DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TFAM and Hmgb4

DIOPT Version :9

Sequence 1:	NP_732527.1	Gene:	TFAM / 42433	FlyBaseID:	FBgn0038805	Length:	284	Species:	Drosophila melanogaster
Sequence 2:	NP_081312.2	Gene:	Hmgb4 / 69317	MGIID:	1916567	Length:	181	Species:	Mus musculus

Alignment Length:	189	Identity:	51/189 - (26%)
Similarity:	78/189 - (41%)	Gaps:	45/189 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 EEQLGLPPRPKKPLTPYFRFMREQRPKLKAANPQ--ITTVEVVRQLSKNWSDADAQLKERLQAEF 131
            ::||    |||..::.|..||...|.|.|...|.  :...|..|:.|:.|
Mouse     4 KDQL----RPKVNVSSYIHFMLNFRNKFKEQQPNTYLGFKEFSRKCSEKW--------------- 49

  Fly   132 KRDQQIYVEERTKYDATLTEEQRAEIKQLKQDLVDAKERRQLRKRVKELGRPKKPASAFLRFIAS 196
               :.|...|:.||:| |.|..:|..:|...:.:.  :||:.|||  :...|:||.|:||.|...
Mouse    50 ---RSISKHEKAKYEA-LAELDKARYQQEMMNYIG--KRRKRRKR--DPKAPRKPPSSFLLFSRD 106

  Fly   197 ERINTPQGDKQTYREWHQKTTAK-----WTRLSDSEKEVYMQESR-------KEMELYR 243
            .....    ||...:|.....||     |:...::||:.|.|::.       :|.|.||
Mouse   107 HYAML----KQENPDWTVVQVAKAAGKMWSTTDEAEKKPYEQKAALMRAKYFEEQEAYR 161

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TFAM	NP_732527.1	HMGB-UBF_HMG-box	78..142	CDD:238686	14/65 (22%)
TFAM	NP_732527.1	HMGB-UBF_HMG-box	183..247	CDD:238686	21/73 (29%)
Hmgb4	NP_081312.2	HMG-box	8..78	CDD:294061	23/88 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	80..100		9/23 (39%)
		HMG-box	93..156	CDD:238037	17/66 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5648
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1641977at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48112
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010