DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stat92E and stat4

DIOPT Version :9

Sequence 1:	NP_001262760.1	Gene:	Stat92E / 42428	FlyBaseID:	FBgn0016917	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	XP_005167937.1	Gene:	stat4 / 368519	ZFINID:	ZDB-GENE-030616-264	Length:	732	Species:	Danio rerio

Alignment Length:	815	Identity:	209/815 - (25%)
Similarity:	364/815 - (44%)	Gaps:	151/815 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLWKRISSHVDCE--QRMAAYYEEKGMLELRLCLAPWIEDR---------IMSEQITPNTTDQL 54
            ||.||:: ..:|.:  :::..:|::...:|||..||.|||.:         .|:..:..|...||
Zfish     1 MSQWKQV-QQLDIKFLEQVDYFYDDNFPMELRQVLANWIESQDWETASNHESMATVLFNNFLIQL 64

  Fly    55 ERVALKFNEDLQQKLLSTRTASDQALKFRVVELCALIQRISAVELYTHLRSGLQKELQLVTEKSV 119
            ||...:     :|..|....     || |:.....:..:.:.:::...:.:.|::|.::::
Zfish    65 ERQCSQ-----EQNFLHRHN-----LK-RIFHQIQVKYKANPLQMAAVICNCLREERRILS---- 114

  Fly   120 AATAGQSMPLNPYNMNNTPMVTGYMVDPSDLLAVSNSCNPPVVQGIGPIHNVQNTGIASPALGMV 184
            .|:..:..||.....|:..:....::|  :.:||..|....:.|.:..:.::|:.
Zfish   115 TASMQEQGPLEKSMQNSAALEKQKVLD--NKVAVIRSSVQMLDQAVKYLEDMQDD---------- 167

  Fly   185 TPKVELYEVQHQIMQSLNEFGNCANALKLLAQNYSYMLNSTSSPNAEAAYRS--LIDEKAAIVLT 247
                  ::.:::.:|..:.....::::|........:||.......|...::  :|.|..|::.:
Zfish   168 ------FDFRYKTLQLRDPLERNSSSMKQEVTTLQEILNRLDFKRKEFLSKTADVIKEIDALISS 226

  Fly   248 MRRSFMYYESLHEMVIHELKNWRHQQAQAGNGAPFNEGSLDDIQRCFEMLESFIAHMLAAVKELM 312
            ....             |||.|:.:|..|..|.|...| ||.:|..|.:....:..:...:.:|.
Zfish   227 QLNP-------------ELKEWKRRQQIACIGGPVLIG-LDQLQNWFTLTAQSLFQIKRQLDKLG 277

  Fly   313 RVRL-VTEE--------PELTHLLEQVQNAQKNLVCSAFIVDKQP--------PQVMKTNTRFAA 360
            .:.| ||.|        |::.   |||:....:|:.|:|:|:|||        |.::||..:|..
Zfish   278 ELILKVTYESDPIPLQRPQME---EQVKYLIYHLIKSSFVVEKQPCMPTHLQKPLIIKTQVQFTT 339

  Fly   361 SVRWLIGSQLGIHNNPPTVECIIMSEIQSQRFVTRNTQMDNSSLSGQSSGE---IQNASSTMEYQ 422
            .||.|:.                :.|:..|..|  .|..|.....|:.:.:   :.|.:..|:.:
Zfish   340 KVRLLVK----------------LPEVDYQLKV--KTTFDKDLPPGKVNRQFFILTNNTKVMDVE 386

  Fly   423 QNNHVFSASFRNMQLKKIK-RAEKKGTE---SVMDEKFALFFYTTTTVNDFQIRVWTLSLPVVVI 483
            ::....|..||::|||:.| ....||.|   ||.:|..:|.|.....:....|.:.|.|||:|||
Zfish   387 ESTGCLSVEFRHLQLKERKCPTGGKGNEGPLSVTEELHSLNFEAMLMLQGLDIDLETCSLPLVVI 451

  Fly   484 VHGNQEPQSWATITWDNAFAEIVRDP-----FMITDRVTWAQLSVALNIKFGSCTGRSLTIDNLD 543
            .:.:|.|..||::.|.|...:   ||     |....|.:|:|||..|:.:|.|..||.|..:.|:
Zfish   452 SNVSQLPGGWASVMWYNLLTD---DPKNLAFFSNPLRASWSQLSEVLSWQFSSFAGRGLNKEQLN 513

  Fly   544 FLYEKLQREERSE---YITWNQFCKEPMPDRSFTFWEWFFAIMKLTKDHMLGMWKAGCIMGFINK 605
            .|.:||..:..|.   .::|::||||.:|.:||:||.|..:|:.|.|.|:|.:|..||||||::|
Zfish   514 MLGDKLLGQHGSYNDCQVSWSKFCKEVIPGKSFSFWMWLDSILDLIKKHLLPVWIDGCIMGFVSK 578

  Fly   606 TKAQTDLLRSVYGIGTFLLRFSDSELGGVTIAYV--NENGLVTMLA--PWTARDFQVLNLADRIR 666
             :.:..||:.... ||||||||:|.|||:|..:|  :|||....::  |:|......|.:||.||
Zfish   579 -EMERALLKEKEP-GTFLLRFSESHLGGITFTWVEQDENGDPKFISVEPYTKNRLNALPIADIIR 641

  Fly   667 DLDVLC----------WLHPSDRNASPVKRDVAFGEFYSKRQEPE----PLVLDPVTGYVKSTLH 717
            |..|:.          :|:|.      :.:|.|||:.|:.:|...    |..|.|::..|.:.
Zfish   642 DYKVIADGVVPENPLNFLYPD------IPKDEAFGKHYNSQQNKVCPYIPTHLVPISHRVPAQ-- 698

  Fly   718 VHVCRNGENGSTSG-----TPHHAQESMQLGNISP 747
             |.|.:.|...:.|     |.|.:....:....||
Zfish   699 -HSCSSPEPPMSPGMYEIITQHLSPFEFESAMSSP 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stat92E	NP_001262760.1	STAT_int	2..119	CDD:214942	26/127 (20%)
		STAT_alpha	151..340	CDD:279369	36/199 (18%)
		STAT_bind	342..587	CDD:280939	81/267 (30%)
		SH2_STAT_family	578..696	CDD:198175	49/131 (37%)
stat4	XP_005167937.1	STAT_int	2..118	CDD:214942	27/131 (21%)
		STAT_alpha	137..311	CDD:279369	37/208 (18%)
		STAT_bind	313..560	CDD:280939	81/267 (30%)
		SH2	551..692	CDD:301589	53/148 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D166575at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11801
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920