DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stat92E and stat6

DIOPT Version :9

Sequence 1:	NP_001262760.1	Gene:	Stat92E / 42428	FlyBaseID:	FBgn0016917	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_001124062.1	Gene:	stat6 / 337413	ZFINID:	ZDB-GENE-030131-9359	Length:	758	Species:	Danio rerio

Alignment Length:	806	Identity:	244/806 - (30%)
Similarity:	384/806 - (47%)	Gaps:	156/806 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLWKRISSHVD--CEQRMAAYYEEKGMLELRLCLAPWIEDRIMSEQITPNTTDQLERVALKFNE 63
            |:.|.:::.|:.  ..:.:...|.....|::|..||.|||    .:|......|..|       :
Zfish     1 MAQWAQMTQHIQFLTTEVLNELYPVTFPLDIRHYLASWIE----GQQWDSFDVDNRE-------Q 54

  Fly    64 DLQQKLLSTRTASDQALKF---------RVVELCALIQRIS---------AVELYTHLRSGLQKE 110
            :.|.:||     |||.:..         .|||...| |.:|         .::|...:|..|:||
Zfish    55 ESQAQLL-----SDQMVMLLHQVAKQNPNVVEKVKL-QHMSKNWSVLYPQPLQLVRTVREILRKE 113

  Fly   111 LQLVTEKSVAATAGQSMPLNPYNMNNTPMVTGYMVDPSDLLAVSNSCNPPVVQGIGPIH------ 169
            ..::::.               ||...|..                  ||...|| |..
Zfish   114 RLILSQT---------------NMQFPPFA------------------PPPTNGI-PQQAWEEKK 144

  Fly   170 -NVQNTGIASPALGMVTPKVELYEVQHQI------MQSLNEFGNCANALKLLAQNYSYMLNSTSS 227
             :|:|  :.|..:.:...:..|:::|.::      :|.|:|....|...::  |...|  |:|..
Zfish   145 TDVEN--LMSKVMEIQNRRQTLHQLQEELNWEKETIQGLSEMDTGAKQKRI--QQIEY--NATIC 203

  Fly   228 PNAEAAYRSLIDEKAAIVLTMRRSFMYYESLHEMVIHELKNWRHQQAQAGNGAPFNEGSLDDIQR 292
              |:...:.|.|...|:           |.....::.::::||.:|.::..|.|||: .||.:|.
Zfish   204 --AQERVQFLCDAVGAL-----------EQCQSSLMLKIESWRWEQHRSTIGMPFND-ILDHLQT 254

  Fly   293 CFEMLESFIAHMLAAVKELMRV------RLVTEEPELTHLLEQVQNAQKNLVCSAFIVDKQPPQV 351
            ..|.| ..:...|.....||:|      ||.|.|..|..||       |.|:.::.:|:||||||
Zfish   255 WSEQL-LIVNGNLRQELMLMKVDHGDAERLRTLEENLARLL-------KTLIQNSLVVEKQPPQV 311

  Fly   352 MKTNTRFAASVRWLIGSQLGIHNNPPTVECIIMSEIQSQRFVTRNTQMDNSSLSGQSSGEIQNAS 416
            :||.::|:.:||:|:|.::. ...|..::..|::|.|:     ||.. ..|.:..::.||:.|::
Zfish   312 IKTQSKFSTTVRYLLGDKMA-PGKPVLLKAQIITEAQA-----RNLG-QQSVIPNENVGELLNST 369

  Fly   417 STMEYQQNNHVFSASFRNMQLKKIKRAEKKGTESVMDEKFALFFYT--TTTVNDFQIRVWTLSLP 479
            :.:|:...:....|:||||.:::||||::||:|||.:|||||.|.|  |.|..:....:.::|||
Zfish   370 TILEHNTTSKNTCATFRNMSIRRIKRADRKGSESVTEEKFALLFTTDITITGGERPYSLQSISLP 434

  Fly   480 VVVIVHGNQEPQSWATITWDNAFAEIVRDPFMITDRVTWAQLSVALNIKFGS--CTGRSLTIDNL 542
            |||||||:||..:.|||.||.||:|..|.||::.:||:|.|:..||:.||.|  .|.|.|...||
Zfish   435 VVVIVHGSQEINAMATIIWDCAFSEPNRIPFLVPERVSWQQMCGALSSKFMSEVQTTRGLDPLNL 499

  Fly   543 DFLYEKL--QREERSEY----ITWNQFCKEPMPDRSFTFWEWFFAIMKLTKDHMLGMWKAGCIMG 601
            .||.:|:  |.:...::    ::|.||.||.:|.|:||||:||...:.|||..:...|..|.|.|
Zfish   500 RFLGQKIFDQPDHPGDFENMLVSWAQFNKEVLPGRNFTFWQWFEGAIDLTKRCLRDYWTDGLIFG 564

  Fly   602 FINKTKAQTDLLRSVYGIGTFLLRFSDSELGGVTIAYV--NENG--LVTMLAPWTARDFQVLNLA 662
            ||.|......|.....|.  |||||||||:||:|||||  .|||  .|..:.|:|.:|.....|.
Zfish   565 FIGKQYIHCMLQDKTNGF--FLLRFSDSEIGGITIAYVEPTENGGRRVQNIQPFTKKDLDSAGLG 627

  Fly   663 DRIRDLDVLCWLHPSDRNASPVKRDVAFGEFYSKRQEPEPLVLDPVTGYVKSTLHVHVCRNGENG 727
            |||||:..:..::|.      :.::.||.::::....|.      ..||:...| ..|...|:|
Zfish   628 DRIRDISCISHVYPG------IPKNEAFKKYFTVPSAPN------ADGYLPFKL-TTVVNPGDN- 678

  Fly   728 STSGTPHHAQESMQLGNISPQSGITF 753
            ||| |.:...|::.:..|||.:...|
Zfish   679 STS-TNNITSENISMNFISPSTSQAF 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stat92E	NP_001262760.1	STAT_int	2..119	CDD:214942	30/136 (22%)
		STAT_alpha	151..340	CDD:279369	48/207 (23%)
		STAT_bind	342..587	CDD:280939	103/254 (41%)
		SH2_STAT_family	578..696	CDD:198175	46/121 (38%)
stat6	NP_001124062.1	STAT_int	2..122	CDD:214942	30/151 (20%)
		STAT_alpha	147..300	CDD:279369	43/180 (24%)
		STAT_bind	302..550	CDD:280939	103/254 (41%)
		SH2_STAT6	541..669	CDD:198240	49/141 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579986
Domainoid	1	1.000	108	1.000	Domainoid score	I6368
eggNOG	1	0.900	-	-		E1_KOG3667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	338	1.000	Inparanoid score	I2347
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D166575at33208
OrthoFinder	1	1.000	-	-		FOG0001643
OrthoInspector	1	1.000	-	-		otm25035
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11801
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1200
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.860