DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TFAM and IXR1

DIOPT Version :9

Sequence 1:	NP_732527.1	Gene:	TFAM / 42433	FlyBaseID:	FBgn0038805	Length:	284	Species:	Drosophila melanogaster
Sequence 2:	NP_012893.3	Gene:	IXR1 / 853836	SGDID:	S000001515	Length:	597	Species:	Saccharomyces cerevisiae

Alignment Length:	221	Identity:	52/221 - (23%)
Similarity:	98/221 - (44%)	Gaps:	45/221 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 DPSRANDTDHRPLTPPRPLAAASISNTPAVPSKTLEEQLGLPPRPKKPLTPYFRFMREQRPKLKA 98
            |||.|.:             ||..:||...|..       |||..:..||.:.:.|::|
Yeast   256 DPSSAGN-------------AAGNANTATHPGL-------LPPNLQPQLTHHQQQMQQQ------ 294

  Fly    99 ANPQITTVEVVRQLSKNWSDADAQLKERLQAEFKRDQQIYVEERTKYDATLTEEQRAEIKQLKQD 163
                 ..::..:||         |.:::||.:.:..||..::::..:   |.::|:.:...:.:.
Yeast   295 -----LQLQQQQQL---------QQQQQLQQQHQLQQQQQLQQQHHH---LQQQQQQQQHPVVKK 342

  Fly   164 LVDAKERRQLRKRVKELGRPKKPASAFLRFIASERIN-TPQGDKQTYREWHQKTTAKWTRLSDSE 227
            |...:.|.:.||::|:.| ||:|:||:..|..|.|.. ..|..:....|..:..:|:|..|:|.:
Yeast   343 LSSTQSRIERRKQLKKQG-PKRPSSAYFLFSMSIRNELLQQFPEAKVPELSKLASARWKELTDDQ 406

  Fly   228 KEVYMQESRKEMELYRKAISVWEEKM 253
            |:.:.:|.|...|.||.....:|:.:
Yeast   407 KKPFYEEFRTNWEKYRVVRDAYEKTL 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TFAM	NP_732527.1	HMGB-UBF_HMG-box	78..142	CDD:238686	11/63 (17%)
TFAM	NP_732527.1	HMGB-UBF_HMG-box	183..247	CDD:238686	20/64 (31%)
IXR1	NP_012893.3	NHP6B	<338..501	CDD:227935	27/96 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5648
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48112
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910