DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stat92E and stat1a

DIOPT Version :9

Sequence 1:	NP_001262760.1	Gene:	Stat92E / 42428	FlyBaseID:	FBgn0016917	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_571555.1	Gene:	stat1a / 30768	ZFINID:	ZDB-GENE-980526-499	Length:	749	Species:	Danio rerio

Alignment Length:	826	Identity:	204/826 - (24%)
Similarity:	346/826 - (41%)	Gaps:	174/826 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 YEEKGMLELRLCLAPWIED-------RIMSEQITP----NTTDQLERVALKF--NEDL--QQKLL 70
            |::...:.:|..|:.|||.       .:.:|.:..    :...||:....:|  .:|.  |..:.
Zfish    22 YDDNFPMAIRQYLSSWIESHDWDHVANVENESLATVRFHDLLTQLDHQHSRFVMEKDFLNQHNIR 86

  Fly    71 STRTASDQALKFRVVELCALIQRISAVELYTHLRSGLQKELQLVTEKSVAATAGQSMPLNPYNMN 135
            ..:.......:...|.:..:|.|        :||.          |:.:.|.||.|       .:
Zfish    87 KFKRNLQNLFQDNPVSMAMIISR--------NLRE----------ERKIIAIAGMS-------ES 126

  Fly   136 NTPMVTGYMVDPSDLLAVSNSCNPPVVQGIGPIHNVQNTGIASPALGMVTPKVELYEVQHQIMQS 200
            .||..|      .|::...|......|:.|.  :.||:   |...:..:....:.|:.:::..||
Zfish   127 PTPNPT------QDMIVEKNREMDARVKDIK--NKVQD---AEQTIKNLEDLQDEYDFKNKTYQS 180

  Fly   201 LNEFGNCANALKLLAQNYSYMLNSTSSP---NAE-----AAYRSLIDEKAAIVLTMRRSFMYYES 257
            .:|                  ||.|.|.   |.|     |.:..|.|::...:..|.......|.
Zfish   181 RDE------------------LNGTISKEDLNREKLMIHAMFVKLNDKRIMAISQMSEVLNLVEP 227

  Fly   258 -LHEMVIHELKNWRHQQAQAGNGAPFNEGSLDDIQRCFEMLESFIAHMLAAVKELMRVRLVTEEP 321
             :.|::..||..|:.:|..|..|...|. .||.:|..|..|...:......:|:|:.:     |.
Zfish   228 VICELISTELVEWKRRQQMACIGGLTNV-CLDQLQNWFTSLGESLLQSRQQLKKLLEL-----EQ 286

  Fly   322 ELTH-----------LLEQVQNAQKNLVCSAFIVDKQP--------PQVMKTNTRFAASVRWLIG 367
            :|::           |.|::.:..||||.::.:|::||        |.|:||...|...:|.|:
Zfish   287 KLSYSTDPITCSKISLEERIMSNLKNLVTNSLVVERQPCMPTQLQRPLVLKTGVLFTLKLRLLV- 350

  Fly   368 SQLGIHNNPPTVECIIMSEIQSQRFVTRNTQMDNSSLSGQSSGEIQNASSTMEYQQNNHVFSASF 432
             ::...|:...|:.....:|..:|   :..:|.|  :.|.|       ...|..:::|.: :|.|
Zfish   351 -KIPEFNHTVRVKVQFDKDIVEKR---KGFRMFN--ILGTS-------MKVMNMEESNGM-AAEF 401

  Fly   433 RNMQLKKIKRAEKKGTES---VMDEKFALFFYTTTTVNDFQIRVWTLSLPVVVIVHGNQEPQSWA 494
            |::|||:.|....:.:|.   |.:|..::.|......:...|...|.|||:|||.:.:|.|..||
Zfish   402 RHLQLKERKVTGNRTSEGPLIVTEELHSITFEAELCWSGLVINFETTSLPIVVISNVSQLPSGWA 466

  Fly   495 TITWDNAFAEIVRDP-----FMITDRVTWAQLSVALNIKFGSCTGRSLTIDNLDFLYEKL----Q 550
            :|.|.|.   ::.:|     |:.....||.||...|:.:|.|.|.|.|..:.|..|..||    .
Zfish   467 SIMWYNM---LISEPKNLSFFVTPPPATWGQLQEVLSWQFSSITKRGLNPEQLSMLGNKLLGPKA 528

  Fly   551 REERSEYITWNQFCKEPMPDRSFTFWEWFFAIMKLTKDHMLGMWKAGCIMGFINKTKAQTDLLRS 615
            ..:....|.||:|||.. .:::||||.|..|::.|.|.|:|.:|..||||||:  ||.:|..|.:
Zfish   529 ASDPEAQIPWNRFCKSG-SEKNFTFWLWIEAVLDLIKRHLLSLWDDGCIMGFV--TKDRTKSLLN 590

  Fly   616 VYGIGTFLLRFSDSEL-GGVTIAYV----NENGLVTMLAPWTARDFQVLNLADRIRDLDVLC--- 672
            ....||||||||:|.. |.:|.::|    ||:..:..:.|:|.::...::|.|.||:..|:.
Zfish   591 NKAPGTFLLRFSESNRDGAITFSWVEHDANEDPQIRSVEPYTKKELSAVSLPDIIRNYRVMAADN 655

  Fly   673 -------WLHPSDRNASPVKRDVAFGEFYSK---RQEPEPLVLDPVTGYVKSTLHVHVCRNGENG 727
                   :|:|.      :.:|.||.::|:|   :|||..:......||:.:||
Zfish   656 VPENPLRFLYPQ------IPKDDAFKKYYTKPTDKQEPMDVDKKADEGYISTTL----------- 703

  Fly   728 STSGTPHHAQESMQLGNISPQSGITFYSPARLEESDSDASETAEAL 773
             .|.:....||..:  |:.|.|...:....|:...|:...|.|:.:
Zfish   704 -ISISEMKPQEYNE--NLMPMSPEVYGELERMNRFDTVQLEPADLM 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stat92E	NP_001262760.1	STAT_int	2..119	CDD:214942	18/112 (16%)
		STAT_alpha	151..340	CDD:279369	44/208 (21%)
		STAT_bind	342..587	CDD:280939	75/264 (28%)
		SH2_STAT_family	578..696	CDD:198175	44/132 (33%)
stat1a	NP_571555.1	STAT_int	2..123	CDD:214942	20/118 (17%)
		STAT_alpha	140..316	CDD:279369	44/204 (22%)
		STAT_bind	318..564	CDD:280939	75/264 (28%)
		SH2_STAT1	555..704	CDD:198235	52/168 (31%)
		STAT1_TAZ2bind	712..734	CDD:288974	6/23 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D166575at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11801
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920