DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stat92E and STAT5B

DIOPT Version :9

Sequence 1:	NP_001262760.1	Gene:	Stat92E / 42428	FlyBaseID:	FBgn0016917	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_036580.2	Gene:	STAT5B / 6777	HGNCID:	11367	Length:	787	Species:	Homo sapiens

Alignment Length:	866	Identity:	277/866 - (31%)
Similarity:	413/866 - (47%)	Gaps:	170/866 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLWKRISSHVDCEQ-------RMAAYYEEKGMLELRLCLAPWIEDRIMSEQITPNTTDQLERVA 58
            |::|      :..:|       :|.|.|.:...:|:|..|:.|||.:........|..:.::  |
Human     1 MAVW------IQAQQLQGEALHQMQALYGQHFPIEVRHYLSQWIESQAWDSVDLDNPQENIK--A 57

  Fly    59 LKFNEDLQQKLLSTRTASDQA------LKFRVVELCALIQRI---SAVELYTHLRSGLQKELQLV 114
            .:..|.|.|:|  .:.|..|.      ||.::......:|..   ..:||...:|..|..|.:||
Human    58 TQLLEGLVQEL--QKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLV 120

  Fly   115 TE----KSVAATAGQSMPLNPYNMNNTPMVTGYMVDPSDLLAVSNSCNPPVVQGIGPIHNVQNTG 175
            .|    .|.|.:...:|......:|.|         ..:|..|:....       ..:..:|.|
Human   121 REANNGSSPAGSLADAMSQKHLQINQT---------FEELRLVTQDTE-------NELKKLQQT- 168

  Fly   176 IASPALGMVTPKVELYEVQHQIMQSLN---EFGNCAN-------ALKLLAQNYSYMLNSTSSPNA 230
                        .|.:.:|:|  :||.   :||..|.       :.:...|.....|.:.....|
Human   169 ------------QEYFIIQYQ--ESLRIQAQFGPLAQLSPQERLSRETALQQKQVSLEAWLQREA 219

  Fly   231 EA--AYRSLIDEKAAIVLTMRRSFMYYESLHEMVI--HELKNWRHQQAQAGNGAPFNEGSLDDIQ 291
            :.  .||..:.||....|.:.|.       .:.:|  .||..|:.:|..||||.| .|||||.:|
Human   220 QTLQQYRVELAEKHQKTLQLLRK-------QQTIILDDELIQWKRRQQLAGNGGP-PEGSLDVLQ 276

  Fly   292 RCFEMLESFI----------AHML------AAVKELMRVRLVTEEPELTHLLEQVQNAQKNLVCS 340
            ...|.|...|          .|:.      ..|:|::        .|:...:..:.:|   ||.|
Human   277 SWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEML--------AEVNATITDIISA---LVTS 330

  Fly   341 AFIVDKQPPQVMKTNTRFAASVRWLIGSQLGIHNNPPTVECIIMSEIQSQRFV-TRNTQMDNSSL 404
            .||::||||||:||.|:|||:||.|:|.:|.:|.|||.|:..|:||.|::..: ..||:.|
Human   331 TFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRND---- 391

  Fly   405 SGQSSGEIQNASSTMEYQQNNHVFSASFRNMQLKKIKRAEKKGTESVMDEKFALFFYTTTTV--N 467
               .||||.|....|||.|.....||.||||.||:|||::::|.|||.:|||.:.|.:..:|  |
Human   392 ---YSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRSDRRGAESVTEEKFTILFESQFSVGGN 453

  Fly   468 DFQIRVWTLSLPVVVIVHGNQEPQSWATITWDNAFAEIVRDPFMITDRVTWAQLSVALNIKFGS- 531
            :...:|.||||||||||||:|:..:.||:.|||||||..|.||.:.|:|.|.||..|||:||.:
Human   454 ELVFQVKTLSLPVVVIVHGSQDNNATATVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAE 518

  Fly   532 -CTGRSLTIDNLDFLYEKLQREERS---EY----ITWNQFCKEPMPDRSFTFWEWFFAIMKLTKD 588
             .:.|.||.:||.||.:||.....|   :|    ::|:||.:|.:|.|::|||:||..:|::.|.
Human   519 VQSNRGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGRNYTFWQWFDGVMEVLKK 583

  Fly   589 HMLGMWKAGCIMGFINKTKAQTDLLRSVYGIGTFLLRFSDSELGGVTIA--YVNENGLVTMLAPW 651
            |:...|..|.|:||:||.:|. |||.:... |||||||||||:||:|||  :.::..:...|.|:
Human   584 HLKPHWNDGAILGFVNKQQAH-DLLINKPD-GTFLLRFSDSEIGGITIAWKFDSQERMFWNLMPF 646

  Fly   652 TARDFQVLNLADRIRDLDVLCWLHPSDRNASPVKRDVAFGEFYSKRQEPEP---LVLDPVTGYVK 713
            |.|||.:.:||||:.||:.|.::.| ||     .:|    |.|||...|.|   .....|.||||
Human   647 TTRDFSIRSLADRLGDLNYLIYVFP-DR-----PKD----EVYSKYYTPVPCESATAKAVDGYVK 701

  Fly   714 STL------HVHVCRNGENGSTS---GTPHHAQESMQLGNISPQSGITFY--SPARLEESDS--D 765
            ..:      .|:...:...||.:   ..|..|        :.||:....|  :|..:.::|.  |
Human   702 PQIKQVVPEFVNASADAGGGSATYMDQAPSPA--------VCPQAHYNMYPQNPDSVLDTDGDFD 758

  Fly   766 ASETAEALERI--VIGAQPND 784
            ..:|.:...|:  ::| :|.|
Human   759 LEDTMDVARRVEELLG-RPMD 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stat92E	NP_001262760.1	STAT_int	2..119	CDD:214942	30/136 (22%)
		STAT_alpha	151..340	CDD:279369	46/218 (21%)
		STAT_bind	342..587	CDD:280939	120/256 (47%)
		SH2_STAT_family	578..696	CDD:198175	51/119 (43%)
STAT5B	NP_036580.2	STAT_int	2..124	CDD:308484	30/131 (23%)
		STAT_alpha	141..330	CDD:307245	49/238 (21%)
		Required for interaction with NMI. /evidence=ECO:0000269\|PubMed:9989503	232..321		26/104 (25%)
		STAT_bind	332..582	CDD:308483	120/256 (47%)
		SH2_STAT5b	573..717	CDD:198283	61/155 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146380
Domainoid	1	1.000	124	1.000	Domainoid score	I5544
eggNOG	1	0.900	-	-		E1_KOG3667
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	317	1.000	Inparanoid score	I2548
Isobase	1	0.950	-	0	Normalized mean entropy	S6183
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D166575at33208
OrthoFinder	1	1.000	-	-		FOG0001643
OrthoInspector	1	1.000	-	-		otm40793
orthoMCL	1	0.900	-	-		OOG6_104819
Panther	1	1.100	-	-	LDO	PTHR11801
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2821
SonicParanoid	1	1.000	-	-		X1200
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.740