DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TFAM and tfam

DIOPT Version :9

Sequence 1:	NP_732527.1	Gene:	TFAM / 42433	FlyBaseID:	FBgn0038805	Length:	284	Species:	Drosophila melanogaster
Sequence 2:	NP_001070857.1	Gene:	tfam / 571106	ZFINID:	ZDB-GENE-061013-552	Length:	277	Species:	Danio rerio

Alignment Length:	213	Identity:	61/213 - (28%)
Similarity:	110/213 - (51%)	Gaps:	17/213 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 PKKPLTPYFRFMREQRPKLKAANPQITTVEVVRQLSKNWSDADAQLKERLQA---EFKRDQQIYV 139
            ||:|||.|..|:::.:|.:...||.|.:|:|:|::::.|.....:.|:..|.   |.|...::.:
Zfish    47 PKRPLTAYMTFVKDMQPTVSKQNPSIKSVDVMRKIAQQWKMLTTEQKQPFQVASLEAKEQYKLAL 111

  Fly   140 EERTKYDATLTEEQRAEIKQLKQDLVDAKERRQLRKRVKELGRPKKPASAFLRFIASERI----N 200
            |   |:.|.||..:.|...:.|:..|..::..:.:|.:..||:||:|.|.|..|:|...:    .
Zfish   112 E---KFKAQLTPAESAAFAEEKRQRVAKRKAIRKKKELNNLGKPKRPRSTFNIFMAEHFVEAKGT 173

  Fly   201 TPQGDKQTYREWHQKTTAKWTRLSDSEKEVYMQESRKEMELYRKAISVWEEKMIRLGHIDVVRHG 265
            |.|...::.|:       .|.||||::|::|:|.:..:...|:..|..|||.|:.:|..|::|..
Zfish   174 TTQAKLKSLRD-------DWNRLSDTQKQMYIQLAEDDKVRYKNEIKSWEEHMMEIGREDLLRRK 231

  Fly   266 NLIDPPEPKPRKTLASKD 283
            ...........||:|:|:
Zfish   232 TKSALKAKAKTKTIATKN 249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TFAM	NP_732527.1	HMGB-UBF_HMG-box	78..142	CDD:238686	20/66 (30%)
TFAM	NP_732527.1	HMGB-UBF_HMG-box	183..247	CDD:238686	19/67 (28%)
tfam	NP_001070857.1	HMG_box	47..114	CDD:278906	20/69 (29%)
tfam	NP_001070857.1	HMGB-UBF_HMG-box	152..213	CDD:238686	19/67 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5648
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31139
Inparanoid	1	1.050	105	1.000	Inparanoid score	I4922
OMA	1	1.010	-	-		QHG49431
OrthoDB	1	1.010	-	-		D1641977at2759
OrthoFinder	1	1.000	-	-		FOG0007031
OrthoInspector	1	1.000	-	-		oto38861
orthoMCL	1	0.900	-	-		OOG6_107571
Panther	1	1.100	-	-	O	PTHR48112
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R14311
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.870