DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TFAM and Tox4

DIOPT Version :9

Sequence 1:	NP_732527.1	Gene:	TFAM / 42433	FlyBaseID:	FBgn0038805	Length:	284	Species:	Drosophila melanogaster
Sequence 2:	NP_775446.2	Gene:	Tox4 / 286990	RGDID:	708449	Length:	619	Species:	Rattus norvegicus

Alignment Length:	308	Identity:	61/308 - (19%)
Similarity:	102/308 - (33%)	Gaps:	108/308 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TTTLMSSRGGLI-GSLINKVRQVVAKDWPPSDPSRANDTDHR---------PLTPPRPLAAASI- 57
            |..||...|||: |.|                   ..|.||.         |:|...|:...:.
  Rat    89 THGLMEQGGGLLSGGL-------------------TMDLDHSIGTQYSANPPVTIDVPMTDMTSG 134

  Fly    58 ----SNTPAVPSKTLEEQLG--------LPPRPKKPLTPYFRFMREQRPKLKAANPQITTVEVVR 110
                |....:....|..|||        |||              .|.|:.:.:    ||.....
  Rat   135 LMGHSQLTTIDQSELSSQLGLSLGGGTILPP--------------AQSPEDRLS----TTPSPTN 181

  Fly   111 QLSKNWSDADAQLKERLQAEFKRD---QQIYVEERTKYDATLTEEQRAEIKQLKQDLVDAKERRQ 172
            .|.::..|           :|:|.   |:..|.|..|                       |::..
  Rat   182 SLHEDGVD-----------DFRRQLPAQKTVVVETGK-----------------------KQKAP 212

  Fly   173 LRKRVKELGRPKKPASAF-LRFIASERINTPQGDKQTYREWHQKTTAKWTRLSDSEKEVYMQESR 236
            .:::.|:...|:||.||: |.|..::.....|....|:.|..:...:.|..|.:.:|:||.:::.
  Rat   213 KKRKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDSLGEEQKQVYKRKTE 277

  Fly   237 KEMELYRKAISVWEEKMIRLGHIDVVRHGNLIDP------PEPKPRKT 278
            ...:.|.||::.:::.......::.|.    :||      |.|.|..|
  Rat   278 AAKKEYLKALAAYKDNQECQATVETVE----LDPVPQSQTPSPPPVTT 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TFAM	NP_732527.1	HMGB-UBF_HMG-box	78..142	CDD:238686	10/66 (15%)
TFAM	NP_732527.1	HMGB-UBF_HMG-box	183..247	CDD:238686	18/64 (28%)
Tox4	NP_775446.2	NHP6B	140..>306	CDD:227935	40/221 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	155..227		19/123 (15%)
		Nuclear localization signal. /evidence=ECO:0000255	213..218		0/4 (0%)
		HMG-box	223..288	CDD:238037	18/64 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	304..335		6/22 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	436..458
		PHA03160	<464..530	CDD:165431
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5648
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900