DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TFAM and BBX

DIOPT Version :9

Sequence 1:	NP_732527.1	Gene:	TFAM / 42433	FlyBaseID:	FBgn0038805	Length:	284	Species:	Drosophila melanogaster
Sequence 2:	XP_024309412.1	Gene:	BBX / 56987	HGNCID:	14422	Length:	953	Species:	Homo sapiens

Alignment Length:	316	Identity:	64/316 - (20%)
Similarity:	105/316 - (33%)	Gaps:	77/316 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 KDWP-PSDPSRANDTDHRPLTPPRP-------------------LAAASISNTPAVPSKTLEEQL 72
            |.|. |||.||...:..:..|...|                   ||......||.|.|.|....:
Human   181 KLWAFPSDSSRDLPSPKKAKTEEMPQLNFGMADPTQMGGLSMLLLAGEHALGTPEVSSGTCRPDV 245

  Fly    73 GLPP--RPKKPLTPYFRFMR--------------------EQRPKLKAANPQITTVEVVRQLSKN 115
            ...|  |.|.||   |:|..                    .|..::.:...|:...|.|::..|:
Human   246 SESPELRQKSPL---FQFAEISSSTSHSDASTKQCQTSALFQFAEISSNTSQLGGAEPVKRCGKS 307

  Fly   116 WSDADAQLKERLQAE--FKRDQQIYVEERTKYDATLTE----EQRAEIKQLKQDLVDAKERRQLR 174
               |..||.|...|.  .|.::...::.:......:.|    ::..|||..|.|....::..:..
Human   308 ---ALFQLAEMCLASEGMKMEESKLIKAKESDGGRIKELEKGKEEKEIKMEKTDETRLQKEAEFE 369

  Fly   175 KRVKELGRPKKPASAFLRFIASERINTPQGDKQTYREWHQKTTAKWTRLSD----SEKEVYMQE- 234
            |..||..|..|....|......:.:.....|.:..|:...:...|.:...|    :..::.:.:
Human   370 KSAKENLRDSKELRNFEALQIDDIMAIKMEDPKEIRKEELEEDHKCSHFPDFSYSASSKIIISDV 434

  Fly   235 -SRKEMELYRKAISVWEE-----------KMIRLGHIDVVRHGNLIDPPEPKPRKT 278
             |||:...:...|.:.|:           |..:...:|  ||||    .:..|:||
Human   435 PSRKDHMCHPHGIMIIEDPAALNKPEKLKKKKKKSKMD--RHGN----DKSTPKKT 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TFAM	NP_732527.1	HMGB-UBF_HMG-box	78..142	CDD:238686	16/85 (19%)
TFAM	NP_732527.1	HMGB-UBF_HMG-box	183..247	CDD:238686	9/69 (13%)
BBX	XP_024309412.1	SOX-TCF_HMG-box	91..162	CDD:238684
BBX	XP_024309412.1	DUF2028	203..>335	CDD:312980	26/137 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1641977at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010