DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stat92E and Stat5a

DIOPT Version :9

Sequence 1:	NP_001262760.1	Gene:	Stat92E / 42428	FlyBaseID:	FBgn0016917	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_058760.2	Gene:	Stat5a / 24918	RGDID:	3773	Length:	793	Species:	Rattus norvegicus

Alignment Length:	855	Identity:	264/855 - (30%)
Similarity:	387/855 - (45%)	Gaps:	194/855 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 DCEQRMAAYYEEKGMLELRLCLAPWIEDRIMSEQITPNTTDQLERVALKFNEDLQQKLLSTRTAS 76
            |..::|...|.:...:|:|..||.|||.:........|..|:.:  |.:..|.|.|:|  .:.|.
  Rat    13 DALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRGQ--ATQLLEGLVQEL--QKKAE 73

  Fly    77 DQA------LKFRVVELCALIQRI---SAVELYTHLRSGLQKELQLVTEKSVAATAGQSMPLNPY 132
            .|.      ||.::......:|..   ..:||...:|..|..|.:||.|
  Rat    74 HQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLVRE---------------- 122

  Fly   133 NMNNTPMVTGYMVDPSDLLAVSNSCNPPVVQGIGPIHNVQNTGIASPALGMVTPKVELYEVQH-Q 196
                                 :|:|:.|             .|:...|:..          :| |
  Rat   123 ---------------------ANNCSSP-------------AGVLVDAMSQ----------KHLQ 143

  Fly   197 IMQSLNEF----GNCANALKLLAQNYSY-------------------MLNSTSSPNAEAA----- 233
            |.|:..|.    .:..:.||.|.|...|                   .||.....:.|.|
  Rat   144 INQTFEELRLITQDTESELKKLQQTQEYFIIQYQESLRIQAQFAQLAQLNPQERMSRETALQQKQ 208

  Fly   234 ----------------YRSLIDEKAAIVLTMRRSFMYYESLHEMVI--HELKNWRHQQAQAGNGA 280
                            ||..:.||....|.:.|.       .:.:|  .||..|:.:|..||||.
  Rat   209 VSLETWLQREAQTLQQYRVELAEKHQKTLQLLRK-------QQTIILDDELIQWKRRQQLAGNGG 266

  Fly   281 PFNEGSLDDIQRCFEMLESFI----------AHML------AAVKELMRVRLVTEEPELTHLLEQ 329
            | .|||||.:|...|.|...|          .|:.      ..|:|::        .|:...:..
  Rat   267 P-PEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEML--------AEVNATITD 322

  Fly   330 VQNAQKNLVCSAFIVDKQPPQVMKTNTRFAASVRWLIGSQLGIHNNPPTVECIIMSEIQSQRFV- 393
            :.:|   ||.|.||::||||||:||.|:|||:||.|:|.:|.:|.|||.|:..|:||.|::..:
  Rat   323 IISA---LVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLK 384

  Fly   394 TRNTQMDNSSLSGQSSGEIQNASSTMEYQQNNHVFSASFRNMQLKKIKRAEKKGTESVMDEKFAL 458
            ..||:.|       .||||.|....|||.|.....||.||||.||:||||:::|.|||.:|||.:
  Rat   385 NENTRND-------YSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRADRRGAESVTEEKFTV 442

  Fly   459 FFYTTTTV--NDFQIRVWTLSLPVVVIVHGNQEPQSWATITWDNAFAEIVRDPFMITDRVTWAQL 521
            .|.:..:|  |:...:|.||||||||||||:|:..:.||:.|||||||..|.||.:.|:|.|.||
  Rat   443 LFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATATVLWDNAFAEPGRVPFAVPDKVLWPQL 507

  Fly   522 SVALNIKFGS--CTGRSLTIDNLDFLYEKL-------QREERSEYITWNQFCKEPMPDRSFTFWE 577
            ..|||:||.:  .:.|.||.:||.||.:||       ..:..|..::|:||.:|.:|..::|||:
  Rat   508 CEALNMKFKAEVQSNRGLTKENLVFLAQKLFNSSSNHLEDYNSMSVSWSQFNRENLPGWNYTFWQ 572

  Fly   578 WFFAIMKLTKDHMLGMWKAGCIMGFINKTKAQTDLLRSVYGIGTFLLRFSDSELGGVTIA--YVN 640
            ||..:|::.|.|....|..|.|:||:||.:|. |||.:... |||||||||||:||:|||  :.:
  Rat   573 WFDGVMEVLKKHHKPHWNDGAILGFVNKQQAH-DLLINKPD-GTFLLRFSDSEIGGITIAWKFDS 635

  Fly   641 ENGLVTMLAPWTARDFQVLNLADRIRDLDVLCWLHPSDRNASPVKRDVAFGEFYSKRQEPEPLVL 705
            .:..:..|.|:|.|||.:.:||||:.||:.|.::.| ||     .:|..|.::|:      |::.
  Rat   636 PDRNLWNLKPFTTRDFSIRSLADRLGDLNYLIYVFP-DR-----PKDEVFAKYYT------PVLA 688

  Fly   706 DPVTGYVKSTLHVHVCRNGENGSTSGTPHHAQESMQLGNISPQSGITFY----SPARLEESDSDA 766
            ..|.||||..:...|.......:.:|......:......:.||:....|    .|...::.:.|.
  Rat   689 KAVDGYVKPQIKQVVPEFVNASADAGANATYMDQAPSPVVCPQAHYNMYPPNPDPVLDQDGEFDL 753

  Fly   767 SETAEALERI 776
            .||.:....:
  Rat   754 DETMDVARHV 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stat92E	NP_001262760.1	STAT_int	2..119	CDD:214942	30/115 (26%)
		STAT_alpha	151..340	CDD:279369	51/251 (20%)
		STAT_bind	342..587	CDD:280939	119/256 (46%)
		SH2_STAT_family	578..696	CDD:198175	51/119 (43%)
Stat5a	NP_058760.2	STAT_int	4..124	CDD:397135	30/151 (20%)
		STAT5_CCD	139..330	CDD:341080	46/219 (21%)
		STAT5_DBD	332..489	CDD:341087	82/163 (50%)
		SH2_STAT5a	573..712	CDD:198284	58/152 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	772..793
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340137
Domainoid	1	1.000	123	1.000	Domainoid score	I5459
eggNOG	1	0.900	-	-		E1_KOG3667
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	312	1.000	Inparanoid score	I2506
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D166575at33208
OrthoFinder	1	1.000	-	-		FOG0001643
OrthoInspector	1	1.000	-	-		otm44930
orthoMCL	1	0.900	-	-		OOG6_104819
Panther	1	1.100	-	-	O	PTHR11801
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1200
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.800