DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stat92E and Stat3

DIOPT Version :9

Sequence 1:	NP_001262760.1	Gene:	Stat92E / 42428	FlyBaseID:	FBgn0016917	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_036879.1	Gene:	Stat3 / 25125	RGDID:	3772	Length:	770	Species:	Rattus norvegicus

Alignment Length:	857	Identity:	208/857 - (24%)
Similarity:	342/857 - (39%)	Gaps:	205/857 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLWKRISSHVDCE--QRMAAYYEEKGMLELRLCLAPWIEDR-------------IMSEQITPNT 50
            |:.|.:: ..:|..  :::...|.:...:|||..||||||.:             ::...:....
  Rat     1 MAQWNQL-QQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNLLGEI 64

  Fly    51 TDQLERVALKFNEDLQQKLLSTRTASDQALKFRVVELCALIQRISAVELYTHLRSGLQKELQLVT 115
            ..|..|...:.|...|..|...:    |.|:.|.:|....|.||.|..|:...|       .|.|
  Rat    65 DQQYSRFLQESNVLYQHNLRRIK----QFLQSRYLEKPMEIARIVARCLWEESR-------LLQT 118

  Fly   116 EKSVAATAGQ-SMPLNPYNMNNTPMVTGYMVD----PSDLLAVSNSCNPPVVQGIGPIHNVQNTG 175
            ..:.|...|| :.|..........|:..::.|    ..||           .|.:..:.|:|:.
  Rat   119 AATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDL-----------EQKMKVVENLQDD- 171

  Fly   176 IASPALGMVTPKVELYEVQHQI------MQSLNEFGNCANALKLLAQNYSYMLNSTSSPNAEAAY 234
                           ::..::.      ||.||  ||..:..:...|....||.:     .:...
  Rat   172 ---------------FDFNYKTLKSQGDMQDLN--GNNQSVTRQKMQQLEQMLTA-----LDQMR 214

  Fly   235 RSLIDEKAAIVLTMRRSFMYYESLHEMVIHELKNWRHQQAQAGNGAPFNEGSLDDIQRCFEMLES 299
            ||::.|.|.::..|.    |.:.  .:...||.:|:.:|..|..|.|.|        .|.:.||:
  Rat   215 RSIVSELAGLLSAME----YVQK--TLTDEELADWKRRQQIACIGGPPN--------ICLDRLEN 265

  Fly   300 FIAHM----------LAAVKELMRVRLVTEEPELTH---LLEQVQNAQKNLVCSAFIVDKQP--- 348
            :|..:          :..::||.:......:|.:.|   |.|::.:..:||:.|||:|::||
  Rat   266 WITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVDLFRNLMKSAFVVERQPCMP 330

  Fly   349 -----PQVMKTNTRFAASVRWLIGSQLGIHNNPPTVECIIMSEIQSQRFVTRNTQMDNSSLSGQS 408
                 |.|:||..:|...||.|:                        :|...|.|:.......:.
  Rat   331 MHPDRPLVIKTGVQFTTKVRLLV------------------------KFPELNYQLKIKVCIDKD 371

  Fly   409 SGEIQNASSTMEY-------------QQNNHVFSASFRNMQLKKIK-----RAEKKGTESVMDEK 455
            ||::.....:.::             :.||...||.|:::.|::.:     ||....:..|.:|.
  Rat   372 SGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEEL 436

  Fly   456 FALFFYTTTTVNDFQIRVWTLSLPVVVIVHGNQEPQSWATITWDNAFAEIVRDPFMITDRV--TW 518
            ..:.|.|.......:|.:.|.|||||||.:..|.|.:||:|.|.|......::....|...  ||
  Rat   437 HLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTW 501

  Fly   519 AQLSVALNIKFGSCTGRSLTIDNLDFLYEKL----------QREERSEYITWNQFCKEPMPDRSF 573
            .|::..|:.:|.|.|.|.|:|:.|..|.|||          |       |||.:||||.|..:.|
  Rat   502 DQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQ-------ITWAKFCKENMAGKGF 559

  Fly   574 TFWEWFFAIMKLTKDHMLGMWKAGCIMGFINKTKAQTDLLRSVYGIGTFLLRFSD-SELGGVTIA 637
            :||.|...|:.|.|.::|.:|..|.|||||:|.:.:..|  |....||||||||: |:.||||..
  Rat   560 SFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAIL--STKPPGTFLLRFSESSKEGGVTFT 622

  Fly   638 YVNEN----GLVTMLAPWTARDFQVLNLAD-----RIRD-----LDVLCWLHPSDRNASPVKRDV 688
            :|.::    ..:..:.|:|.:....::.|:     :|.|     :..|.:|:|.      :.::.
  Rat   623 WVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPD------IPKEE 681

  Fly   689 AFGEFYSKRQEPEPLVLDP--VTGYVKSTLHVHVCRNGENGSTS----GTPHHAQESMQLGN--- 744
            |||: |.:.:..|....||  ...|:|:..   :|......|.:    .:|......||.||
  Rat   682 AFGK-YCRPESQEHPEADPGSAAPYLKTKF---ICVTPTTCSNTIDLPMSPRTLDSLMQFGNNGE 742

  Fly   745 -ISPQSGITFYS 755
             ..|.:|..|.|
  Rat   743 GAEPSAGGQFES 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stat92E	NP_001262760.1	STAT_int	2..119	CDD:214942	29/131 (22%)
		STAT_alpha	151..340	CDD:279369	38/207 (18%)
		STAT_bind	342..587	CDD:280939	76/282 (27%)
		SH2_STAT_family	578..696	CDD:198175	41/132 (31%)
Stat3	NP_036879.1	STAT_int	2..120	CDD:214942	29/129 (22%)
		STAT3_CCD	139..318	CDD:341078	42/226 (19%)
		Essential for nuclear import. /evidence=ECO:0000250	150..162		4/22 (18%)
		STAT3_DBD	321..484	CDD:341085	45/186 (24%)
		SH2_STAT3	554..715	CDD:198237	51/172 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	42	1.000	Domainoid score	I12095
eggNOG	1	0.900	-	-		E1_KOG3667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D166575at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11801
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920