DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stat92E and Stat4

DIOPT Version :9

Sequence 1:	NP_001262760.1	Gene:	Stat92E / 42428	FlyBaseID:	FBgn0016917	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_001012226.1	Gene:	Stat4 / 367264	RGDID:	1305747	Length:	748	Species:	Rattus norvegicus

Alignment Length:	826	Identity:	214/826 - (25%)
Similarity:	361/826 - (43%)	Gaps:	171/826 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLWKRISS-HVDCEQRMAAYYEEKGMLELRLCLAPWIEDRIMSEQITPNTTDQLERVALKFNED 64
            ||.|.::.. .:...:::..:|::...:|:|..||.|||.:  ..::..|            ||.
  Rat     1 MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIETQ--DWEVASN------------NET 51

  Fly    65 LQQKLLSTRTASDQALKFRVVELCALIQRISAVELYTHLRSGLQKELQLVTE-KSVAATAGQSMP 128
            :...||..          .:::|...:.|:|.           :|.|.|:.. |.:.........
  Rat    52 MATILLQN----------LLIQLDEQLGRVSK-----------EKNLLLIHNLKRIRKVLQGKFH 95

  Fly   129 LNPYNMNNTPMVTGYMVDPSDLLAVSNSCNPPVVQGIGPIH-NVQNTGIA------SPALGMVTP 186
            .||  |:...:::..:.:...:||.:|.   |:.   ||:. ::|::.::      ...:..:..
  Rat    96 GNP--MHVAVVISNCLREERRILAAANM---PIQ---GPLEKSLQSSSVSERQRNVEHKVAAIKN 152

  Fly   187 KVELYEVQHQIMQSL-NEFGNCANALKLLAQ-------------NYSYMLNSTSSPNAEAAYR-- 235
            .|::.|...:.::.| :||......::.:.|             ....|||:......||..:
  Rat   153 SVQMTEQDTKYLEDLQDEFDYRYKTIQTMDQGDKNSILVNQEVLTLQEMLNNLDFKRKEALSKMT 217

  Fly   236 SLIDEKAAIVLTMRRSFMYYESLHEMVIHELKNWRHQQAQAGNGAPFNEGSLDDIQRCFEMLESF 300
            .:::|...:             ::.|::.||::|:.:|..|..|.|.:.| ||.:|.||.:|...
  Rat   218 QIVNETDLL-------------MNSMLLEELQDWKKRQQIACIGGPLHNG-LDQLQNCFTLLAES 268

  Fly   301 IAHMLAAVKELMR--VRLVTE-EP---ELTHLLEQVQNAQKNLVCSAFIVDKQP--------PQV 351
            :..:...:::|..  .::..| :|   :..||||:......||..::|:|::||        |.|
  Rat   269 LFQLRQQLEKLQEQSTKMTYEGDPIPAQRVHLLERATFLIYNLFKNSFVVERQPCMPTHPQRPMV 333

  Fly   352 MKTNTRFAASVRWLIGSQLGIHNNPPTVECII---MSEIQSQRFVTRNTQMDNSSLSGQSSGEIQ 413
            :||..:|...:|.||  :|...|....|:..|   :|.:.::|||...|.     :...||.|..
  Rat   334 LKTLIQFTVKLRLLI--KLPELNYQVKVKASIDKNVSTLSNRRFVLCGTH-----IKAMSSEESS 391

  Fly   414 NASSTMEYQQNNHVFSASFRNMQLKKIK-RAEKKGTES---VMDEKFALFFYTTTTVNDFQIRVW 474
            |.|.::|           ||::|.|::| ....||.|.   |.:|..::.|.|...:....|.:.
  Rat   392 NGSLSVE-----------FRHLQPKEMKCSTGSKGNEGCHMVTEELHSITFETQICLYGLTINLE 445

  Fly   475 TLSLPVVVIVHGNQEPQSWATITWDNAFAEIVRDPFMITD--RVTWAQLSVALNIKFGSCTGRSL 537
            |.|||||:|.:.:|.|.:||:|.|.|......::.....:  .||..||...::.:|.|..||.|
  Rat   446 TSSLPVVMISNVSQLPNAWASIIWYNVSTNDSQNLVFFNNPPSVTLGQLLEVMSWQFSSYVGRGL 510

  Fly   538 TIDNLDFLYEKL--QREERSEYITWNQFCKEPMPDRSFTFWEWFFAIMKLTKDHMLGMWKAGCIM 600
            ..|.|:.|.|||  |......::||.:||||.:|.::||||.|..||:.|.|.|:|.:|..|.||
  Rat   511 NSDQLNMLAEKLTVQSNYSDGHLTWAKFCKEHLPGKTFTFWTWLEAILDLIKKHILPLWIDGYIM 575

  Fly   601 GFINKTKAQTDLLRSVYGIGTFLLRFSDSELGGVTIAYV--NENGLVTM--LAPWTARDFQVLNL 661
            ||::|.|.:  ||......||||||||:|.|||:|..:|  :|||.|..  :.|:.......|..
  Rat   576 GFVSKEKER--LLLKDKMPGTFLLRFSESHLGGITFTWVDQSENGEVRFHSVEPYNKARLSALPF 638

  Fly   662 ADRIRDLDV----------LCWLHPSDRNASPVKRDVAFGEFYSKRQEPEPLVLDPVT-----GY 711
            ||.:||..|          |.:|:|.      :.:|.|||:.||.    :|..:...|     ||
  Rat   639 ADILRDYKVIMAENIPENPLKYLYPD------IPKDKAFGKHYSS----QPCEVSRPTERGDKGY 693

  Fly   712 VKST-LHVHVCRNGENGSTSGTPHHAQESMQLG---------NISP 747
            |.|. :.:...|     |.|..|....:.:.:.         |:||
  Rat   694 VPSVFIPISTIR-----SDSTEPQSPSDLLPMSPSAYAVLRENLSP 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stat92E	NP_001262760.1	STAT_int	2..119	CDD:214942	22/118 (19%)
		STAT_alpha	151..340	CDD:279369	43/217 (20%)
		STAT_bind	342..587	CDD:280939	85/263 (32%)
		SH2_STAT_family	578..696	CDD:198175	50/131 (38%)
Stat4	NP_001012226.1	STAT_int	2..121	CDD:214942	27/155 (17%)
		STAT_alpha	140..314	CDD:279369	36/187 (19%)
		STAT_bind	316..562	CDD:280939	85/263 (32%)
		SH2_STAT4	553..700	CDD:198238	57/158 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	42	1.000	Domainoid score	I12095
eggNOG	1	0.900	-	-		E1_KOG3667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D166575at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11801
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920