DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TFAM and Ubtf

DIOPT Version :9

Sequence 1:	NP_732527.1	Gene:	TFAM / 42433	FlyBaseID:	FBgn0038805	Length:	284	Species:	Drosophila melanogaster
Sequence 2:	NP_001349473.1	Gene:	Ubtf / 21429	MGIID:	98512	Length:	764	Species:	Mus musculus

Alignment Length:	295	Identity:	70/295 - (23%)
Similarity:	108/295 - (36%)	Gaps:	102/295 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 PPRPKKPLTPYFRFMREQRPKLKAANPQITTVEVVRQLSKNWSDADAQLK--------------E 125
            |..|||||||||||..|:|.|....:|:::.:::.:.|||.:.:...:.|              |
Mouse   109 PDFPKKPLTPYFRFFMEKRAKYAKLHPEMSNLDLTKILSKKYKELPEKKKMKYIQDFQREKQEFE 173

  Fly   126 RLQAEFKRD--------------------QQI-YVEERTKY-----DATLTE------------- 151
            |..|.|:.|                    ||: |..|:..|     |||..|
Mouse   174 RNLARFREDHPDLIQNAKKSDIPEKPKTPQQLWYTHEKKVYLKVRPDATTKEVKDSLGKQWSQLS 238

  Fly   152 ------------EQRAEIKQLKQDLVD-----------------AKERRQLRKRVKELGRPKKPA 187
                        |||.|.:::.:|.:.                 .|..|||:.:..  |||.||.
Mouse   239 DKKRLKWIHKALEQRKEYEEIMRDYIQKHPELNISEEGITKSTLTKAERQLKDKFD--GRPTKPP 301

  Fly   188 ----SAFLRFIASERINTPQGDKQTYREWHQKTTAKWTRLSDSEKEVY---MQESRK--EMELYR 243
                |.:...:.:...:.|..::...      .:.:|..||..||:.|   ..:.:|  |:||.|
Mouse   302 PNSYSLYCAELMANMKDVPSTERMVL------CSQQWKLLSQKEKDAYHKKCDQKKKDYEVELLR 360

  Fly   244 KAISVWEEKMIR-LGHIDV--VRHGNLIDPPEPKP 275
            ...|:.||:..| ||...:  :.......|...||
Mouse   361 FLESLPEEEQQRVLGEEKMLNINKKQTTSPASKKP 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TFAM	NP_732527.1	HMGB-UBF_HMG-box	78..142	CDD:238686	27/98 (28%)
TFAM	NP_732527.1	HMGB-UBF_HMG-box	183..247	CDD:238686	16/72 (22%)
Ubtf	NP_001349473.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		HMG_box	112..179	CDD:395407	22/66 (33%)
		HMGB-UBF_HMG-box	196..261	CDD:238686	13/64 (20%)
		HMGB-UBF_HMG-box	299..358	CDD:238686	12/64 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	370..411		6/26 (23%)
		HMGB-UBF_HMG-box	407..470	CDD:238686
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	456..487
		HMG_box_5	479..562	CDD:373364
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	546..576
		HMGB-UBF_HMG-box	569..631	CDD:238686
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5648
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810