Protein Alignment Stat92E and Stat5a

DIOPT Version :10

• Sequence 1: NP_001262760.1
• Gene: Stat92E / 42428
• FlyBaseID: FBgn0016917
• Length: 818
• Species: Drosophila melanogaster
• Sequence 2: NP_058760.2
• Gene: Stat5a / 24918
• RGDID: 3773
• Length: 793
• Species: Rattus norvegicus
• Alignment Length: 855
• Identity: 264/855 - (30%)
• Similarity: 387/855 - (45%)
• Gaps: 194/855 - (22%)

  Fly    12 DCEQRMAAYYEEKGMLELRLCLAPWIEDRIMSEQITPNTTDQLERVALKFNEDLQQKLLSTRTAS 76
            |..::|...|.:...:|:|..||.|||.:........|..|:.:  |.:..|.|.|:|  .:.|.
  Rat    13 DALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRGQ--ATQLLEGLVQEL--QKKAE 73

  Fly    77 DQA------LKFRVVELCALIQRI---SAVELYTHLRSGLQKELQLVTEKSVAATAGQSMPLNPY 132
            .|.      ||.::......:|..   ..:||...:|..|..|.:||.|
  Rat    74 HQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLVRE---------------- 122

  Fly   133 NMNNTPMVTGYMVDPSDLLAVSNSCNPPVVQGIGPIHNVQNTGIASPALGMVTPKVELYEVQH-Q 196
                                 :|:|:.|             .|:...|:..          :| |
  Rat   123 ---------------------ANNCSSP-------------AGVLVDAMSQ----------KHLQ 143

  Fly   197 IMQSLNEF----GNCANALKLLAQNYSY-------------------MLNSTSSPNAEAA----- 233
            |.|:..|.    .:..:.||.|.|...|                   .||.....:.|.|
  Rat   144 INQTFEELRLITQDTESELKKLQQTQEYFIIQYQESLRIQAQFAQLAQLNPQERMSRETALQQKQ 208

  Fly   234 ----------------YRSLIDEKAAIVLTMRRSFMYYESLHEMVI--HELKNWRHQQAQAGNGA 280
                            ||..:.||....|.:.|.       .:.:|  .||..|:.:|..||||.
  Rat   209 VSLETWLQREAQTLQQYRVELAEKHQKTLQLLRK-------QQTIILDDELIQWKRRQQLAGNGG 266

  Fly   281 PFNEGSLDDIQRCFEMLESFI----------AHML------AAVKELMRVRLVTEEPELTHLLEQ 329
            | .|||||.:|...|.|...|          .|:.      ..|:|::        .|:...:..
  Rat   267 P-PEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEML--------AEVNATITD 322

  Fly   330 VQNAQKNLVCSAFIVDKQPPQVMKTNTRFAASVRWLIGSQLGIHNNPPTVECIIMSEIQSQRFV- 393
            :.:|   ||.|.||::||||||:||.|:|||:||.|:|.:|.:|.|||.|:..|:||.|::..:
  Rat   323 IISA---LVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLK 384

  Fly   394 TRNTQMDNSSLSGQSSGEIQNASSTMEYQQNNHVFSASFRNMQLKKIKRAEKKGTESVMDEKFAL 458
            ..||:.|       .||||.|....|||.|.....||.||||.||:||||:::|.|||.:|||.:
  Rat   385 NENTRND-------YSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRADRRGAESVTEEKFTV 442

  Fly   459 FFYTTTTV--NDFQIRVWTLSLPVVVIVHGNQEPQSWATITWDNAFAEIVRDPFMITDRVTWAQL 521
            .|.:..:|  |:...:|.||||||||||||:|:..:.||:.|||||||..|.||.:.|:|.|.||
  Rat   443 LFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATATVLWDNAFAEPGRVPFAVPDKVLWPQL 507

  Fly   522 SVALNIKFGS--CTGRSLTIDNLDFLYEKL-------QREERSEYITWNQFCKEPMPDRSFTFWE 577
            ..|||:||.:  .:.|.||.:||.||.:||       ..:..|..::|:||.:|.:|..::|||:
  Rat   508 CEALNMKFKAEVQSNRGLTKENLVFLAQKLFNSSSNHLEDYNSMSVSWSQFNRENLPGWNYTFWQ 572

  Fly   578 WFFAIMKLTKDHMLGMWKAGCIMGFINKTKAQTDLLRSVYGIGTFLLRFSDSELGGVTIA--YVN 640
            ||..:|::.|.|....|..|.|:||:||.:|. |||.:... |||||||||||:||:|||  :.:
  Rat   573 WFDGVMEVLKKHHKPHWNDGAILGFVNKQQAH-DLLINKPD-GTFLLRFSDSEIGGITIAWKFDS 635

  Fly   641 ENGLVTMLAPWTARDFQVLNLADRIRDLDVLCWLHPSDRNASPVKRDVAFGEFYSKRQEPEPLVL 705
            .:..:..|.|:|.|||.:.:||||:.||:.|.::.| ||     .:|..|.::|:      |::.
  Rat   636 PDRNLWNLKPFTTRDFSIRSLADRLGDLNYLIYVFP-DR-----PKDEVFAKYYT------PVLA 688

  Fly   706 DPVTGYVKSTLHVHVCRNGENGSTSGTPHHAQESMQLGNISPQSGITFY----SPARLEESDSDA 766
            ..|.||||..:...|.......:.:|......:......:.||:....|    .|...::.:.|.
  Rat   689 KAVDGYVKPQIKQVVPEFVNASADAGANATYMDQAPSPVVCPQAHYNMYPPNPDPVLDQDGEFDL 753

  Fly   767 SETAEALERI 776
            .||.:....:
  Rat   754 DETMDVARHV 763

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Stat92E	NP_001262760.1	STAT_int	2..119	CDD:214942	30/115 (26%)
		STAT_CCD	191..338	CDD:341075	44/209 (21%)
		STAT_DBD	342..502	CDD:341082	81/162 (50%)
		SH2_STAT_family	578..696	CDD:198175	51/119 (43%)
Stat5a	NP_058760.2	STAT_int	4..124	CDD:460728	30/151 (20%)
		STAT5_CCD	139..330	CDD:341080	46/219 (21%)
		STAT5_DBD	332..489	CDD:341087	82/163 (50%)
		SH2_STAT5a	573..712	CDD:198284	58/152 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	772..793