DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5191 and Y53F4B.18

DIOPT Version :9

Sequence 1:	NP_650893.2	Gene:	CG5191 / 42431	FlyBaseID:	FBgn0038803	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_497103.1	Gene:	Y53F4B.18 / 190217	WormBaseID:	WBGene00013164	Length:	535	Species:	Caenorhabditis elegans

Alignment Length:	539	Identity:	187/539 - (34%)
Similarity:	294/539 - (54%)	Gaps:	34/539 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LEELWLRILGYIMRRFLRSAMIVFSWFVVPYSRYTNIKVIRRKLPPIRSHLLEIPAVDLAKLIRT 77
            |::.:|.:|..|...:..:...|| |.|..:.|.      |..:.|....||.|.|....::|..
Worm     7 LKKAFLNLLLTISAAYFYTIRFVF-WLVNTFFRE------RVYVTPPTDRLLLISATQAVQMISQ 64

  Fly    78 RKIKSEEVVEAYIERCRQVNPLINAIVQDRFEEALEEAREIDNVIAMG-INSVESMEELTPLLGI 141
            ::|.|..:||:||.|..|||..|||:|...||.|.|:|.|:|:.||:. .:.::...|..||.|:
Worm    65 KEISSTALVESYIHRIEQVNNTINAVVVKLFESAREQANEVDSFIALADEDDIKKKLEEKPLYGV 129

  Fly   142 PVTVKESIAVKGMTNQAGRVFKTPQIAKSD--APVVEQIKRSGGIILLVSNTPELCLLWETYNNV 204
            |.|:|:::.|:......| ||.. :..|.|  |..:::::.:|||:|.::|.||:|:..|:.|.:
Worm   130 PFTMKDALEVENEIITCG-VFNR-KSTKCDRTAEAIKRLQAAGGILLAITNVPEVCMWVESVNTI 192

  Fly   205 TGQTKNPYDLKRTPGGSSGGEAALLASGASLLGLTSDIGGSSRLPAMFSGIWGHKPTPYAVSFKG 269
            .|::|||||.:|..|||||||.|||.||.|::|:.||||||.|:||.|:|::|.||||..:...|
Worm   193 YGRSKNPYDARRMTGGSSGGEGALLGSGGSVIGVGSDIGGSIRMPAFFNGVFGLKPTPGVIPLIG 257

  Fly   270 HHPTSDFPKWGDFFTIAPMTRYAKDLPLLLKCMSDPTGPKLTLDRPISVNGIRFFFMDNDGPSGM 334
            |.|.....| .....|.||.|:|:||||:|:.|:......|.|..|:|...:|.|:|:....|.:
Worm   258 HVPEPTGYK-THMLRIGPMCRFAEDLPLMLRIMAGENAQSLNLHEPVSGKKLRVFYMEGITGSPI 321

  Fly   335 MRPLSRDLHAAINRVATDFNAKRVNIRKMKWSLDISLSAM----LTMKNIET--IYHK---TEEG 390
            ::||..::..|:.: |..|..::.:|......|..:..||    |:|....|  .::|   ..:|
Worm   322 IQPLEDEMRYALKK-AVRFLERKYDIVAQGIELPSAKHAMEFFTLSMHEDTTDPAFNKLMLCTKG 385

  Fly   391 EQPKTVC-KETVKYFFGCSDSILPSVIFGHLQNFMKIIPNSRHKHLASIIEALKTEFKEMLGNDG 454
            .:.:..| .|..||..|.|:..|..::.|.:.:.......:..|:|....:.||.:.||:||.||
Worm   386 TKGEVNCFTEIFKYMAGNSNHTLSGIVAGIIDSRDPPFSEAHTKNLLYKRDRLKRQVKELLGTDG 450

  Fly   455 VFLYPTFPNTAHQHYQIYHK--LLEPM---YMAIFNTLGLPVTNCMIGLDRRNLPMGIQVVANPG 514
            :.|:|::|.||     :||.  :|.|.   |.|::|.|.:||..|.:|||.|.||:|:||:.|..
Worm   451 ILLFPSWPCTA-----MYHNEPILAPFNFCYTALWNVLSVPVVQCPLGLDSRGLPLGVQVIGNQY 510

  Fly   515 QDHLSLAVAREMERRYGGW 533
            .|...:|:|:.:|..:.||
Worm   511 TDRNLIAIAQVLEEGFNGW 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5191	NP_650893.2	GatA	61..537	CDD:223232	176/491 (36%)
CG5191	NP_650893.2	PRK07488	63..537	CDD:236030	176/489 (36%)
Y53F4B.18	NP_497103.1	GatA	47..532	CDD:223232	176/492 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0154
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D852596at2759
OrthoFinder	1	1.000	-	-		FOG0002245
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43372
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X256
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.920