DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stat92E and STAT3

DIOPT Version :9

Sequence 1:	NP_001262760.1	Gene:	Stat92E / 42428	FlyBaseID:	FBgn0016917	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	XP_024306664.1	Gene:	STAT3 / 6774	HGNCID:	11364	Length:	802	Species:	Homo sapiens

Alignment Length:	872	Identity:	219/872 - (25%)
Similarity:	350/872 - (40%)	Gaps:	203/872 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLWKRISSHVDCE--QRMAAYYEEKGMLELRLCLAPWIEDR-------------IMSEQITPNT 50
            |:.|.:: ..:|..  :::...|.:...:|||..||||||.:             ::...:....
Human     1 MAQWNQL-QQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNLLGEI 64

  Fly    51 TDQLERVALKFNEDLQQKLLSTRTASDQALKFRVVELCALIQRISAVELYTHLRSGLQKELQLVT 115
            ..|..|...:.|...|..|...:    |.|:.|.:|....|.||.|..|:...|       .|.|
Human    65 DQQYSRFLQESNVLYQHNLRRIK----QFLQSRYLEKPMEIARIVARCLWEESR-------LLQT 118

  Fly   116 EKSVAATAGQ-SMPLNPYNMNNTPMVTGYMVD----PSDLLAVSNSCNPPVVQGIGPIHNVQNTG 175
            ..:.|...|| :.|..........|:..::.|    ..||           .|.:..:.|:|:.
Human   119 AATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDL-----------EQKMKVVENLQDD- 171

  Fly   176 IASPALGMVTPKVELYEVQHQI------MQSLNEFGNCANALKLLAQNYSYMLNSTSSPNAEAAY 234
                           ::..::.      ||.||  ||..:..:...|....||.:     .:...
Human   172 ---------------FDFNYKTLKSQGDMQDLN--GNNQSVTRQKMQQLEQMLTA-----LDQMR 214

  Fly   235 RSLIDEKAAIVLTMRRSFMYYESLHEMVIHELKNWRHQQAQAGNGAPFNEGSLDDIQRCFEMLES 299
            ||::.|.|.::..|.    |.:.  .:...||.:|:.:|..|..|.|.|        .|.:.||:
Human   215 RSIVSELAGLLSAME----YVQK--TLTDEELADWKRRQQIACIGGPPN--------ICLDRLEN 265

  Fly   300 FIAHM----------LAAVKELMRVRLVTEEPELTH---LLEQVQNAQKNLVCSAFIVDKQP--- 348
            :|..:          :..::||.:......:|.:.|   |.|::....:||:.|||:|::||
Human   266 WITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMP 330

  Fly   349 -----PQVMKTNTRFAASVRWLI-----GSQLGIHNNPPTVECI------IMSEIQSQRF--VTR 395
                 |.|:||..:|...||.|:     ..||.|.      .||      :.:...|::|  :..
Human   331 MHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIK------VCIDKDSGDVAALRGSRKFNILGT 389

  Fly   396 NTQM------DNSSLS--------GQSSGEIQNASSTM----EYQQNN--HVFSASFRNMQLKKI 440
            ||::      :|.|||        |:||.. |.||...    ...|:.  .:|..:.|..:....
Human   390 NTKVMNMEESNNGSLSAEFKHLVCGRSSPS-QRASGCRRGLGRASQDTCLFLFLQTLREQRCGNG 453

  Fly   441 KRAEKKGTESVMDEKFALFFYTTTTVNDFQIRVWTLSLPVVVIVHGNQEPQSWATITWDNAFAEI 505
            .||....:..|.:|...:.|.|.......:|.:.|.|||||||.:..|.|.:||:|.|.|.....
Human   454 GRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNN 518

  Fly   506 VRDPFMITDRV--TWAQLSVALNIKFGSCTGRSLTIDNLDFLYEKL----------QREERSEYI 558
            .::....|...  ||.|::..|:.:|.|.|.|.|:|:.|..|.|||          |       |
Human   519 PKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQ-------I 576

  Fly   559 TWNQFCKEPMPDRSFTFWEWFFAIMKLTKDHMLGMWKAGCIMGFINKTKAQTDLLRSVYGIGTFL 623
            ||.:||||.|..:.|:||.|...|:.|.|.::|.:|..|.|||||:|.:.:..|  |....||||
Human   577 TWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAIL--STKPPGTFL 639

  Fly   624 LRFSD-SELGGVTIAYVNEN----GLVTMLAPWTARDFQVLNLAD-----RIRD-----LDVLCW 673
            ||||: |:.||||..:|.::    ..:..:.|:|.:....::.|:     :|.|     :..|.:
Human   640 LRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVY 704

  Fly   674 LHPSDRNASPVKRDVAFGEFYSKRQEPEPLVLDP--VTGYVKSTLHVHVCRNGENGSTS----GT 732
            |:|.      :.::.|||: |.:.:..|....||  ...|:|:..   :|......|.:    .:
Human   705 LYPD------IPKEEAFGK-YCRPESQEHPEADPGSAAPYLKTKF---ICVTPTTCSNTIDLPMS 759

  Fly   733 PHHAQESMQLGN----ISPQSGITFYS 755
            |......||.||    ..|.:|..|.|
Human   760 PRTLDSLMQFGNNGEGAEPSAGGQFES 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stat92E	NP_001262760.1	STAT_int	2..119	CDD:214942	29/131 (22%)
		STAT_alpha	151..340	CDD:279369	38/207 (18%)
		STAT_bind	342..587	CDD:280939	87/297 (29%)
		SH2_STAT_family	578..696	CDD:198175	41/132 (31%)
STAT3	XP_024306664.1	STAT_int	2..120	CDD:214942	29/129 (22%)
		STAT_alpha	141..319	CDD:307245	42/225 (19%)
		STAT_bind	321..605	CDD:308483	87/297 (29%)
		SH2_STAT3	586..747	CDD:198237	51/172 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	40	1.000	Domainoid score	I12531
eggNOG	1	0.900	-	-		E1_KOG3667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D166575at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11801
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920