DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TFAM and Hmgb3

DIOPT Version :9

Sequence 1:	NP_732527.1	Gene:	TFAM / 42433	FlyBaseID:	FBgn0038805	Length:	284	Species:	Drosophila melanogaster
Sequence 2:	NP_001280552.1	Gene:	Hmgb3 / 15354	MGIID:	1098219	Length:	200	Species:	Mus musculus

Alignment Length:	189	Identity:	47/189 - (24%)
Similarity:	79/189 - (41%)	Gaps:	38/189 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 GLPPRPKKPLTPYFRFMREQRPKLKAANPQITT--VEVVRQLSKNWSDADAQLKERLQAEFKRDQ 135
            |.|.:||..::.|..|::..|.:.|..||::..  .|..::.|:.|....::.|.:.....|.|
Mouse     4 GDPKKPKGKMSAYAFFVQTCREEHKKKNPEVPVNFAEFSKKCSERWKTMSSKEKSKFDEMAKAD- 67

  Fly   136 QIYVEERTKYDATLTEEQRAEIKQLKQDLVDAKERRQLRKRVKELGRPKKPASAFLRF------- 193
                  :.:||           :::| |...||.    .|:.|:...||:|.|.|..|
Mouse    68 ------KVRYD-----------REMK-DYGPAKG----GKKKKDPNAPKRPPSGFFLFCSEFRPK 110

  Fly   194 IASERINTPQGDKQTYREWHQKTTAKWTRLSDSEKEVYMQESRKEMELYRKAISVWEEK 252
            |.|.......||..      :|....|..|||:||:.|:.::.|..|.|.|.::.::.|
Mouse   111 IKSTNPGISIGDVA------KKLGEMWNNLSDNEKQPYVTKAAKLKEKYEKDVADYKSK 163

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TFAM	NP_732527.1	HMGB-UBF_HMG-box	78..142	CDD:238686	14/65 (22%)
TFAM	NP_732527.1	HMGB-UBF_HMG-box	183..247	CDD:238686	22/70 (31%)
Hmgb3	NP_001280552.1	HMG_box_2	13..78	CDD:370242	15/83 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	71..97		10/41 (24%)
		HMG_box	93..160	CDD:366139	22/72 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	161..200		1/3 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5648
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1641977at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48112
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920