DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stat92E and STAT2

DIOPT Version :9

Sequence 1:	NP_001262760.1	Gene:	Stat92E / 42428	FlyBaseID:	FBgn0016917	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	XP_011536999.1	Gene:	STAT2 / 6773	HGNCID:	11363	Length:	859	Species:	Homo sapiens

Alignment Length:	810	Identity:	186/810 - (22%)
Similarity:	322/810 - (39%)	Gaps:	191/810 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLWKRISSHVDC---EQRMAAYYEEKGMLELRLCLAPWIEDRIMSEQITPNTTDQLERVALKFN 62
            |:.|:.: .::|.   :|....|......:::|..||.||||:...|....:...:...:...|.
Human     1 MAQWEML-QNLDSPFQDQLHQLYSHSLLPVDIRQYLAVWIEDQNWQEAALGSDDSKATMLFFHFL 64

  Fly    63 EDLQQKLLSTRTASDQ---ALKFRVVELCALIQRIS-----AVELYTHLRSGLQKELQLVTEKSV 119
            :.|..:  ..|.:.|.   .|:..:.:.|..||..|     ..|:..:|.  |:::..|:..:..
Human    65 DQLNYE--CGRCSQDPESLLLQHNLRKFCRDIQPFSQDPTQLAEMIFNLL--LEEKRILIQAQRA 125

  Fly   120 AATAGQSMPLNPYNMNNTPMVTGYMVDPSDLLAVSNSCNPPVVQGIGPI----------HNVQNT 174
            ....|:.:...|.......:.:..:    ||.|:...    :|:.|..:          :.:|..
Human   126 QLEQGEPVLETPVESQQHEIESRIL----DLRAMMEK----LVKSISQLKDQQDVFCFRYKIQAK 182

  Fly   175 GIASPALGMVTPKVELYEVQHQ--IMQSLNEFGNCANALKLLAQNYSYMLNSTSSPNAEAAYRSL 237
            |        .||.::.::.:.|  :.::|||.                          :...:.:
Human   183 G--------KTPSLDPHQTKEQKILQETLNEL--------------------------DKRRKEV 213

  Fly   238 IDEKAAIV--LTMRRSFMYYESLHEMVIHELKNWRHQQAQAGNGAPFNEGSLDDIQRCFEMLESF 300
            :|...|::  ||         :|.|:::.:|:.|:.||.:|...||.:.| |:.::..|......
Human   214 LDASKALLGRLT---------TLIELLLPKLEEWKAQQQKACIRAPIDHG-LEQLETWFTAGAKL 268

  Fly   301 IAHMLAAVKELMRVRLVT--EEPELTHLLEQVQNAQ-----KNLVCSAFIVDKQP--------PQ 350
            :.|:...:|||..:..:.  ::..||..:: ::|||     :.|:..||:|:.||        |.
Human   269 LFHLRQLLKELKGLSCLVSYQDDPLTKGVD-LRNAQVTELLQRLLHRAFVVETQPCMPQTPHRPL 332

  Fly   351 VMKTNTRFAASVRWLIGSQLG---------IHNNPPTVECIIMSEIQSQRFVTRNTQMDNSSL-- 404
            ::||.::|....|.|:..|.|         |..|||          |.|.|...|....|...
Human   333 ILKTGSKFTVRTRLLVRLQEGNESLTVEVSIDRNPP----------QLQGFRKFNILTSNQKTLT 387

  Fly   405 --SGQSSGEIQNASSTMEYQQNNHVFSASFRNMQLKKIKRAEKKGTESVMDEKFALFFYTTTTVN 467
              .|||.|.|.:.......:|.:....            :...||...|.:|...:.|....|..
Human   388 PEKGQSQGLIWDFGYLTLVEQRSGGSG------------KGSNKGPLGVTEELHIISFTVKYTYQ 440

  Fly   468 DFQIRVWTLSLPVVVIVHGNQEPQSWATITWDNAFAEIVRDP----------FMITDRVTWAQLS 522
            ..:..:.|.:||||:|.:.||...:||::.|.|..:..::..          |....:..|:.|.
Human   441 GLKQELKTDTLPVVIISNMNQLSIAWASVLWFNLLSPNLQPTLLPPLQNQQFFSNPPKAPWSLLG 505

  Fly   523 VALNIKFGSCTGRSLTIDNLDFLYEKLQREE-RSE--YITWNQFCKEPMPDRSFTFWEWFFAIMK 584
            .||:.:|.|..||.|..|.|..|..||..:. |:|  .::|..|.|...|.....||.|...|::
Human   506 PALSWQFSSYVGRGLNSDQLSMLRNKLFGQNCRTEDPLLSWADFTKRESPPGKLPFWTWLDKILE 570

  Fly   585 LTKDHMLGMWKAGCIMGFINKTKAQTDLLRSVYGIGTFLLRFSDSELGGVTIAYV----NENGLV 645
            |..||:..:|..|.||||:::::.:..|.:::  .||||||||:|..||:|.::|    ::..|:
Human   571 LVHDHLKDLWNDGRIMGFVSRSQERRLLKKTM--SGTFLLRFSESSEGGITCSWVEHQDDDKVLI 633

  Fly   646 TMLAPWTARDFQVLNLADRIRDLDVLC----------WLHPSDRNASPVKRDVAFGEFY------ 694
            ..:.|:|....|.|.|.:.||...:|.          :|:|.      :.||.|||.:|
Human   634 YSVQPYTKEVLQSLPLTEIIRHYQLLTEENIPENPLRFLYPR------IPRDEAFGCYYQEKVNL 692

  Fly   695 --------------SKRQEPE---PLVLDP 707
                          |.||..|   ||.|.|
Human   693 QERRKYLKHRLIVVSNRQVDELQQPLELKP 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stat92E	NP_001262760.1	STAT_int	2..119	CDD:214942	25/127 (20%)
		STAT_alpha	151..340	CDD:279369	37/209 (18%)
		STAT_bind	342..587	CDD:280939	71/278 (26%)
		SH2_STAT_family	578..696	CDD:198175	42/151 (28%)
STAT2	XP_011536999.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	40	1.000	Domainoid score	I12531
eggNOG	1	0.900	-	-		E1_KOG3667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D166575at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11801
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920