DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stat92E and STAT1

DIOPT Version :9

Sequence 1:	NP_001262760.1	Gene:	Stat92E / 42428	FlyBaseID:	FBgn0016917	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_001371820.1	Gene:	STAT1 / 6772	HGNCID:	11362	Length:	762	Species:	Homo sapiens

Alignment Length:	884	Identity:	219/884 - (24%)
Similarity:	371/884 - (41%)	Gaps:	216/884 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLWKRISSHVDCE--QRMAAYYEEKGMLELRLCLAPWIEDRIMSEQITPNTTDQLERVA----- 58
            ||.|..: ..:|.:  :::...|::...:|:|..||.|:|.:..|.....|.....|..|
Human     1 MSQWYEL-QQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDCSRMKCVNVKSPREHAANDVSF 64

  Fly    59 --LKFNEDLQQKLLSTRTASDQALKFRVVELCALIQRISAVELYTHLRSGLQKELQLVTEKSVAA 121
              ::|::.|.|       ..||..:|. :|...|:|.        ::|.. ::.||
Human    65 ATIRFHDLLSQ-------LDDQYSRFS-LENNFLLQH--------NIRKS-KRNLQ--------- 103

  Fly   122 TAGQSMPLNPYNMNNTPMVTGYMVDPSDLLAVSNSC---NPPVVQGIGPIHNVQNTGIASPALGM 183
                               ..:..||..:..:..||   ...:::.....:..|:..|.|..  |
Human   104 -------------------DNFQEDPIQMSMIIYSCLKEERKILENAQRFNQAQSGNIQSTV--M 147

  Fly   184 VTPKVEL----YEVQHQIMQSLNEFGNCANALKLLAQNYSYMLNSTSSPNAEAAYRSLIDEKAAI 244
            :..:.||    ..|:.::|...:|.    .:|:.|...|.:...:..:...|....:..|:|...
Human   148 LDKQKELDSKVRNVKDKVMCIEHEI----KSLEDLQDEYDFKCKTLQNREHETNGVAKSDQKQEQ 208

  Fly   245 VLTMRRSFMYYESLHEMVIH-------------------ELKNWRHQQAQAGNGAPFNEGSLDDI 290
            :| :::.::..::..:.|:|                   ||..|:.:|..|..|.|.| ..||.:
Human   209 LL-LKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWKRRQQSACIGGPPN-ACLDQL 271

  Fly   291 QRCFEMLESFIAHMLAAVKELMRVRLVTEEPELTHLLEQ---VQNAQ----------KNLVCSAF 342
            |..|.::...:..:...:|:|       ||.|..:..|.   .:|.|          :.|:.|:|
Human   272 QNWFTIVAESLQQVRQQLKKL-------EELEQKYTYEHDPITKNKQVLWDRTFSLFQQLIQSSF 329

  Fly   343 IVDKQP--------PQVMKTNTRFAASVRWLIGSQLGIHNNPPTVECIIMSEIQSQRFVTRNTQM 399
            :|::||        |.|:||..:|...:|.|:  :|...|....|:.:...::..     |||
Human   330 VVERQPCMPTHPQRPLVLKTGVQFTVKLRLLV--KLQELNYNLKVKVLFDKDVNE-----RNT-- 385

  Fly   400 DNSSLSGQSSGEIQNASS---TMEYQQNNHVFSASFRNMQLKKIKRAEKKGTES---VMDEKFAL 458
                :.|.....|....:   .|| :..|...:|.||::|||:.|.|..:..|.   |.:|..:|
Human   386 ----VKGFRKFNILGTHTKVMNME-ESTNGSLAAEFRHLQLKEQKNAGTRTNEGPLIVTEELHSL 445

  Fly   459 FFYTTTTVNDFQIRVWTLSLPVVVIVHGNQEPQSWATITWDNAFAEIVRDP-----FMITDRVTW 518
            .|.|........|.:.|.|||||||.:.:|.|..||:|.|.|.   :|.:|     |:......|
Human   446 SFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNM---LVAEPRNLSFFLTPPCARW 507

  Fly   519 AQLSVALNIKFGSCTGRSLTIDNLDFLYEKLQREERSE--YITWNQFCKEPMPDRSFTFWEWFFA 581
            ||||..|:.:|.|.|.|.|.:|.|:.|.|||.....|.  .|.|.:||||.:.|::|.||.|..:
Human   508 AQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWTRFCKENINDKNFPFWLWIES 572

  Fly   582 IMKLTKDHMLGMWKAGCIMGFINKTKAQTDLLRSVYGIGTFLLRFSDSEL-GGVTIAYV--NENG 643
            |::|.|.|:|.:|..|||||||:|.:.:. ||:.... ||||||||:|.. |.:|..:|  ::||
Human   573 ILELIKKHLLPLWNDGCIMGFISKERERA-LLKDQQP-GTFLLRFSESSREGAITFTWVERSQNG 635

  Fly   644 ---LVTMLAPWTARDFQVLNLADRIRDLDVLC----------WLHPSDRNASPVKRDVAFGEFYS 695
               ....:.|:|.::...:...|.||:..|:.          :|:|:      :.:|.|||::||
Human   636 GEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKYLYPN------IDKDHAFGKYYS 694

  Fly   696 KRQE-PEPLVLD--PVTGYVKSTL----HVHVCRNGENGSTSGTPHHAQESMQLGNISPQSGITF 753
            :.:| |||:.||  ..|||:|:.|    .||
Human   695 RPKEAPEPMELDGPKGTGYIKTELISVSEVH---------------------------------- 725

  Fly   754 YSPARLEESDSDASETAEALERI--VIGAQPNDPVISEI 790
              |:||:.:|:....:.|..:.:  ::|:...|.:::.:
Human   726 --PSRLQTTDNLLPMSPEEFDEVSRIVGSVEFDSMMNTV 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stat92E	NP_001262760.1	STAT_int	2..119	CDD:214942	26/125 (21%)
		STAT_alpha	151..340	CDD:279369	41/227 (18%)
		STAT_bind	342..587	CDD:280939	86/265 (32%)
		SH2_STAT_family	578..696	CDD:198175	44/133 (33%)
STAT1	NP_001371820.1	STAT_int	2..133	CDD:214942	30/176 (17%)
		STAT1_CCD	150..325	CDD:341076	34/187 (18%)
		STAT1_DBD	329..489	CDD:341083	52/176 (30%)
		SH2_STAT1	569..719	CDD:198235	55/157 (35%)
		STAT1_TAZ2bind	727..751	CDD:371931	4/23 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	40	1.000	Domainoid score	I12531
eggNOG	1	0.900	-	-		E1_KOG3667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D166575at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11801
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920