DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5191 and FAAH2

DIOPT Version :9

Sequence 1:	NP_650893.2	Gene:	CG5191 / 42431	FlyBaseID:	FBgn0038803	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_777572.2	Gene:	FAAH2 / 158584	HGNCID:	26440	Length:	532	Species:	Homo sapiens

Alignment Length:	555	Identity:	209/555 - (37%)
Similarity:	320/555 - (57%)	Gaps:	45/555 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLKSIVTVIRLHLEELWLRILGYIMRRFLRSAMIVFSWFVVPYSRYTNIKVIRRKLPPIRSHLLE 65
            |..|....|:|.|    ||.||:::....|:|:::           ...|...:...|:...||.
Human     1 MAPSFTARIQLFL----LRALGFLIGLVGRAALVL-----------GGPKFASKTPRPVTEPLLL 50

  Fly    66 IPAVDLAKLIRTRKIKSEEVVEAYIERCRQVNPLINAIVQDRFEEALEEAREIDNVIAMGINSVE 130
            :..:.||||||.||:|..:||:|||.|.:.|||:||.||:.|||||::||..:|..:|.......
Human    51 LSGMQLAKLIRQRKVKCIDVVQAYINRIKDVNPMINGIVKYRFEEAMKEAHAVDQKLAEKQEDEA 115

  Fly   131 SMEELTPLLGIPVTVKESIAVKGMTNQAGRVFKTPQIAKSDAPVVEQIKRSGGIILLVSNTPELC 195
            ::|...|.||:|:||||:..::||.|.:|.:.:...|||:||.||..:|.:|.|.|.::|..|||
Human   116 TLENKWPFLGVPLTVKEAFQLQGMPNSSGLMNRRDAIAKTDATVVALLKGAGAIPLGITNCSELC 180

  Fly   196 LLWETYNNVTGQTKNPYDLKRTPGGSSGGEAALLASGASLLGLTSDIGGSSRLPAMFSGIWGHKP 260
            :.:|:.|.:.|::.|||||:...|||||||...||:..|::|:.||||||.|:||.|:||:||||
Human   181 MWYESSNKIYGRSNNPYDLQHIVGGSSGGEGCTLAAACSVIGVGSDIGGSIRMPAFFNGIFGHKP 245

  Fly   261 TPYAVSFKGHHPTSDFPKWGD---FFTIAPMTRYAKDLPLLLKCMSDPTGPKLTLDRPISVNGIR 322
            :|..|..||..|.:    .|.   |....||.|||:||..:||.|:.|...:|.||..:.:..::
Human   246 SPGVVPNKGQFPLA----VGAQELFLCTGPMCRYAEDLAPMLKVMAGPGIKRLKLDTKVHLKDLK 306

  Fly   323 FFFMDNDGPSGMMRPLSRDLHAAINRVATDF------NAKRVNIRKMKWSLDISLSAMLTMKNIE 381
            |::|::||.|.:|..:.:||.....:|....      :.:.|.::|||:|..:.: ||::.|.
Human   307 FYWMEHDGGSFLMSKVDQDLIMTQKKVVVHLETILGASVQHVKLKKMKYSFQLWI-AMMSAKG-- 368

  Fly   382 TIYHKTEE--------GEQPKTVCK--ETVKYFFGCSDSILPSVIFGHLQNFMKIIPNSRHKHLA 436
               |..:|        |:..|.|..  |.:|:..|.|...:||:....|:..:: ..|.:::...
Human   369 ---HDGKEPVKFVDLLGDHGKHVSPLWELIKWCLGLSVYTIPSIGLALLEEKLR-YSNEKYQKFK 429

  Fly   437 SIIEALKTEFKEMLGNDGVFLYPTFPNTAHQHYQIYHKLLEPMYMAIFNTLGLPVTNCMIGLDRR 501
            ::.|:|:.|..:|||:|||||||:.|..|.:|:....:.....|..:|:.||||||.|.:||:.:
Human   430 AVEESLRKELVDMLGDDGVFLYPSHPTVAPKHHVPLTRPFNFAYTGVFSALGLPVTQCPLGLNAK 494

  Fly   502 NLPMGIQVVANPGQDHLSLAVAREMERRYGGWVRP 536
            .||:||||||.|..|||:||||:.:|:.:||||.|
Human   495 GLPLGIQVVAGPFNDHLTLAVAQYLEKTFGGWVCP 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5191	NP_650893.2	GatA	61..537	CDD:223232	196/495 (40%)
CG5191	NP_650893.2	PRK07488	63..537	CDD:236030	196/493 (40%)
FAAH2	NP_777572.2	GatA	48..526	CDD:223232	192/488 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0154
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.69812	Normalized mean entropy	S4795
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D395077at33208
OrthoFinder	1	1.000	-	-		FOG0002245
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43372
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X256
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.830