:|  .:...|..::.|:.|....|:.|.:.:...|.|:
Mouse     4 GDPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDLAKSDK 68

  Fly   136 QIYVEERTKYDATLTEEQRAEIKQLKQDLVDAKERRQLRKRVKELGRPKKPASAFLRFIASER-- 198
            ..|..|...|                   |..|..::.:|  |:...||:|.|||..|.:..|  
Mouse    69 ARYDREMKNY-------------------VPPKGDKKGKK--KDPNAPKRPPSAFFLFCSENRPK 112

  Fly   199 --INTPQ---GDKQTYREWHQKTTAK-----WTRLSDSEKEVYMQESRKEMELYRKAISVWEEK 252
              |..|.   ||           |||     |:..|..:|:.|.|::.|..|.|.|.|:.:..|
Mouse   113 IKIEHPGLSIGD-----------TAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAK 165

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TFAMNP_732527.1 HMGB-UBF_HMG-box 78..142 CDD:238686 14/65 (22%)
HMGB-UBF_HMG-box 183..247 CDD:238686 24/75 (32%)
Hmgb2NP_001350372.1 HMG-box 7..78 CDD:320749 15/70 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 71..102 11/51 (22%)
HMG_box 95..162 CDD:278906 25/77 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 162..210 1/4 (25%)
Required for chemotactic activity. /evidence=ECO:0000250|UniProtKB:P26583 165..180 1/1 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5648
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1641977at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR48112
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.920

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