DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stat92E and stat3

DIOPT Version :9

Sequence 1:	NP_001262760.1	Gene:	Stat92E / 42428	FlyBaseID:	FBgn0016917	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	XP_005163850.2	Gene:	stat3 / 30767	ZFINID:	ZDB-GENE-980526-68	Length:	821	Species:	Danio rerio

Alignment Length:	942	Identity:	223/942 - (23%)
Similarity:	367/942 - (38%)	Gaps:	265/942 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLWKRISSHVDCEQRMAAY-------YEEKGMLELRLCLAPWIEDR-------------IMSEQ 45
            |:.|.::      :|....|       |.:...:|||..||||||.:             ::...
Zfish    16 MAQWNQL------QQLETRYLEQLYHLYSDSFPMELRQFLAPWIESQDWAYAANKESHATLVFHN 74

  Fly    46 ITPNTTDQLERVALKFNEDLQQKLLSTRTASDQALKFRVVELCALIQRISAVELYTHLRSGLQKE 110
            :......|..|...:.|...|..|...:    |.|:.:.:|....|.||.|..|:..     |:.
Zfish    75 LLGEIDQQYSRFLQENNVLYQHNLRRIK----QHLQSKYLEKPMEIARIVARCLWEE-----QRL 130

  Fly   111 LQLVTEKSVAATAGQSMPLNPYNMNNTPMVTGYMVDPSDLLAVSNSCNPPVVQGIGPIHNVQNTG 175
            ||      .|.||.|.               |.:..|:..:.....   .:::     ||:|:
Zfish   131 LQ------TATTAQQD---------------GQVAHPTGTVVTEKQ---QILE-----HNLQD-- 164

  Fly   176 IASPALGMVTPKVELYEVQHQIMQSL-NEFGNCANALKLLAQNYSYMLNSTSSPNA--------- 230
                    :..:|:..|.:.:::::| ::|......|| .|...|..||..|...|
Zfish   165 --------IRKRVQDMEQKMKMLENLQDDFDFNYKTLK-SAGELSQDLNGNSQAAATRQKMSQLE 220

  Fly   231 ------EAAYRSLIDEKAAIVLTMRRSFMYYESLHEMVIHELKNWRHQQAQAGNGAPFNEGSLDD 289
                  :...|.::.|.|.::..|  .|:......|    ||.:|:.:|..|..|.|.|
Zfish   221 QMLSALDQLRRQIVTEMAGLLSAM--DFVQKNLTDE----ELADWKRRQQIACIGGPPN------ 273

  Fly   290 IQRCFEMLESFIAHMLAAVKEL-MRVRLVTE---------EPELTH---LLEQVQNAQKNLVCSA 341
              .|.:.||::|..:..:..:: .::|.:.|         :|.:.|   |.|::.:..:||:.||
Zfish   274 --ICLDRLETWITSLAESQLQIRQQIRKLEELQQKVSYKGDPIIQHRPALEEKIVDLFRNLMKSA 336

  Fly   342 FIVDKQP--------PQVMKTNTRFAASVRWLIGSQLGIHNNPPTVECIIMSEIQSQRFVTRNTQ 398
            |:|::||        |.|:||..:|...||.|:                        :|...|.|
Zfish   337 FVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLV------------------------KFPELNYQ 377

  Fly   399 MDNSSLSGQSSGEIQNASSTMEY-------------QQNNHVFSASFRNMQLKKIK-----RAEK 445
            :.......:.||::.....:.::             :.||...||.|:::.|::.:     |...
Zfish   378 LKIKVCIDKESGDVAAIRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRTNS 442

  Fly   446 KGTESVMDEKFALFFYTTTTVNDFQIRVWTLSLPVVVIVHGNQEPQSWATITWDNAFAEIVRDPF 510
            ..:..|.:|...:.|.|.......:|.:.|.|||||||.:..|.|.:||:|.|.|......::..
Zfish   443 DASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNHPKNVN 507

  Fly   511 MITDRV--TWAQLSVALNIKFGSCTGRSLTIDNLDFLYEKL----------QREERSEYITWNQF 563
            ..|...  ||.|::..|:.:|.|.|.|.|||:.|..|.|||          |       |||.:|
Zfish   508 FFTKPPVGTWDQVAEVLSWQFSSTTKRGLTIEQLTTLAEKLLGPCVNYSGCQ-------ITWAKF 565

  Fly   564 CKEPMPDRSFTFWEWFFAIMKLTKDHMLGMWKAGCIMGFINKTKAQTDLLRSVYGIGTFLLRFSD 628
            |||.|..:.|:||.|...|:.|.|.::|.:|..|.|||||:|.:.:..|  |....||||||||:
Zfish   566 CKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAIL--SPKPPGTFLLRFSE 628

  Fly   629 -SELGGVTIAYVNE--NG--LVTMLAPWTARDFQVLNLAD-----RIRD-----LDVLCWLHPSD 678
             |:.||:|..:|.:  ||  .:..:.|:|.:....::.|:     :|.|     :..|.:|:|.
Zfish   629 SSKEGGITFTWVEKDINGKTQIQSVEPYTKQQLNSMSFAEIIMGYKIMDATNILVSPLVYLYPD- 692

  Fly   679 RNASPVKRDVAFGEFYSKRQEPEPLVLDPVTG-----YVKSTLHVHVC----------------- 721
                 :.::.|||::.  |.|..|....|.||     |:|:..   :|
Zfish   693 -----IPKEEAFGKYC--RPEAHPDTEFPDTGCVTQPYLKTKF---ICVTPCPSVFMDFPDSELL 747

  Fly   722 RNGENGSTSGTPHHAQESMQLGNISPQSGITFYSPARLEESDSDASETAEA----LERIVIGAQP 782
            .||..|:.||         ...::.|.|..|..|...        :|.|||    ||.:.:..:.
Zfish   748 GNGFPGTNSG---------NTSDLFPMSPRTLDSLMH--------NEAAEANPGPLESLTLDMEL 795

  Fly   783 NDPVISEITDALLTSNYRHGDFGMADFDTITN 814
            :....|.:.:....|.       ::|.||..|
Zfish   796 SSDHASPMREGFAAST-------VSDMDTCRN 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stat92E	NP_001262760.1	STAT_int	2..119	CDD:214942	29/136 (21%)
		STAT_alpha	151..340	CDD:279369	41/217 (19%)
		STAT_bind	342..587	CDD:280939	76/282 (27%)
		SH2_STAT_family	578..696	CDD:198175	41/132 (31%)
stat3	XP_005163850.2	STAT_int	17..134	CDD:214942	29/137 (21%)
		STAT_alpha	155..335	CDD:279369	41/212 (19%)
		STAT_bind	337..589	CDD:280939	76/282 (27%)
		SH2_STAT3	570..733	CDD:198237	54/175 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D166575at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11801
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920