DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stat92E and stat5a

DIOPT Version :9

Sequence 1:	NP_001262760.1	Gene:	Stat92E / 42428	FlyBaseID:	FBgn0016917	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_919368.2	Gene:	stat5a / 369197	ZFINID:	ZDB-GENE-030820-2	Length:	785	Species:	Danio rerio

Alignment Length:	883	Identity:	287/883 - (32%)
Similarity:	419/883 - (47%)	Gaps:	198/883 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLWKRISS-HVDCEQRMAAYYEEKGMLELRLCLAPWIEDRIMSEQITPNTTDQLERVALKFNED 64
            |::|.:... ..|...:|.:.|.:...:|:|..|:.|||.::.         |.::.      |:
Zfish     1 MAVWIQAQQLQGDALHQMQSLYGQHFPIEVRHYLSQWIEGQLW---------DAIDL------EN 50

  Fly    65 LQQKLLSTRTASDQALKFRVVELCALIQRISAVELYTHLRSGLQKELQLVTEKSVAATAGQSMPL 129
            .|::|.:.|.            |.:|||                 |||...|..|    |:.
Zfish    51 PQEELKAKRL------------LDSLIQ-----------------ELQKKAEHQV----GED--- 79

  Fly   130 NPYNMNNTPMVTGYMVD------PSDLLAVSNSCNPPVVQGIGPIHNVQN------TGIASPALG 182
                        |:::.      .|.|.:..:.|...:|:.|..|...:.      |..:||..|
Zfish    80 ------------GFLLKIKLGHYASQLKSTYDRCPLELVRCIKHILYTEQRLVREATNSSSPVGG 132

  Fly   183 MVTPKVELYEVQHQIMQSLNEF----GNCANALKLLAQNYSY-------------MLNSTSS-PN 229
            ::....:.|   |||.|:..|.    .:..|.|:.|.....|             .|:|.:: |.
Zfish   133 LMDSMSQKY---HQINQAFEELRILTQDTENDLRKLQHTQEYFIIQYQESLRIQAQLSSLATLPP 194

  Fly   230 AEAAYR--SLIDEKAAIVLTMRRSF----MYYESLHE---------------MVIHELKNWRHQQ 273
            |:...|  ||:.::|.:...:.|..    .|..||.|               ::..||..|:.:|
Zfish   195 ADRQLREPSLLSKRATVEAWLTREANTLQKYRLSLAEKHQKTLALLRKQQTVILDDELIQWKRRQ 259

  Fly   274 AQAGNGAPFNEGSLDDIQRCFEMLESFIAHMLAAVK--ELMRVRLVTEEP---ELTHLLEQVQNA 333
            ..||||.| .||.||.:|...|.|...|......::  |.:|.:|....|   .||.|...:.:.
Zfish   260 QLAGNGGP-PEGGLDILQSWCEKLAETIWQNRQQIRRAEHLRQQLPIPGPIEELLTDLNSTITDI 323

  Fly   334 QKNLVCSAFIVDKQPPQVMKTNTRFAASVRWLIGSQLGIHNNPPTVECIIMSEIQSQRFV-TRNT 397
            ...||.|.||::||||||:||.|:|||:||.|:|.:|.:|.|||.|:..|:||.|::..: ..||
Zfish   324 ISTLVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKALLKNENT 388

  Fly   398 QMDNSSLSGQSSGEIQNASSTMEYQQNNHVFSASFRNMQLKKIKRAEKKGTESVMDEKFALFFYT 462
            :.|       |||||.|.:..|||.|.....||.||||.||:|:|::::|.|||.:|||.:.|.:
Zfish   389 RND-------SSGEILNNNCVMEYHQTTGTLSAHFRNMSLKRIRRSDRRGAESVTEEKFTILFES 446

  Fly   463 TTTV--NDFQIRVWTLSLPVVVIVHGNQEPQSWATITWDNAFAEIVRDPFMITDRVTWAQLSVAL 525
            ..:|  |:...:|.||||||||||||:|:..:.||:.|||||||..|.||::.|:|.||||..||
Zfish   447 QFSVGGNELGFQVKTLSLPVVVIVHGSQDNNATATVLWDNAFAEPGRVPFIVPDKVLWAQLCEAL 511

  Fly   526 NIKFGS--CTGRSLTIDNLDFLYEKL-------QREERSEYITWNQFCKEPMPDRSFTFWEWFFA 581
            |:|:.:  .:.|.|..:||.||.:|.       ..:.|:..:||:||.:|.:|.|:||||:||..
Zfish   512 NMKYKAEVQSNRGLCEENLVFLAQKAFSSSSVNPDDYRNMTMTWSQFNRESLPGRNFTFWQWFDG 576

  Fly   582 IMKLTKDHMLGMWKAGCIMGFINKTKAQTDLLRSVYGIGTFLLRFSDSELGGVTIAYVNEN---- 642
            :|:|||.|:...|..|.|:||:||.:|| |:|.|... |||||||||||:||:|||:|.||
Zfish   577 VMELTKKHLKPHWNDGAILGFVNKQQAQ-DMLMSKPN-GTFLLRFSDSEIGGITIAWVAENPNKA 639

  Fly   643 --GLVTMLAPWTARDFQVLNLADRIRDLDVLCWLHPSDRNASPVKRDVAFGEFYSKRQEPEPLVL 705
              .:|..|.|:|.:||.:.:|||||.||:.|.:|:| ||     .:|..|.::|:      |.:.
Zfish   640 GERMVWNLMPYTTKDFSIRSLADRISDLNHLLFLYP-DR-----PKDEVFSKYYT------PPLS 692

  Fly   706 DPVTGYVKSTLHVHVCRNGENGSTSGTPHHAQESMQLGNISPQSGITFYSPARLEESDSDASETA 770
            ..|.||||..:...|            |..|..     |..|.:..|:        .|..||..|
Zfish   693 KAVDGYVKPQIKQVV------------PEFATP-----NPDPAANPTY--------MDHVASSPA 732

  Fly   771 EALERIVIGAQPNDPVISEITDALLTSNYRHGDFGMAD 808
            .:... ..|..|  |:...:.||       .|||.:.|
Zfish   733 VSAPH-PYGLYP--PMADPMLDA-------DGDFDLDD 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stat92E	NP_001262760.1	STAT_int	2..119	CDD:214942	23/117 (20%)
		STAT_alpha	151..340	CDD:279369	57/238 (24%)
		STAT_bind	342..587	CDD:280939	120/256 (47%)
		SH2_STAT_family	578..696	CDD:198175	59/123 (48%)
stat5a	NP_919368.2	STAT_int	2..124	CDD:280940	32/184 (17%)
		STAT_alpha	141..330	CDD:279369	49/192 (26%)
		STAT_bind	332..582	CDD:280939	120/256 (47%)
		SH2	573..710	CDD:301589	67/162 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579987
Domainoid	1	1.000	125	1.000	Domainoid score	I5411
eggNOG	1	0.900	-	-		E1_KOG3667
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	338	1.000	Inparanoid score	I2347
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D166575at33208
OrthoFinder	1	1.000	-	-		FOG0001643
OrthoInspector	1	1.000	-	-		otm25035
orthoMCL	1	0.900	-	-		OOG6_104819
Panther	1	1.100	-	-	LDO	PTHR11801
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2821
SonicParanoid	1	1.000	-	-		X1200
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.790