Protein Alignment DPCoAC and SLC25A4

DIOPT Version :10

• Sequence 1: NP_650891.1
• Gene: DPCoAC / 42429
• FlyBaseID: FBgn0067783
• Length: 365
• Species: Drosophila melanogaster
• Sequence 2: NP_001142.2
• Gene: SLC25A4 / 291
• HGNCID: 10990
• Length: 298
• Species: Homo sapiens
• Alignment Length: 298
• Identity: 88/298 - (29%)
• Similarity: 143/298 - (47%)
• Gaps: 32/298 - (10%)

  Fly    77 ISGAAAGALAKTVIAPLDRTKINFQIRN-----DVPFSFRASLRYLQNTYANEGVLALWRGNSAT 136
            ::|..|.|::||.:||::|.|:..|:::     .....::..:..:......:|.|:.||||.|.
Human    13 LAGGVAAAVSKTAVAPIERVKLLLQVQHASKQISAEKQYKGIIDCVVRIPKEQGFLSFWRGNLAN 77

  Fly   137 MARIVPYAAIQFTAHEQWRRIL--HVDKDGTNTKGRRFLAGSL-----AGITSQSLTYPLDLARA 194
            :.|..|..|:.|...::::::.  .||:   :.:..|:.||:|     ||.||....||||.||.
Human    78 VIRYFPTQALNFAFKDKYKQLFLGGVDR---HKQFWRYFAGNLASGGAAGATSLCFVYPLDFART 139

  Fly   195 RMAVTDRYTG-----YRTLRQVFTKIWVEEGPRTLFRGYWATVLGVIPYAGTSFFTYETLKREYY 254
            |:| .|...|     :..|.....||:..:|.|.|::|:..:|.|:|.|....|..|:|.|.
Human   140 RLA-ADVGKGAAQREFHGLGDCIIKIFKSDGLRGLYQGFNVSVQGIIIYRAAYFGVYDTAKG--- 200

  Fly   255 EVVGNNKPNTLVSLAFGAAAGAAGQTASYPLDIVRRRMQTMRVNTAGGD-RYPTILETLVKIYRE 318
            .:......:..||.....:..|.....|||.|.|||||. |:....|.| .|...::...||.::
Human   201 MLPDPKNVHIFVSWMIAQSVTAVAGLVSYPFDTVRRRMM-MQSGRKGADIMYTGTVDCWRKIAKD 264

  Fly   319 EGVKNGFYKGLSMNWIKGPIAVGISF--STYDLIKAWL 354
            ||.| .|:||...|.::|   :|.:|  ..||.||.::
Human   265 EGAK-AFFKGAWSNVLRG---MGGAFVLVLYDEIKKYV 298

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DPCoAC	NP_650891.1	PTZ00169	77..336	CDD:240302	81/276 (29%)
SLC25A4	NP_001142.2	Solcar 1	6..98		21/84 (25%)
		PTZ00169	7..298	CDD:240302	88/296 (30%)
		Solcar 2	111..201		33/93 (35%)
		Solcar 3	212..297		32/89 (36%)
		Important for transport activity. /evidence=ECO:0000269|PubMed:27693233	235..240		4/5 (80%)
		Nucleotide carrier signature motif. /evidence=ECO:0000250|UniProtKB:P02722	235..240		4/5 (80%)