DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TFAM and Hmg20b

DIOPT Version :9

Sequence 1:	NP_732527.1	Gene:	TFAM / 42433	FlyBaseID:	FBgn0038805	Length:	284	Species:	Drosophila melanogaster
Sequence 2:	XP_006513311.1	Gene:	Hmg20b / 15353	MGIID:	1341190	Length:	415	Species:	Mus musculus

Alignment Length:	215	Identity:	46/215 - (21%)
Similarity:	87/215 - (40%)	Gaps:	61/215 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 LPPRPKKPLTPYFRFMREQRPKLKAANPQITTVEVVRQLSKNWSDADAQLKERLQAEFKRDQQIY 138
            ||..||.|:|.|.||:.|:|.:::..:|.:...|:.:.|...||......|:|...|.::::|.|
Mouse    66 LPNGPKAPVTGYVRFLNERREQIRTRHPDLPFPEITKMLGAEWSKLQPAEKQRYLDEAEKEKQQY 130

  Fly   139 VEERTKYDAT-----LTEE-QRAEIKQ------------------------------LKQDLVDA 167
            ::|...|..:     .||: |..:||:                              ..::.:|
Mouse   131 LKELWAYQQSEAYKVCTEKIQENKIKKEDSSSGLMNTLLNGHKGVDCDGFSTFDVPIFTEEFLD- 194

  Fly   168 KERRQLRKRVKELGRPKKPASAFLRFIASERINTPQGDKQTYREWHQKTTAKWTRLSDSEKEVYM 232
                |.:.|..||.|.:|...||            :......:...|..::...||   |:|:.:
Mouse   195 ----QNKAREAELRRLRKMNVAF------------EEQNAVLQRHTQSMSSARERL---EQELAL 240

  Fly   233 QESR-----KEMELYRKAIS 247
            :|.|     ::::..|:|::
Mouse   241 EERRTLALQQQLQAVRQALT 260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TFAM	NP_732527.1	HMGB-UBF_HMG-box	78..142	CDD:238686	19/63 (30%)
TFAM	NP_732527.1	HMGB-UBF_HMG-box	183..247	CDD:238686	12/68 (18%)
Hmg20b	XP_006513311.1	HMGB-UBF_HMG-box	70..134	CDD:238686	19/63 (30%)
		OmpH	190..>254	CDD:214922	16/83 (19%)
		FAM222A	<314..>400	CDD:373691
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5648
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810