DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5191 and DUR1,2

DIOPT Version :9

Sequence 1:	NP_650893.2	Gene:	CG5191 / 42431	FlyBaseID:	FBgn0038803	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_009767.1	Gene:	DUR1,2 / 852507	SGDID:	S000000412	Length:	1835	Species:	Saccharomyces cerevisiae

Alignment Length:	527	Identity:	120/527 - (22%)
Similarity:	199/527 - (37%)	Gaps:	147/527 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 SEEVVEAYIERCRQVNPLINAIVQDRFEEALEEAREIDNVIAMGINSVESMEELTPLLGIPVTVK 146
            |..::|:.:: .:.|.|:.||.:....:|.|....:|       :.|.|:.|.| ||.|:|:.||
Yeast    32 SLRLLESLLD-SQNVAPVDNAWISLISKENLLHQFQI-------LKSRENKETL-PLYGVPIAVK 87

  Fly   147 ESIAVKGMTNQAGRVFKTPQIA---KSDAPVVEQIKRSGGIILLVSNTPELCLLWETYNNVTG-- 206
            ::|.|:|:...|.    .|..|   ..|:.|||.::.:|.||:..:|..:.         .||
Yeast    88 DNIDVRGLPTTAA----CPSFAYEPSKDSKVVELLRNAGAIIVGKTNLDQF---------ATGLV 139

  Fly   207 QTKNPYDLKRTP---------GGSSGGEAALLASGASLLGLTSDIGGSSRLPAMFSGIWGHKPTP 262
            .|::||.  :||         ||||.|.|:::|.|...:.|.:|..||.|:||..:.:.|.|||.
Yeast   140 GTRSPYG--KTPCAFSKEHVSGGSSAGSASVVARGIVPIALGTDTAGSGRVPAALNNLIGLKPTK 202

  Fly   263 YAVSFKGHHPTSDFPKWGDFFTIAPMTRYAKDLPLLLKCMSDPTGPKLTLDRPISVNGIRFF--- 324
            ...|.:|..|..   |..|..:|..:.....:....:.|..||...:.:  ||...|.::.|
Yeast   203 GVFSCQGVVPAC---KSLDCVSIFALNLSDAERCFRIMCQPDPDNDEYS--RPYVSNPLKKFSSN 262

  Fly   325 -----------FMDNDGP---SGMMRPLSRDLHAAINRVATDFNAKRVNIRKMKWSLDISLSAML 375
                       :.:...|   |..:..|||   ...|.:..||..
Yeast   263 VTIAIPKNIPWYGETKNPVLFSNAVENLSR---TGANVIEIDFEP-------------------- 304

  Fly   376 TMKNIETIYHKTEEGEQPKTVCKETVKYFFGC---SDSILPSVIFGHLQNFMKIIPNSRHKHLAS 437
            .::....:|..|...|:     .:.::.|...   .:|:.|:||        .||..:: |:  |
Yeast   305 LLELARCLYEGTWVAER-----YQAIQSFLDSKPPKESLDPTVI--------SIIEGAK-KY--S 353

  Fly   438 IIEALKTEFK---------EMLGNDGVFLYPTFP-NTAHQHYQIYHKLLEPMY------------ 480
            .::....|:|         .:|.:..|...||.| |...|  |:..   ||:.
Yeast   354 AVDCFSFEYKRQGILQKVRRLLESVDVLCVPTCPLNPTMQ--QVAD---EPVLVNSRQGTWTNFV 413

  Fly   481 -MAIFNTLGLPVTNCMIGLDRRNLPMGIQVVANPGQDHLSLAVAREM--------ERRYGGW--- 533
             :|....|.:|.     |.....||.||.::.....|:..|.:|...        .|.||.:
Yeast   414 NLADLAALAVPA-----GFRDDGLPNGITLIGKKFTDYALLELANRYFQNIFPNGSRTYGTFTSS 473

  Fly   534 -VRPPSE 539
             |:|.::
Yeast   474 SVKPAND 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5191	NP_650893.2	GatA	61..537	CDD:223232	119/523 (23%)
CG5191	NP_650893.2	PRK07488	63..537	CDD:236030	119/523 (23%)
DUR1,2	NP_009767.1	allophanate_hyd	49..620	CDD:274265	116/509 (23%)
DUR1,2	NP_009767.1	urea_carbox	633..1832	CDD:274264
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0154
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810