Protein Alignment TFAM and HMGB1

DIOPT Version :10

• Sequence 1: NP_732527.1
• Gene: TFAM / 42433
• FlyBaseID: FBgn0038805
• Length: 284
• Species: Drosophila melanogaster
• Sequence 2: NP_002119.1
• Gene: HMGB1 / 3146
• HGNCID: 4983
• Length: 215
• Species: Homo sapiens
• Alignment Length: 214
• Identity: 46/214 - (21%)
• Similarity: 82/214 - (38%)
• Gaps: 41/214 - (19%)

  Fly    73 GLPPRPKKPLTPYFRFMREQRPKLKAANP--QITTVEVVRQLSKNWSDADAQLKERLQAEFKRDQ 135
            |.|.:|:..::.|..|::..|.:.|..:|  .:...|..::.|:.|....|:.|.:.:...|.|:
Human     4 GDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADK 68

  Fly   136 QIYVEERTKYDATLTEEQRAEIKQLKQDLVDAKERRQLRKRVKELGRPKKPASAFLRF------- 193
            ..|..|...|                     ...:.:.:|:.|:...||:|.|||..|
Human    69 ARYEREMKTY---------------------IPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPK 112

  Fly   194 IASERINTPQGDKQTYREWHQKTTAKWTRLSDSEKEVYMQESRKEMELYRKAISVWEEKMIRLGH 258
            |..|......||..      :|....|...:..:|:.|.:::.|..|.|.|.|:.:..|    |.
Human   113 IKGEHPGLSIGDVA------KKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAK----GK 167

  Fly   259 IDVVRHGNLIDPPEPKPRK 277
            .|..:.| ::...:.|.:|
Human   168 PDAAKKG-VVKAEKSKKKK 185

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TFAM	NP_732527.1	HMG-box_SF	78..138	CDD:469606	13/61 (21%)
		HMG-box_SF	168..263	CDD:469606	25/101 (25%)
HMGB1	NP_002119.1	Sufficient for interaction with HAVCR2. /evidence=ECO:0000250|UniProtKB:P63158	1..97		21/113 (19%)
		LPS binding (delipidated). /evidence=ECO:0000269|PubMed:21660935	3..15		3/10 (30%)
		HMG-box_HMGB_rpt1	8..76	CDD:438794	15/67 (22%)
		Nuclear localization signal (NLS) 1. /evidence=ECO:0000250|UniProtKB:P63159	27..43		3/15 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	76..95		3/39 (8%)
		LPS binding (Lipid A). /evidence=ECO:0000269|PubMed:21660935	80..96		2/15 (13%)
		Cytokine-stimulating activity. /evidence=ECO:0000269|PubMed:12765338	89..108		8/18 (44%)
		HMG-box_HMGB_rpt2	93..163	CDD:438795	20/75 (27%)
		Binding to AGER/RAGE. /evidence=ECO:0000250|UniProtKB:P63159	150..183		9/37 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	161..215		6/30 (20%)
		Nuclear localization signal (NLS) 2. /evidence=ECO:0000250|UniProtKB:P63159	178..184		1/5 (20%)