DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stat92E and STAT5A

DIOPT Version :9

Sequence 1:	NP_001262760.1	Gene:	Stat92E / 42428	FlyBaseID:	FBgn0016917	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_001275647.1	Gene:	STAT5A / 6776	HGNCID:	11366	Length:	794	Species:	Homo sapiens

Alignment Length:	882	Identity:	272/882 - (30%)
Similarity:	408/882 - (46%)	Gaps:	202/882 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 DCEQRMAAYYEEKGMLELRLCLAPWIEDRIMSEQITPNTTDQLERVALKFNEDLQQKLLSTRTAS 76
            |..::|...|.:...:|:|..||.|||.:........|..|:.:  |.:..|.|.|:|  .:.|.
Human    13 DALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQ--ATQLLEGLVQEL--QKKAE 73

  Fly    77 DQA------LKFRVVELCALIQRI---SAVELYTHLRSGLQKELQLVTEKSVAATAGQSMPLNPY 132
            .|.      ||.::......:|:.   ..:||...:|..|..|.:||.|
Human    74 HQVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRHILYNEQRLVRE---------------- 122

  Fly   133 NMNNTPMVTGYMVDPSDLLAVSNSCNPPVVQGIGPIHNVQNTGIASPALGMVTPKVELYEVQH-Q 196
                                 :|:|:.|             .||...|:..          :| |
Human   123 ---------------------ANNCSSP-------------AGILVDAMSQ----------KHLQ 143

  Fly   197 IMQSLNEF----GNCANALKLLAQNYSYML---------------NSTSSPNAEAAYRSLIDEKA 242
            |.|:..|.    .:..|.||.|.|...|.:               .:..||....:..:.:.:|.
Human   144 INQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQFAQLAQLSPQERLSRETALQQKQ 208

  Fly   243 AIV--------LTMRRSFMYYESLHEMVIH------------ELKNWRHQQAQAGNGAPFNEGSL 287
            ..:        .|:::..:.....|:..:.            ||..|:.:|..||||.| .||||
Human   209 VSLEAWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGP-PEGSL 272

  Fly   288 DDIQRCFEMLESFI----------AHML------AAVKELMRVRLVTEEPELTHLLEQVQNAQKN 336
            |.:|...|.|...|          .|:.      ..|:|::        .|:...:..:.:|
Human   273 DVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEML--------AEVNATITDIISA--- 326

  Fly   337 LVCSAFIVDKQPPQVMKTNTRFAASVRWLIGSQLGIHNNPPTVECIIMSEIQSQRFVTRNTQMDN 401
            ||.|.||::||||||:||.|:|||:||.|:|.:|.:|.|||.|:..|:||.|::      :.:.|
Human   327 LVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAK------SLLKN 385

  Fly   402 SSLSGQSSGEIQNASSTMEYQQNNHVFSASFRNMQLKKIKRAEKKGTESVMDEKFALFFYTTTTV 466
            .:...:.||||.|....|||.|.....||.||||.||:||||:::|.|||.:|||.:.|.:..:|
Human   386 ENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRADRRGAESVTEEKFTVLFESQFSV 450

  Fly   467 --NDFQIRVWTLSLPVVVIVHGNQEPQSWATITWDNAFAEIVRDPFMITDRVTWAQLSVALNIKF 529
              |:...:|.||||||||||||:|:..:.||:.|||||||..|.||.:.|:|.|.||..|||:||
Human   451 GSNELVFQVKTLSLPVVVIVHGSQDHNATATVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKF 515

  Fly   530 GS--CTGRSLTIDNLDFLYEKLQREERS---EY----ITWNQFCKEPMPDRSFTFWEWFFAIMKL 585
            .:  .:.|.||.:||.||.:||.....|   :|    ::|:||.:|.:|..::|||:||..:|::
Human   516 KAEVQSNRGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGVMEV 580

  Fly   586 TKDHMLGMWKAGCIMGFINKTKAQTDLLRSVYGIGTFLLRFSDSELGGVTIAYVNENGLVTM--L 648
            .|.|....|..|.|:||:||.:|. |||.:... |||||||||||:||:|||:..::....:  |
Human   581 LKKHHKPHWNDGAILGFVNKQQAH-DLLINKPD-GTFLLRFSDSEIGGITIAWKFDSPERNLWNL 643

  Fly   649 APWTARDFQVLNLADRIRDLDVLCWLHPSDRNASPVKRDVAFGEFYSKRQEPEPLVLDPVTGYV- 712
            .|:|.|||.:.:||||:.||..|.::.| ||     .:|..|.::|:      |::...|.|||
Human   644 KPFTTRDFSIRSLADRLGDLSYLIYVFP-DR-----PKDEVFSKYYT------PVLAKAVDGYVK 696

  Fly   713 ---KSTLHVHVCRNGENGSTSGT-----PHHAQESMQLGNISPQSGITFY--SPARLEESDS--D 765
               |..:...|..:.:.|.:|.|     |..|        :.||:....|  :|..:.:.|.  |
Human   697 PQIKQVVPEFVNASADAGGSSATYMDQAPSPA--------VCPQAPYNMYPQNPDHVLDQDGEFD 753

  Fly   766 ASET---AEALERIVIGAQPNDPVISEITD--ALLTS 797
            ..||   |..:|.::  .:|.|.:.|.::.  .|.||
Human   754 LDETMDVARHVEELL--RRPMDSLDSRLSPPAGLFTS 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stat92E	NP_001262760.1	STAT_int	2..119	CDD:214942	30/115 (26%)
		STAT_alpha	151..340	CDD:279369	47/244 (19%)
		STAT_bind	342..587	CDD:280939	118/255 (46%)
		SH2_STAT_family	578..696	CDD:198175	51/119 (43%)
STAT5A	NP_001275647.1	STAT_int	2..124	CDD:308484	30/151 (20%)
		STAT_alpha	141..330	CDD:307245	41/200 (21%)
		STAT_bind	332..582	CDD:308483	118/255 (46%)
		SH2_STAT5a	573..712	CDD:198284	58/152 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	773..794		5/16 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146379
Domainoid	1	1.000	124	1.000	Domainoid score	I5544
eggNOG	1	0.900	-	-		E1_KOG3667
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	317	1.000	Inparanoid score	I2548
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D166575at33208
OrthoFinder	1	1.000	-	-		FOG0001643
OrthoInspector	1	1.000	-	-		otm40793
orthoMCL	1	0.900	-	-		OOG6_104819
Panther	1	1.100	-	-	O	PTHR11801
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2821
SonicParanoid	1	1.000	-	-		X1200
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790