DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stat92E and Stat1

DIOPT Version :9

Sequence 1:	NP_001262760.1	Gene:	Stat92E / 42428	FlyBaseID:	FBgn0016917	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_116001.2	Gene:	Stat1 / 25124	RGDID:	3771	Length:	749	Species:	Rattus norvegicus

Alignment Length:	857	Identity:	212/857 - (24%)
Similarity:	354/857 - (41%)	Gaps:	196/857 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLWKRISSHVDCE--QRMAAYYEEKGMLELRLCLAPWIEDR-------------IMSEQITPNT 50
            ||.|..: ..:|.:  :::...|::...:|:|..||.|:|.:             |....:....
  Rat     1 MSQWYEL-QQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAAYDVSFATIRFHDLLSQL 64

  Fly    51 TDQLERVALKFNEDLQQKLLSTRTASDQALKFRVVELCALIQRISAVELYTHLRSGLQKELQLVT 115
            .||..|.:|:.|..||..:..::.......:...|::..:|...                  |..
  Rat    65 DDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPVQMSMIIHNC------------------LKE 111

  Fly   116 EKSVAATAGQSMPLNPYNMNNTPMVTGYMVDPSDLLAVSNSCNPPVVQGIGPIHNVQNTGIASPA 180
            |:.:...|.:.......|:.||     .|:|....|.             ..:.||
  Rat   112 ERKILENAQRFNQAQEGNIQNT-----VMLDKQKELD-------------SKVRNV--------- 149

  Fly   181 LGMVTPKVELYEVQHQIMQSLNEFGNCANALKLLAQNYSYMLNSTSSPNAEAAYRSLIDEKAAIV 245
                  |.::..::|:|           ..|:.|...|.:...::.:..:||...:..|:|...:
  Rat   150 ------KDQVMCIEHEI-----------KTLEDLQDEYDFKCKTSQNRESEANGVAKSDQKQEQL 197

  Fly   246 LTMRRSFMYYESLHEMVIH-------------------ELKNWRHQQAQAGNGAPFNEGSLDDIQ 291
            | :.:.|:..::..:.:||                   ||..|:.:|..|..|.|.| ..||.:|
  Rat   198 L-LHKMFLMLDNKRKEIIHKIRELLNSIELTQNTLINDELVEWKRRQQSACIGGPPN-ACLDQLQ 260

  Fly   292 RCFEMLESFIAHMLAAVKELMRVRLVTEEPELTHLLEQ---VQNAQ----------KNLVCSAFI 343
            ..|.::...:..:...:|:|       ||.|.....||   .:|.|          :.|:.|:|:
  Rat   261 SWFTIVAESLQQVRQQLKKL-------EELEQKFTYEQDPITKNKQVLSDRTFVLFQQLIQSSFV 318

  Fly   344 VDKQP--------PQVMKTNTRFAASVRWLIGSQLGIHNNPPTVECIIMSEIQSQRFVTRNTQMD 400
            |::||        |.|:||..:|...:|.|:..|...:|        :..::...:.|.     :
  Rat   319 VERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYN--------LKVKVSFDKDVN-----E 370

  Fly   401 NSSLSGQSSGEIQNASS---TMEYQQNNHVFSASFRNMQLKKIKRAEKKGTES---VMDEKFALF 459
            .:::.|.....|....:   .|| :..|...:|.||::|||:.|.|..:..|.   |.:|..:|.
  Rat   371 KNTVKGFRKFNILGTHTKVMNME-ESTNGSLAAEFRHLQLKEQKNAGNRTNEGPLIVTEELHSLS 434

  Fly   460 FYTTTTVNDFQIRVWTLSLPVVVIVHGNQEPQSWATITWDNAFAEIVRDP-----FMITDRVTWA 519
            |.|........|.:.|.|||||||.:.:|.|..||:|.|.|.   :|.:|     |:......|:
  Rat   435 FETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNM---LVTEPRNLSFFLNPPCAWWS 496

  Fly   520 QLSVALNIKFGSCTGRSLTIDNLDFLYEKLQREERSE--YITWNQFCKEPMPDRSFTFWEWFFAI 582
            |||..|:.:|.|.|.|.|..|.|..|.|||.......  .|.|.:||||.:.|::|:||.|...|
  Rat   497 QLSEVLSWQFSSVTKRGLNADQLSMLGEKLLGPNAGPDGLIPWTRFCKENINDKNFSFWPWIDTI 561

  Fly   583 MKLTKDHMLGMWKAGCIMGFINKTKAQTDLLRSVYGIGTFLLRFSDSEL-GGVTIAYV--NENG- 643
            ::|.|.|:|.:|..|||||||:|.:.:. ||:.... ||||||||:|.. |.:|..:|  ::||
  Rat   562 LELIKKHLLCLWNDGCIMGFISKERERA-LLKDQQP-GTFLLRFSESSREGAITFTWVERSQNGG 624

  Fly   644 --LVTMLAPWTARDFQVLNLADRIRDLDVLC----------WLHPSDRNASPVKRDVAFGEFYSK 696
              ....:.|:|.::...:...|.||:..|:.          :|:|:      :.:|.|||::||:
  Rat   625 EPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKYLYPN------IDKDHAFGKYYSR 683

  Fly   697 RQE-PEPLVLDPV--TGYVKSTLHVHVCRNGENGSTSGTPHHAQESMQLGNISPQSGITFYSPAR 758
            .:| |||:.||..  |||:|:.|            .|.:..|........|:.|.|...|...::
  Rat   684 PKEAPEPMELDDPKRTGYIKTEL------------ISVSEVHPSRLQSTENLLPMSPEEFDEMSK 736

  Fly   759 LEESDSDASETA 770
            :..|:.|:..:|
  Rat   737 IVGSEFDSMMSA 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stat92E	NP_001262760.1	STAT_int	2..119	CDD:214942	22/131 (17%)
		STAT_alpha	151..340	CDD:279369	39/220 (18%)
		STAT_bind	342..587	CDD:280939	81/265 (31%)
		SH2_STAT_family	578..696	CDD:198175	44/133 (33%)
Stat1	NP_116001.2	STAT_int	2..121	CDD:214942	23/137 (17%)
		STAT_alpha	139..315	CDD:279369	39/223 (17%)
		STAT_bind	317..566	CDD:280939	81/265 (31%)
		SH2_STAT1	557..707	CDD:198235	56/169 (33%)
		STAT1_TAZ2bind	715..739	CDD:288974	4/23 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	42	1.000	Domainoid score	I12095
eggNOG	1	0.900	-	-		E1_KOG3667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D166575at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11801
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920