Protein Alignment Stat92E and stat4

DIOPT Version :10

• Sequence 1: NP_001262760.1
• Gene: Stat92E / 42428
• FlyBaseID: FBgn0016917
• Length: 818
• Species: Drosophila melanogaster
• Sequence 2: XP_005167937.1
• Gene: stat4 / 368519
• ZFINID: ZDB-GENE-030616-264
• Length: 732
• Species: Danio rerio
• Alignment Length: 815
• Identity: 209/815 - (25%)
• Similarity: 364/815 - (44%)
• Gaps: 151/815 - (18%)

  Fly     1 MSLWKRISSHVDCE--QRMAAYYEEKGMLELRLCLAPWIEDR---------IMSEQITPNTTDQL 54
            ||.||:: ..:|.:  :::..:|::...:|||..||.|||.:         .|:..:..|...||
Zfish     1 MSQWKQV-QQLDIKFLEQVDYFYDDNFPMELRQVLANWIESQDWETASNHESMATVLFNNFLIQL 64

  Fly    55 ERVALKFNEDLQQKLLSTRTASDQALKFRVVELCALIQRISAVELYTHLRSGLQKELQLVTEKSV 119
            ||...:     :|..|....     || |:.....:..:.:.:::...:.:.|::|.::::
Zfish    65 ERQCSQ-----EQNFLHRHN-----LK-RIFHQIQVKYKANPLQMAAVICNCLREERRILS---- 114

  Fly   120 AATAGQSMPLNPYNMNNTPMVTGYMVDPSDLLAVSNSCNPPVVQGIGPIHNVQNTGIASPALGMV 184
            .|:..:..||.....|:..:....::|  :.:||..|....:.|.:..:.::|:.
Zfish   115 TASMQEQGPLEKSMQNSAALEKQKVLD--NKVAVIRSSVQMLDQAVKYLEDMQDD---------- 167

  Fly   185 TPKVELYEVQHQIMQSLNEFGNCANALKLLAQNYSYMLNSTSSPNAEAAYRS--LIDEKAAIVLT 247
                  ::.:::.:|..:.....::::|........:||.......|...::  :|.|..|::.:
Zfish   168 ------FDFRYKTLQLRDPLERNSSSMKQEVTTLQEILNRLDFKRKEFLSKTADVIKEIDALISS 226

  Fly   248 MRRSFMYYESLHEMVIHELKNWRHQQAQAGNGAPFNEGSLDDIQRCFEMLESFIAHMLAAVKELM 312
            ....             |||.|:.:|..|..|.|...| ||.:|..|.:....:..:...:.:|.
Zfish   227 QLNP-------------ELKEWKRRQQIACIGGPVLIG-LDQLQNWFTLTAQSLFQIKRQLDKLG 277

  Fly   313 RVRL-VTEE--------PELTHLLEQVQNAQKNLVCSAFIVDKQP--------PQVMKTNTRFAA 360
            .:.| ||.|        |::.   |||:....:|:.|:|:|:|||        |.::||..:|..
Zfish   278 ELILKVTYESDPIPLQRPQME---EQVKYLIYHLIKSSFVVEKQPCMPTHLQKPLIIKTQVQFTT 339

  Fly   361 SVRWLIGSQLGIHNNPPTVECIIMSEIQSQRFVTRNTQMDNSSLSGQSSGE---IQNASSTMEYQ 422
            .||.|:.                :.|:..|..|  .|..|.....|:.:.:   :.|.:..|:.:
Zfish   340 KVRLLVK----------------LPEVDYQLKV--KTTFDKDLPPGKVNRQFFILTNNTKVMDVE 386

  Fly   423 QNNHVFSASFRNMQLKKIK-RAEKKGTE---SVMDEKFALFFYTTTTVNDFQIRVWTLSLPVVVI 483
            ::....|..||::|||:.| ....||.|   ||.:|..:|.|.....:....|.:.|.|||:|||
Zfish   387 ESTGCLSVEFRHLQLKERKCPTGGKGNEGPLSVTEELHSLNFEAMLMLQGLDIDLETCSLPLVVI 451

  Fly   484 VHGNQEPQSWATITWDNAFAEIVRDP-----FMITDRVTWAQLSVALNIKFGSCTGRSLTIDNLD 543
            .:.:|.|..||::.|.|...:   ||     |....|.:|:|||..|:.:|.|..||.|..:.|:
Zfish   452 SNVSQLPGGWASVMWYNLLTD---DPKNLAFFSNPLRASWSQLSEVLSWQFSSFAGRGLNKEQLN 513

  Fly   544 FLYEKLQREERSE---YITWNQFCKEPMPDRSFTFWEWFFAIMKLTKDHMLGMWKAGCIMGFINK 605
            .|.:||..:..|.   .::|::||||.:|.:||:||.|..:|:.|.|.|:|.:|..||||||::|
Zfish   514 MLGDKLLGQHGSYNDCQVSWSKFCKEVIPGKSFSFWMWLDSILDLIKKHLLPVWIDGCIMGFVSK 578

  Fly   606 TKAQTDLLRSVYGIGTFLLRFSDSELGGVTIAYV--NENGLVTMLA--PWTARDFQVLNLADRIR 666
             :.:..||:.... ||||||||:|.|||:|..:|  :|||....::  |:|......|.:||.||
Zfish   579 -EMERALLKEKEP-GTFLLRFSESHLGGITFTWVEQDENGDPKFISVEPYTKNRLNALPIADIIR 641

  Fly   667 DLDVLC----------WLHPSDRNASPVKRDVAFGEFYSKRQEPE----PLVLDPVTGYVKSTLH 717
            |..|:.          :|:|.      :.:|.|||:.|:.:|...    |..|.|::..|.:.
Zfish   642 DYKVIADGVVPENPLNFLYPD------IPKDEAFGKHYNSQQNKVCPYIPTHLVPISHRVPAQ-- 698

  Fly   718 VHVCRNGENGSTSG-----TPHHAQESMQLGNISP 747
             |.|.:.|...:.|     |.|.:....:....||
Zfish   699 -HSCSSPEPPMSPGMYEIITQHLSPFEFESAMSSP 732

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Stat92E	NP_001262760.1	STAT_int	2..119	CDD:214942	26/127 (20%)
		STAT_CCD	191..338	CDD:341075	30/157 (19%)
		STAT_DBD	342..502	CDD:341082	49/174 (28%)
		SH2_STAT_family	578..696	CDD:198175	49/131 (37%)
stat4	XP_005167937.1	STAT_int	2..118	CDD:214942	27/131 (21%)
		STAT4_CCD	137..309	CDD:341079	36/206 (17%)
		STAT_DBD	313..470	CDD:355796	49/174 (28%)
		SH2	551..692	CDD:472789	53/148 (36%)