DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stat92E and stat5b

DIOPT Version :9

Sequence 1:	NP_001262760.1	Gene:	Stat92E / 42428	FlyBaseID:	FBgn0016917	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_001003984.1	Gene:	stat5b / 445474	ZFINID:	ZDB-GENE-040818-1	Length:	787	Species:	Danio rerio

Alignment Length:	793	Identity:	263/793 - (33%)
Similarity:	382/793 - (48%)	Gaps:	162/793 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLWKRISS-HVDCEQRMAAYYEEKGMLELRLCLAPWIEDRIMSEQITPNTTDQL--ERVALKFN 62
            |:||.:... ..|...:|.:.|.:...:|:|..||.|:|.:........|..|:.  :|:.....
Zfish     1 MALWIQAQQLQGDALHQMQSLYGQHFPIEVRQYLAQWLEAQPWDAIDLENQQDEFKAKRLLDGLI 65

  Fly    63 EDLQQKLLSTRTASDQALKFRV---------------VELCALIQRISAVELYTHLRSGLQKELQ 112
            ::||:|...........||.::               :||...::.|    |||        |.:
Zfish    66 QELQKKAEHQMGGDGFLLKIKLGHYATQLKNSYDACPLELVRCVKHI----LYT--------EQR 118

  Fly   113 LVTEKSVAATAGQSMPLNPYNMNNTPMVTGYMVDPSDLLAVSNSCNPPVVQGIGPI----HNVQN 173
            ||.|                                    .||:.:|    |.||:    ...|.
Zfish   119 LVQE------------------------------------ASNTSSP----GSGPVDGTPQRYQQ 143

  Fly   174 TGIASPALGMVTPKVE--LYEVQHQIMQSLNEFGNCANALKLLAQNYSYMLNSTSSPNAEAAYR- 235
            .......|.::|...|  |.::||.....:.::   ..:|::.||    :::..|.|..|.|.|
Zfish   144 INQTFEELRVMTQDTENDLRKLQHSQEYFIIQY---QESLRIQAQ----IVSLASLPPTERAQRE 201

  Fly   236 -SLIDEKAAIVLTMRRSF----MYYESLHE---------------MVIHELKNWRHQQAQAGNGA 280
             ||...|:.:...:.|..    .|.:.|.|               :|..||..|:.:|..||||.
Zfish   202 ASLQSRKSTLETWLTREANTLQKYRQELAEKHQRTLALLRKQQTVIVDDELIQWKRRQQLAGNGG 266

  Fly   281 PFNEGSLDDIQRCFEMLESFIAHMLAAVKELMRVRLVTE--------EPELTHLLEQVQNAQKNL 337
            | :||.||.:|...|.|...|....   :::.||..:|:        |..||.|...|.:....|
Zfish   267 P-SEGGLDILQAWCEKLADMIWQNR---QQIRRVEHLTQQLPIPGPTEELLTELNAIVTDIISTL 327

  Fly   338 VCSAFIVDKQPPQVMKTNTRFAASVRWLIGSQLGIHNNPPTVECIIMSEIQSQRFV-TRNTQMDN 401
            |.|.||::||||||:||.|:|:|:||.|:|.:|.:|.|||.|:..|:||.|::..: ..||:
Zfish   328 VTSTFIIEKQPPQVLKTQTKFSATVRLLVGGKLNVHMNPPQVKATIISEQQAKAILKNENTR--- 389

  Fly   402 SSLSGQSSGEIQNASSTMEYQQNNHVFSASFRNMQLKKIKRAEKKGTESVMDEKFALFFYT--TT 464
               ..:|||:|.|.:..|||.|.....||.||.|.||:|||::::|.|||.:|||.:.|.:  :.
Zfish   390 ---KSESSGDILNNNCVMEYHQTTGNLSAHFRTMSLKRIKRSDRRGAESVTEEKFTILFESQFSV 451

  Fly   465 TVNDFQIRVWTLSLPVVVIVHGNQEPQSWATITWDNAFAEIVRDPFMITDRVTWAQLSVALNIKF 529
            .||:....|.||||||||||||:|:..:.||:.|||||:|..|.||::.|:|.|.||..|||:|:
Zfish   452 GVNELVFHVKTLSLPVVVIVHGSQDNNATATVLWDNAFSEPGRVPFVVPDKVVWPQLCEALNMKY 516

  Fly   530 GS--CTGRSLTIDNLDFLYEKL-------QREERSEYITWNQFCKEPMPDRSFTFWEWFFAIMKL 585
            .|  .:.|.|:.|||.||.:|.       ..:..|..|||:||.:|.:|.|:||||:||..:::|
Zfish   517 KSEVQSDRGLSEDNLVFLAQKAFSSSSNNPEDYSSMTITWSQFNRESLPGRNFTFWQWFDGVIEL 581

  Fly   586 TKDHMLGMWKAGCIMGFINKTKAQTDLLRSVYGIGTFLLRFSDSELGGVTIAYVNEN------GL 644
            .|.|:...|..|.|:||:||.:|| |:|.|... |||||||||||:||:|||:|.||      .:
Zfish   582 MKKHLKSHWNDGAILGFLNKQQAQ-DMLMSKPN-GTFLLRFSDSEIGGITIAWVAENPNKAGERM 644

  Fly   645 VTMLAPWTARDFQVLNLADRIRDLDVLCWLHPS--------------------DRNASPVKRDVA 689
            |..|.|:|.:||.:.:|||||.||:.|.:|:||                    |....|..:.|.
Zfish   645 VWNLMPFTTKDFSIRSLADRISDLNHLLFLYPSQPKEEVFSRYCTPPNSKAVGDGYVKPEIKQVV 709

  Fly   690 FGEFYSKRQEPEP 702
            ..||.|...||.|
Zfish   710 KVEFSSPNPEPSP 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stat92E	NP_001262760.1	STAT_int	2..119	CDD:214942	29/134 (22%)
		STAT_alpha	151..340	CDD:279369	56/223 (25%)
		STAT_bind	342..587	CDD:280939	117/256 (46%)
		SH2_STAT_family	578..696	CDD:198175	58/143 (41%)
stat5b	NP_001003984.1	STAT_int	2..124	CDD:280940	29/169 (17%)
		STAT_alpha	141..330	CDD:279369	50/199 (25%)
		STAT_bind	332..583	CDD:280939	117/256 (46%)
		SH2	574..709	CDD:301589	55/136 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579988
Domainoid	1	1.000	125	1.000	Domainoid score	I5411
eggNOG	1	0.900	-	-		E1_KOG3667
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	338	1.000	Inparanoid score	I2347
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D166575at33208
OrthoFinder	1	1.000	-	-		FOG0001643
OrthoInspector	1	1.000	-	-		otm25035
orthoMCL	1	0.900	-	-		OOG6_104819
Panther	1	1.100	-	-	O	PTHR11801
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1200
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.760