DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stat92E and STAT4

DIOPT Version :9

Sequence 1:	NP_001262760.1	Gene:	Stat92E / 42428	FlyBaseID:	FBgn0016917	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_001230764.1	Gene:	STAT4 / 6775	HGNCID:	11365	Length:	748	Species:	Homo sapiens

Alignment Length:	822	Identity:	218/822 - (26%)
Similarity:	361/822 - (43%)	Gaps:	163/822 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLWKRISS-HVDCEQRMAAYYEEKGMLELRLCLAPWIEDRIMSEQITPNTTDQLERVALKFNED 64
            ||.|.::.. .:...:::..:|::...:|:|..||.|||::              :..|...||.
Human     1 MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIENQ--------------DWEAASNNET 51

  Fly    65 LQQKLLSTRTASDQALKFRVVELCALIQRISAVELYTHLRSGLQKELQLVTE-KSVAATAGQSMP 128
            :...||..          .:::|...:.|:|.           :|.|.|:.. |.:.........
Human    52 MATILLQN----------LLIQLDEQLGRVSK-----------EKNLLLIHNLKRIRKVLQGKFH 95

  Fly   129 LNPYNMNNTPMVTGYMVDPSDLLAVSNSCNPPVVQGIGPIHNVQNTGIASPALGMVTPKVELYEV 193
            .||  |:...:::..:.:...:||.:|.   ||.   ||:.....:...|.....|..||...:.
Human    96 GNP--MHVAVVISNCLREERRILAAANM---PVQ---GPLEKSLQSSSVSERQRNVEHKVAAIKN 152

  Fly   194 QHQIMQSLNEFGNCANALKLLAQNYSYMLNSTSSPNAEAAYRSLIDEKAAIVLTMRR-----SFM 253
            ..|:.:...::      |:.|...:.|...:..:.:......::::::   |||::.     .|.
Human   153 SVQMTEQDTKY------LEDLQDEFDYRYKTIQTMDQSDKNSAMVNQE---VLTLQEMLNSLDFK 208

  Fly   254 YYESL-------HE-------MVIHELKNWRHQQAQAGNGAPFNEGSLDDIQRCFEMLESFIAHM 304
            ..|:|       ||       |:|.||::|:.:|..|..|.|.:.| ||.:|.||.:|...:..:
Human   209 RKEALSKMTQIIHETDLLMNTMLIEELQDWKRRQQIACIGGPLHNG-LDQLQNCFTLLAESLFQL 272

  Fly   305 LAAVKEL--MRVRLVTE-EP---ELTHLLEQVQNAQKNLVCSAFIVDKQP--------PQVMKTN 355
            ...:::|  ...::..| :|   :.||:||:|.....||..::|:|::||        |.|:||.
Human   273 RRQLEKLEEQSTKMTYEGDPIPMQRTHMLERVTFLIYNLFKNSFVVERQPCMPTHPQRPLVLKTL 337

  Fly   356 TRFAASVRWLIGSQLGIHNNPPTVECII---MSEIQSQRFVTRNTQMDNSSLSGQSSGEIQNASS 417
            .:|...:|.||  :|...|....|:..|   :|.:.::|||...|.:...|:...|:|.:
Human   338 IQFTVKLRLLI--KLPELNYQVKVKASIDKNVSTLSNRRFVLCGTNVKAMSIEESSNGSL----- 395

  Fly   418 TMEYQQNNHVFSASFRNMQLKKIK-RAEKKGTES---VMDEKFALFFYTTTTVNDFQIRVWTLSL 478
                       |..||::|.|::| .|..||.|.   |.:|..::.|.|...:....|.:.|.||
Human   396 -----------SVEFRHLQPKEMKSSAGGKGNEGCHMVTEELHSITFETQICLYGLTIDLETSSL 449

  Fly   479 PVVVIVHGNQEPQSWATITWDNAFAEIVRDPFMITD--RVTWAQLSVALNIKFGSCTGRSLTIDN 541
            |||:|.:.:|.|.:||:|.|.|......::.....:  ..|.:||...::.:|.|..||.|..|.
Human   450 PVVMISNVSQLPNAWASIIWYNVSTNDSQNLVFFNNPPPATLSQLLEVMSWQFSSYVGRGLNSDQ 514

  Fly   542 LDFLYEKL--QREERSEYITWNQFCKEPMPDRSFTFWEWFFAIMKLTKDHMLGMWKAGCIMGFIN 604
            |..|.|||  |......::||.:||||.:|.:|||||.|..||:.|.|.|:|.:|..|.:|||::
Human   515 LHMLAEKLTVQSSYSDGHLTWAKFCKEHLPGKSFTFWTWLEAILDLIKKHILPLWIDGYVMGFVS 579

  Fly   605 KTKAQTDLLRSVYGIGTFLLRFSDSELGGVTIAYV--NENGLVTM--LAPWTARDFQVLNLADRI 665
            |.|.:  ||......||||||||:|.|||:|..:|  :|:|.|..  :.|:.......|..||.:
Human   580 KEKER--LLLKDKMPGTFLLRFSESHLGGITFTWVDHSESGEVRFHSVEPYNKGRLSALPFADIL 642

  Fly   666 RDLDV----------LCWLHPSDRNASPVKRDVAFGEFYSKRQEPEPLVLDPVT-----GYVKST 715
            ||..|          |.:|:|.      :.:|.|||:.||.    :|..:...|     |||.|.
Human   643 RDYKVIMAENIPENPLKYLYPD------IPKDKAFGKHYSS----QPCEVSRPTERGDKGYVPSV 697

  Fly   716 -LHVHVCRNGENGSTSGTPHHAQESMQLG---------NISP 747
             :.:...|     |.|..||...:.:.:.         |:||
Human   698 FIPISTIR-----SDSTEPHSPSDLLPMSPSVYAVLRENLSP 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stat92E	NP_001262760.1	STAT_int	2..119	CDD:214942	22/118 (19%)
		STAT_alpha	151..340	CDD:279369	49/213 (23%)
		STAT_bind	342..587	CDD:280939	84/263 (32%)
		SH2_STAT_family	578..696	CDD:198175	48/131 (37%)
STAT4	NP_001230764.1	STAT_int	2..121	CDD:214942	27/155 (17%)
		STAT4_CCD	140..312	CDD:341079	40/181 (22%)
		STAT4_DBD	316..473	CDD:341086	53/174 (30%)
		SH2_STAT4	553..700	CDD:198238	55/158 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	40	1.000	Domainoid score	I12531
eggNOG	1	0.900	-	-		E1_KOG3667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D166575at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11801
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920